The current work focuses on the design and implementation of an indoor surveillance application for long-term automated analysis of human activity, in a video-assisted biomedical monitoring system. Video processing is necessary to overcome noise-related problems, caused by suboptimal video capturing conditions, due to poor lighting or even complete darkness during overnight recordings. Modified wavelet-domain spatiotemporal Wiener filtering and motion-detection algorithms are employed to facilitate video enhancement, motion-activity-based indexing and summarization. Structural aspects for validation of the motion detection results are also used. The proposed system has been already deployed in monitoring of long-term abdominal sounds, for surveillance automation, motion-artefacts detection and connection with other psychophysiological parameters. However, it can be used to any video-assisted biomedical monitoring or other surveillance application with similar demands.