An improved method of wound management for pediatric patients

Lobe, Thorn E; Anderson, Glen F.; King, Denis R.; Boles, E. Thomas

doi:10.1016/s0022-3468(80)80299-5

Cited by 23 publications

(4 citation statements)

References 2 publications

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“…Clinical studies have shown that in addition to reducing healing times, use of moisture-retaining dressings also decreases patient pain, while protecting the wound from infection. [46][47][48] Furthermore, since with this treatment method no dressing changes are required, the patients may be spared the pain associated with repeated dressing changes. The physical properties of OCA are mostly desirable ones.…”

Section: Discussionmentioning

confidence: 99%

Octylcyanoacrylate for the Treatment of Partial‐thickness Burns in Swine: A Randomized, Controlled Experiment

Singer

Berrutti

Thode

et al. 1999

Academic Emergency Medicine

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Abstract. Objective: To compare re-epithelialization rates of superficial partial-thickness burns treated with octylcyanoacrylate (OCA), silver sulfadiazine (SSD), and dry gauze (controls) in swine. Methods: This was a prospective, longitudinal, blinded, controlled, experimental trial using anesthetized swine. Sixty-three standardized burns were created by applying an aluminum bar preheated to 80 o C for 20 seconds to the flanks of four young pigs. Three equal sets of 21 burns were randomly treated with OCA spray, SSD, or dry gauze (controls). Full-thickness biopsies were taken after 30 minutes and at seven and 14 days for blinded histopathologic evaluation by two dermatopathologists using hematoxylin and eosin staining. The percent of wound re-epithelialization was measured at days 7 and 14, calculated by dividing the length of the regenerated epidermis by the measured width of the biopsy. Analysis of variance (ANOVA) and repeated-measures ANOVA controlling for the individual pig were used for comparisons among groups. This study had 80% power to demonstrate a large between-group difference in percent re-epithelization (alpha = 0.05). Results: There were 63 burns and 126 biopsies. Ten biopsies were excluded for technical reasons. At seven days, there was a significant between-group difference in percent re-epithelialization. Percent re-epithelialization was greatest in the OCA group (65.0%), followed by the SSD group (37.6%), and lowest in the control group (8.8%). At 14 days, all wounds demonstrated near complete re-epithelialization and there was no significant difference in the percent of re-epithelialization among the groups. There was only one wound infection in the OCA group. Conclusions: Under these study conditions, treatment of partial-thickness burns with OCA spray resulted in a higher percent of re-epithelialization at seven but not 14 days when compared with both SSD and control, with no significant increase in infection rates. Future studies should evaluate the use of OCA for the treatment of burns in humans.

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Section: Discussionmentioning

confidence: 99%

Octylcyanoacrylate for the Treatment of Partial‐thickness Burns in Swine: A Randomized, Controlled Experiment

Singer

Berrutti

Thode

et al. 1999

Academic Emergency Medicine

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“…In a double blind study of five patients comparing the efficacy of common adhesive bandages (nonocclusive dressing) to a polyurethane dressing for the treatment of experimentally induced suction blister wounds, the polyurethane dressing–treated wounds had a superior rate of reepithelialization 35 . At least 7 additional studies confirm these results 24,36–41 . Occlusive dressings, including films, have also been shown to speed the healing of full‐thickness wounds in both man and pig 42–44 …”

Section: Dressingsmentioning

confidence: 98%

The Pig as a Model for Human Wound Healing

Sullivan

Eaglstein

Davis

et al. 2001

Wound Repair Regeneration

905

727

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The medical literature describes numerous in vitro and in vivo wound-healing models. The selection of an animal model depends on a number of factors including availability, cost, ease of handling, investigator familiarity, and anatomical/functional similarity to humans. Small mammals are frequently used for wound healing studies, however, these mammals differ from humans in a number of anatomical and physiological ways. Anatomically and physiologically, pig skin is more similar to human skin. The many similarities between man and pig would lead one to believe that the pig should make an excellent animal model for human wound healing. The purpose of this paper is to review the existing literature for evidence of this supposition and determine how well the various models correlate to human wound healing. Studies of wound dressings, topical antimicrobials, and growth factors are examined. Over 180 articles were utilized for this comparative review. Our conclusion is that the porcine model is an excellent tool for the evaluation of therapeutic agents destined for use in human wounds.

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“…10 Popular alternatives to the topical antimicrobial agents for the treatment of partial-thickness burns are the synthetic occlusive dressings. Potential advantages of occlusive dressings include the ability to reduce wound healing time, 11,12 reduction in the amount of pain experienced by patients with burns, 11,13 improved cosmetic outcome, ease of care, and low cost. A recent study demonstrated the ability of a new tissue adhesive (octylcyanoacrylate; OCA) to enhance reepithelialization of noncontaminated partial-thickness burns in swine.…”

mentioning

confidence: 99%

Octylcyanoacrylate for the Treatment of Contaminated Partial‐thickness Burns in Swine A Randomized Controlled Experiment

Singer

Mohammad

Tortora

et al. 2000

Academic Emergency Medicine

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Abstract. Objective:To compare infection and reepithelialization rates of contaminated second-degree burns treated with octylcyanoacrylate (OCA), silver sulfadiazine (SSD), polyurethane (PU) film, and dry gauze (control; C) in swine. Methods: Eighty standardized burns were created by applying an aluminum bar preheated to 80ЊC to the backs and flanks of young pigs for 20 seconds. All burns were immediately contaminated with 0

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An improved method of wound management for pediatric patients

Cited by 23 publications

References 2 publications

Octylcyanoacrylate for the Treatment of Partial‐thickness Burns in Swine: A Randomized, Controlled Experiment

Octylcyanoacrylate for the Treatment of Partial‐thickness Burns in Swine: A Randomized, Controlled Experiment

The Pig as a Model for Human Wound Healing

Octylcyanoacrylate for the Treatment of Contaminated Partial‐thickness Burns in Swine A Randomized Controlled Experiment

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