An Improved Method for the Detection of Heterozygosity of Congenital Virilizing Adrenal Hyperplasia

Lejeune-Lenain, C.; Cantraine, Francis; Dufrasnes, M.; Prévot, Françoise; Wolter, R; Franckson, Jean

doi:10.1111/j.1365-2265.1980.tb01372.x

Cited by 30 publications

(9 citation statements)

References 13 publications

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“…17-OHP and A responses at 15, 30 and 60 min after (31_24-ACTH injection were in the normal range [Lejeune-Lenain et al, 1980a] in all patients. The ratio of serum increments between 17-OHP and F was nor mal in all cases.…”

Section: P'-^-acth Stimulation Test (20 Patients)mentioning

confidence: 75%

“…The measurement of cortisol and 17-OHP during the ACTH stimulation test is useful in detecting the different forms of 21-hydroxy lase and 11 (5-hydroxylase adrenal deficien cies [Lejeune-Lenain et al, 1980a;Lobo and Goebelsmann, 1980;Rosenfield et al, 1980;Blankstein et al, 1980] in patients with nor mal basal values. The measurement of DHA-S during the same test could be useful in mild cases of 3(5-hydroxydehydrogenase defi ciency [Lobo and Goebelsmann, 1981 ].…”

Section: Discussionmentioning

confidence: 99%

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Exploration of Hirsutism: Elements for a Strategy

et al. 1983

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50 women complaining of hirsutism were investigated in order to establish an optimal strategy for hirsutism exploration. Basal hormonal evaluations were of great value, especially serum testosterone and, to a lesser degree, DHA-S and LH. LH response to LHRH stimulation appeared of little diagnostic value. ACTH stimulation tests may be useful in detecting enzyme deficiencies in patients with normal basal values. The origin of hyperandrogenism can hardly be detected by the inhibition tests. However, these tests allow to determine whether the androgen secretion is still under ACTH and/or LH control.

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Section: P'-^-acth Stimulation Test (20 Patients)mentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Exploration of Hirsutism: Elements for a Strategy

et al. 1983

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“…None of the remaining 186 women had hypothalamic ovarian insufficiency, congenital adrenal hyperplasia (CAH), hyperprolactinemia, Cushing's syndrome or androgen secreting tumors. Nineteen of the women had an elevated ACTH-index [8] during an ACTH stimulation test [9]. We performed genetic testing for 21-OH-deficiency in order to rule out late onset and heterozygous CAH in these 19 women, with 14 testing positively for heterozygosity.…”

Section: Methodsmentioning

confidence: 99%

Accurate screening for insulin resistance in PCOS women using fasting insulin concentrations

Lunger¹,

Wildt²,

Seeber³

2013

Gynecological Endocrinology

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The aims of this cross-sectional study were to evaluate the relative agreement of both static and dynamic methods of diagnosing IR in women with polycystic ovary syndrome (PCOS) and to suggest a simple screening method for IR. All participants underwent serial blood draws for hormonal profiling and lipid assessment, a 3 h, 75 g load oral glucose tolerance test (OGTT) with every 15 min measurements of glucose and insulin, and an ACTH stimulation test. The prevalence of IR ranged from 12.2% to 60.5%, depending on the IR index used. Based on largest area under the curve on receiver operating curve (ROC) analyses, the dynamic indices outperformed the static indices with glucose to insulin ratio and fasting insulin (fInsulin) demonstrating the best diagnostic properties. Applying two cut-offs representing fInsulin extremes (<7 and >13 mIU/l, respectively) gave the diagnosis in 70% of the patients with high accuracy. Currently utilized indices for assessing IR give highly variable results in women with PCOS. The most accurate indices based on dynamic testing can be time-consuming and labor-intensive. We suggest the use of fInsulin as a simple screening test, which can reduce the number of OGTTs needed to routinely assess insulin resistance in women with PCOS.

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“…In all women meeting criteria for PCOS late onset and heterozygous non-congenital adrenal hyperplasia were excluded with an ACTH stimulation test following overnight dexamethasone suppression, as previously described by Lejeune-Lenain [26]. …”

Section: Methodsmentioning

confidence: 99%

Afamin serum concentrations are associated with insulin resistance and metabolic syndrome in polycystic ovary syndrome

Seeber

Morandell

Lunger

et al. 2014

Reprod Biol Endocrinol

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BackgroundHigh plasma concentrations of the vitamin E-binding protein afamin have been previously shown to be associated with insulin resistance and metabolic syndrome. We set out to determine whether the concentration of afamin in the serum of women with polycystic ovarian syndrome (PCOS) is elevated in relation to the presence and severity of insulin resistance (IR).MethodsThis cross-sectional study looked at 53 patients with PCOS and 49 non-PCOS patients. IR was diagnosed as a HOMA Index >2.4 and confirmed with a three-hour glucose tolerance test. Serum concentrations of afamin were determined using enzyme-linked immunosorbent assay (ELISA). Clinical characteristics, hormone and metabolic parameters were correlated to afamin concentrations.ResultsSerum concentrations of afamin did not differ between women with PCOS and controls. When separated according to the presence of IR a significant difference in median afamin levels was seen between PCOS with IR and PCOS without IR (73.06+/-27.36 mg/L and 64.25+/-17.41 mg/L, p = 0.033). No difference in afamin levels was detected when comparing the few controls with IR and the controls without IR (76.20+/-27.96 mg/L and 60.44+/-21.03 mg/L, p = 0.235). On univariate analyses, afamin serum concentrations significantly correlated with BMI, triglycerides, HOMA Index, and AUC–Insulin. On multivariate linear regression analysis, only triglyceride concentration was seen to be an independent predictor of afamin. Subjects with metabolic syndrome had higher median afamin concentrations than did those without metabolic syndrome (77.43+/-28.60 mg/L and 65.08+/-18.03 mg/L, p = 0.010).ConclusionsElevated afamin concentrations are associated with the presence of metabolic syndrome in young women and may potentially serve as an independent predictor for the development of metabolic syndrome in at-risk women, especially those with IR.

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An Improved Method for the Detection of Heterozygosity of Congenital Virilizing Adrenal Hyperplasia

Cited by 30 publications

References 13 publications

Exploration of Hirsutism: Elements for a Strategy

Exploration of Hirsutism: Elements for a Strategy

Accurate screening for insulin resistance in PCOS women using fasting insulin concentrations

Afamin serum concentrations are associated with insulin resistance and metabolic syndrome in polycystic ovary syndrome

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