An Improved Properdin Titration, Based on the Elimination of an Inhibitor

Willers, J.M.N.; Pondman, K.W.; Winkler, K.C.

doi:10.1159/000478442

Cited by 4 publications

(4 citation statements)

References 8 publications

(12 reference statements)

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“…No direct proof that P is directly involved in any of these conditions has been reported, and that is not unexpected in view of its doubtful effect in the bactericidal reaction and lack of effect upon the growth rate or morphology of human cancer cells in tissue culture [51]. It is likely that the low P levels in these conditions may be partly caused by the liberation of endogenous materials, such as alpha-2globulin [44], which inactivate P [29] or interfere with its assay [63] as a result of extensive tissue damage, shock or stress. I n addition, the neutralization of P by necrotizing tissue of a rat sarcoma has been shown [21].…”

Section: Biological Activitiesmentioning

confidence: 99%

The Antibody‐Complement System and Properdin: A Review

Muschel

1961

Vox Sanguinis

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Properdin (P) was originally described by Pillemer and his colleagues in 1954 as an outgrowth of studies relating t o the inactivation of the third component of complement (C') by Zymosan (Z), an insoluble carbohydrate derived from yeast cell walls, or by a variety of polysaccharides or polysaccharide complexes of microbial and mammalian origin. P was defined by its reaction with Z, and sera were assayed for P by their ability to inactivate C'3 after the addition of Z [39, 401. In addition t o C' inactivation, P was believed to be responsible for many of the biological activities of normal mammalian serum requiring C': the killing of certain bacteria belonging mainly to gramnegative genera, the neutralization of several viruses, the killing of protozoa and the lysis of abnormal red blood cells including those of patients with paroxysmal nocturnal hemoglobinuria and of normal cells treated with tannic acid. Regarded as a new serum factor, P became implicated, chie%y by association, with resistance to infections in animals subjected to irreversible hemorrhagic shock [ll], in patients with severe burns [28] and in patients with pneumococcal pneumonia [16]. It was associated also with the inadequacy of immune mechanisms following x-irradiation [42] and in protection against neoplastic growth [SO]. Excellent summaries of the extensive investigations in these areas relating exclusively t o P have been written [15, 19, 20, 46, 60, 611 as well as comprehensive reviews on antimicrobial serum and tissue factors [48], non-specific resistance [47] and C' [37], which include discussions of P. This review will attempt an assessment of the conceptual aspects involved in the introduction of P as a serological entity, a critical evaluation of the postulated part played by P in various activities of serum and its role

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Section: Biological Activitiesmentioning

confidence: 99%

The Antibody‐Complement System and Properdin: A Review

Muschel

1961

Vox Sanguinis

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“…However, an interesting article published in one of the last numbers of your journal by Witters et al [5] offers an opportunity to report briefly on some aspects of the problem as it was made clear by our researches.…”

Section: Letters To the Editormentioning

confidence: 78%

Letters to the Editor

1959

Vox Sanguinis

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“…The history of properdin assay methods cannot be reviewed here. However, an interesting article published in one of the last numbers of your journal by Tillers et al [5] offers an opportunity to report briefly on some aspects of the problem as it was made clear by our researches.…”

mentioning

confidence: 77%

Letters to the Editor — Lettres à la Rédaction — Briefe an die Redaktion

1959

Vox Sanguinis

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An Improved Properdin Titration, Based on the Elimination of an Inhibitor

Cited by 4 publications

References 8 publications

The Antibody‐Complement System and Properdin: A Review

The Antibody‐Complement System and Properdin: A Review

Letters to the Editor

Letters to the Editor — Lettres à la Rédaction — Briefe an die Redaktion

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