An improved multiphysics modelling approach for dielectrophoresis-based cell separation

Abstract

This article presents a new multiphysics modelling approach for cell manipulation by dielectrophoresis. This approach is proposed to model and predict the behavior of particles injected into a microchannel due to the application of an electrical field. The objective of this model is to better characterize microelectronic circuits dedicated to design and implement hybrid systems such as lab-on-chips integrating microelectronics and microfluidic structures. The proposed model allows to determine the required configuration of microelectronic circuits and needed control signals to generate. This model applies primarily to applications using dielectrophoresis cell separation in a microchannel. Then, by using the proposed model, the cell behaviour can be predicted using an advanced multiphysics simulation methode.