An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings

Alves, Pedro Nascimento; Foulon, Chris; Karolis, Vyacheslav; Bzdok, Danilo; Margulies, Daniel S.; Volle, Emmanuelle

doi:10.1038/s42003-019-0611-3

Cited by 291 publications

(271 citation statements)

References 169 publications

(185 reference statements)

Supporting

Mentioning

242

Contrasting

Unclassified

Order By: Relevance

“…Our evaluations furthermore suggested that predictive performance increased when including both baseline and trajectory data, and when complementing cortical manifold features with subcortical connectivity estimates. These findings reemphasize benefits of incorporating subcortical nodes in the characterization of large-scale cortical network organization and overall cognitive function 108,109 .…”

Section: Iqmentioning

confidence: 78%

An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization

Park

Bethlehem

Paquola

et al. 2020

Preprint

View full text Add to dashboard Cite

Adolescence is a critical time for the continued maturation of brain networks, and the current work assessed longitudinal reconfigurations of diffusion MRI derived connectomes in a large sample (n = 208). We identified an expansion of structural network representations in lower dimensional manifold spaces, with strongest effects in transmodal cortices and indicative of an increasing differentiation of these networks from the rest of the brain. Findings were shown to relate to mainly an increase in within-module connectivity and increased segregation during adolescence. Connectome findings were consistent when additionally controlling for regional changes in MRI measures of cortical morphology and myelin, despite reductions in effect sizes. On the other hand, cortical areas showing manifold expansion were found to become more closely embedded with subcortical targets, notably the striatum. Identified networks were also found to harbor genes significantly expressed in both cortical and subcortical regions. Using supervised machine learning with cross-validation, we demonstrated that cortico-subcortical manifold features at baseline and their maturational change predicted measures of intelligence at follow-up. Our findings chart adolescent connectome development and suggest that brain-wide network reconfigurations offer intermediary phenotypes between genetic-microstructural processes and cognitive-behavioral outcomes.We explored how whole-brain structural networks reconfigure during adolescence, using a novel analysis that simultaneously interrogates network and regional features. Our approach revealed an increasing differentiation of the connectome during this critical period, particularly in higher-order prefrontal and parietal regions. We could show that while this effect was only partially related to developmental trajectories of intracortical microstructure and morphology, but rather to changes in connectivity to subcortical areas, particularly the striatum. Cortico-subcortical network effects were also supported by transcriptomics and phenotype prediction, which suggested that cognitive function in adulthood was most effectively predicted when combining cortical and subcortical features. Our findings shed new light on adolescence and support a key role of cortico-subcortical integration in shaping macroscale structural networks. Park et al. | Structural connectome maturation during adolescence 3 3

show abstract

Section: Iqmentioning

confidence: 78%

An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization

Park

Bethlehem

Paquola

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…While sensory-motor cortices are primary cortices (i.e. idiotypic areas Mesulam, 1998) and the default-mode network has been associated with transmodal higher-order functions (Margulies et al, 2016, Alves et al 2019. The principal gradient may thus represent one fundamental principle driving a hierarchical organisation of cognitive functions (Huntenburg, Bazin, & Margulies, 2018).…”

Section: Introductionmentioning

confidence: 99%

Mapping the principal gradient onto the corpus callosum

Friedrich

Forkel

Schotten

2020

Preprint

Self Cite

View full text Add to dashboard Cite

AbstractGradients capture some of the variance of the resting-state functional magnetic resonance imaging (rsfMRI) signal. Amongst these, the principal gradient depicts a functional processing hierarchy that spans from sensory-motor cortices to regions of the default-mode network. While the cortex has been well characterised in terms of gradients little is known about its underlying white matter. For instance, comprehensive mapping of the principal gradient on the largest white matter tract, the corpus callosum, is still missing. We hence mapped the principal gradient onto the callosal midsection using the 7T human connectome project dataset. We further explored how quantitative measures and variability in callosal midsection connectivity relate to the principal gradient values. In so doing, we demonstrated that the extreme values of the principal gradient are located within the callosal genu and the posterior body, have lower connectivity variability but a larger spatial extent along the midsection of the corpus callosum than mid-range values. Our results shed light on the relationship between the brain’s functional hierarchy and the corpus callosum. We further speculate about how these results may bridge the gap between functional hierarchy, brain asymmetries, and evolution.

show abstract

“…The hypothalamus is not included in the functional connectivity gradient, although it also belongs to the olfactocentric system. As one limitation of surface analyses is that they notoriously underestimate deep subcortical structures, this may might explain this discrepancy (Alves et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…The other system arises from the hippocampus and progressively radiates medially along the cingulate cortex to reach the dorsolateral frontal cortex and superior parietal lobule, this system is referred to as hippocampocentric (for a comprehensive review on the dual origin see Pandya et al, 2017). Introducing functional gradients into this framework, the principal gradient seems to be represented by the hippocampocentric system (for anatomical reviews see Alves et al, 2019;Catani et al, 2013). This system is crucial for limbic and transmodal cognitive functions (e.g.…”

mentioning

confidence: 99%

Anchoring the human olfactory system to a functional gradient

Waymel

Friedrich

Bastian

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

ABSTRACTMargulies et al. (2016) demonstrated the existence of at least five independent functional connectivity gradients in the human brain. However, it is unclear how these functional gradients might link to anatomy. The dual origin theory proposes that differences in cortical cytoarchitecture originate from two trends of progressive differentiation between the different layers of the cortex, referred to as the hippocampocentric and olfactocentric systems. When conceptualising the functional connectivity gradients within the evolutionary framework of the Dual Origin theory, the first gradient likely represents the hippocampocentric system anatomically. Here we expand on this concept and demonstrate that the fifth gradient likely links to the olfactocentric system. We describe the anatomy of the latter as well as the evidence to support this hypothesis. Together, the first and fifth gradients might help to model the Dual Origin theory of the human brain and inform brain models and pathologies.

show abstract

An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings

Cited by 291 publications

References 169 publications

An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization

An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization

Mapping the principal gradient onto the corpus callosum

Anchoring the human olfactory system to a functional gradient

Contact Info

Product

Resources

About