An improved understanding of pediatric chronic nonbacterial osteomyelitis pathophysiology informs current and future treatment
Eve Roberts,
Amandine Charras,
Gabriele Hahn
et al.
Abstract:Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disease that primarily affects children and young people. It can cause significant pain, reduced function, bone swelling, and even (vertebral body) fractures. Because of a limited understanding of its pathophysiology, the treatment of CNO remains empiric and is based on relatively small case series, expert opinion, and personal experience. Several studies have linked pathological NOD-kike receptor (NLR) family pyrin domain containing 3 (NLRP3… Show more
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