2017
DOI: 10.1016/j.jpain.2017.02.427
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An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve

Abstract: The number of studies on trigeminal nerve injury using animal models remains limited. A rodent model of trigeminal neuropathic pain was first developed in the 1994, in which chronic constriction injury is induced by ligation of the infraorbital nerve (IoN-CCI). This animal model has served as a major tool to study trigeminal neuropathic pain. Unfortunately, the surgical procedure in this model is complicated and far more difficult than ligation of peripheral nerves (e.g. sciatic nerve). The aim of this study w… Show more

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Cited by 58 publications
(53 citation statements)
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“…The intensity of stimulation was gradually increased. The lowest force (in grams) required to elicit reactions such as immediate withdrawal, attacking the filament by biting or grabbling, escape behaviors, or asymmetric stroking of the face was recorded as the response threshold force [19].…”
Section: Mechanical Allodynia Testmentioning
confidence: 99%
“…The intensity of stimulation was gradually increased. The lowest force (in grams) required to elicit reactions such as immediate withdrawal, attacking the filament by biting or grabbling, escape behaviors, or asymmetric stroking of the face was recorded as the response threshold force [19].…”
Section: Mechanical Allodynia Testmentioning
confidence: 99%
“…Chronic constriction injury of IoN was made by the method described by Ding [35] with little modification (IoN was legated using catgut chromic 6.0 in place of 4.0). After anesthetizing the rats using ketamine (80 mg/kg) and xylazine (10 mg/kg), a 0.5 cm incision was made on the face at the place of distal portion of left IoN in a line connecting inner corner of the eye to third row of whiskers.…”
Section: Surgery Procedures To Induce Neuropathic Painmentioning
confidence: 99%
“…Bio-protocol 10(08): e3591. DOI:10.21769/BioProtoc.3591 5. Place the mouse into the induction chamber for initial anesthesia induction; the typical rapid breathing will begin to slow down to deeper breaths, moving from the upper chest to the lower chest.…”
Section: Surgical Induction Of the Frict-ion Modelmentioning
confidence: 99%
“…Previous successful chronic trigeminal pain models described have been induced by loose chromic gut suture tie of the infraorbital nerve (ION) in rats (CCI-ION) behind the eye (Vos et al, 1994;Kniffin et al, 2015) or on the snout in rats (dIoN-CCI) and mice (DIONI) (Ding et al, 2017;Hardt et al, 2019) ( Figure 1). Alternatively, the intraoral approach has also been used to induce the CCI-ION model in rats (Immamura et al, 1997).…”
mentioning
confidence: 99%