An improved process for the preparation of pimavanserin tartrate

Wu, Caijiao; Zhou, Qifan; Song, Dake; Li, Hui; Bao, Changshun; Liu, Xuelong; Bao, Xiaoyi; Chen, Guoliang

doi:10.1177/1747519819873643

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…1 When it synthesized Pimavanserin has been administered as its tartrate salt. 2 PMT is not a dopamine receptor antagonistbutis having inverse agonist on 5-HT2A [3][4][5][6][7] subtype receptor for the treatment of psychosis in Parkinson"s disease (PD) and used in the treatment of schizophrenia. It"s also having significant effect on insomnia, it"s selective serotonin 5-HT2A receptor inverse agonist, to the slow wave sleep.…”

Section: Introductionmentioning

confidence: 99%

Analytical studies on zero order and first order derivative and area under curve UV-spectrophotometric methods for estimation of pimavanserin tartrate in bulk and In-house tablet formulation

Wahab

Khan

Shirkhedkar

2020

IJPCA

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The proposed of work to establish simple, rapid, sensitive, economical and accurate UV spectrophotometric methods for the quantificationof Pimavanserin tartrate in bulk material and in-house tablet formulation. This study is designed to validate the developed methods as per ICH guidelines. Pimavanserin tartrate an atypical anti-psychotic drug also used for the treatment of Parkinson Disease. Four simple UV Spectroscopy methods developed and validated for the estimation of Pimavanserin tartrate, by using double beam spectrophotometer (UV-2450, Shimadzu, Japan). Maximum absorbance (λmax) of pimavanserin tartrate was observed at 226 nm used methanol as a solvent. The calibration curve of concentration range 5-30 μg/ml obeyed Beer lambert law. The % recovery was found to be in the range of 98-101%. Precision values observed less than 2 in the terms of % RSD that shows precise nature of developed methods. It was concluded that statistical analysis and the result amongst all four methods, AUC method is most simple, specific, accurate and precise. All four methods can be used as routine analysis of Pimavanserin tartrate in bulk and pharmaceutical formulations.

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