An improvement in corrosion resistance of 316L AISI coated using PCL-gelatin composite by dip-coating method

Shafiee, Behzad Mojarad; Torkaman, R.; Mahmoudi, M.; Emadi, Rahmatollah; Karamian, Ebrahim

doi:10.1016/j.porgcoat.2019.01.057

Cited by 23 publications

(7 citation statements)

References 31 publications

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“…The dip-coating technique proved an efficient approach to overcome the limitations of conventional metallic implants, such as bioinertness, osseointegration and long-term structural and functional performances. Such coatings have been studied out of the desire to improve the bioactivity (by encouraging initial adhesion of host cells onto the implant and by supporting normal cellular growth) and corrosion resistance of metallic implants [21,22]. Moreover, successful results have been reported by using polymeric films for surface modification of materials used in wound healing applications, as they enable the fabrication of specific hydrophilic/hydrophobic devices, with enhanced stability and fluid absorption, controllable permeability and tunable swelling behavior [23,24].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

et al. 2021

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To modulate the biofunctionality of implantable medical devices commonly used in clinical practice, their surface modification with bioactive polymeric coatings is an attractive and successful emerging strategy. Biodegradable coatings based on poly(lactic acid-co-glycolic acid), PLGA, represent versatile and safe candidates for surface modification of implantable biomaterials and devices, providing additional tunable ability for topical delivery of desired therapeutic agents. In the present study, Ibuprofen-loaded PLGA coatings (PLGA/IBUP) were obtained by using the dip-coating and drop-casting combined protocol. The composite materials demonstrated long-term drug release under biologically simulated dynamic conditions. Reversible swelling phenomena of polymeric coatings occurred in the first two weeks of testing, accompanied by the gradual matrix degradation and slow release of the therapeutic agent. Irreversible degradation of PLGA coatings occurred after one month, due to copolymer’s hydrolysis (evidenced by chemical and structural modifications). After 30 days of dynamic testing, the cumulative release of IBUP was ~250 µg/mL. Excellent cytocompatibility was revealed on human-derived macrophages, fibroblasts and keratinocytes. The results herein evidence the promising potential of PLGA/IBUP coatings to be used for surface modification of medical devices, such as metallic implants and wound dressings.

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Section: Introductionmentioning

confidence: 99%

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

et al. 2021

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“…The FTIR spectra are demonstrated in Figure 7. For polycaprolactone (P), the peak at 2913 cm −1 represents the CH 2 asymmetric stretching and the peak at 2850 cm −1 is the CH 2 symmetric stretching 51 . While 1726 and 1160 cm −1 stand for CO and CO stretching, correspondingly 52 .…”

Section: Resultsmentioning

confidence: 99%

“…For polycaprolactone (P), the peak at 2913 cm À1 represents the CH 2 asymmetric stretching and the peak at 2850 cm À1 is the CH 2 symmetric stretching. 51 While 1726 and 1160 cm À1 stand for C O and C O stretching, correspondingly. 52 For chitosan (C), 3400-3600 cm À1 is representative for N H and O H stretching, 2919 and 2874 cm À1 are CH 2 asymmetric stretching, 1640 cm À1 is C O stretching, 1592 cm À1 is N H bending, 1061 cm À1 is C O stretching.…”

Section: Fourier Transform Infrared Spectroscopymentioning

confidence: 99%

Fabrication of polycaprolactone scaffolds filled with cell‐compatible porous matrix for enhanced cell growth for biomedical applications

Hsu

Lin

et al. 2023

J of Applied Polymer Sci

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In this study, polycaprolactone (P) scaffolds are fabricated by 3D‐printing method, and subsequently a mixed solution of natural‐biocompatible chitosan (C), gelatin (G), and hydroxyapatite (H) is filled into the pores of P scaffolds. Freeze‐gelation method is then carried out to successfully form a cell‐compatible porous CGH matrix within P scaffold pores, obtaining a newly fabricated scaffold called CGH/P composite scaffold which has large specific surface area favorable for cell attachment and growth. The effects of slow cooling (sc) and fast cooling (fc) modes utilized in freeze process on pore structures of CGH matrix are observed via SEM. The use of fc mode creates a CGH matrix with a laminar structure which benefits nutrient permeation and cell migration. Mechanical properties tests indicate that the maximum compressive strength and Young's modulus of CGH/P‐fc scaffolds are 2–7 and 15–35 MPa, respectively. Cell compatibility tests show that on day 7, the cell numbers in the CGH/P‐fc scaffolds are about twofold of those in the P scaffolds, and the cell activities in the CGH/P‐fc scaffolds are even higher, indicating that the presence of laminar porous CGH matrix within P scaffold pores substantially enhances the migration, attachment, and growth of cells in the scaffolds. The results suggest that the fabricated CGH/P‐fc composite scaffold is highly promising for biomedical applications such as bone repair in the future.

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“…[1][2][3] Not only that the adsorbed proteins improve the biocompatibility of the implanted material, but they also play a pivotal role with regard to the tribological properties 4 and in the biocorrosion process. 5,6 Natural biopolymers have been extensively studied for such applications due to their ability to act as a protection barrier against physiological corrosion, their resemblance to the extracellular matrix, and proven improvement of cell attachment and proliferation. [6][7][8] Mucin is a glycoprotein with a complex structure which couples a long protein backbone with O-linked glycans ended by different sugar units.…”

mentioning

confidence: 99%

“…5,6 Natural biopolymers have been extensively studied for such applications due to their ability to act as a protection barrier against physiological corrosion, their resemblance to the extracellular matrix, and proven improvement of cell attachment and proliferation. [6][7][8] Mucin is a glycoprotein with a complex structure which couples a long protein backbone with O-linked glycans ended by different sugar units. 9 Its main role is to protect the wet epithelia in the human body, and in order to do so, mucin has the ability to form gels in certain conditions.…”

mentioning

confidence: 99%

Coatings based on mucin‐tannic acid assembled multilayers. Influence of pH

Olăreţ

Ghițman

Iovu

et al. 2020

Polymers for Advanced Techs

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Although widely used as implantable materials due to their mechanical properties, metal devices show several disadvantages, such as the lack of cellular binding sites, antibacterial properties, or lubricant properties. To this end, the development of engineered surfaces through protein coatings has been largely investigated. Due to their natural origin and complex structure which allows the formation of hydrogels, mucins have been proposed and investigated as effective coatings for metallic implants. The present study evaluates the ability of porcine gastric mucin (PGM) to form stable coatings on a model metal surface, using three buffers with different pH values, ranging from acid to alkaline, as dispersion media. Considering its large number of hydroxyl groups and its ability to form hydrogen bonds with the protein, tannic acid (TA) was used as cross‐linker. In addition to coatings' thickness and elasticity assessed through Quartz Crystal Microbalance with Dissipation monitoring (QCM‐D), the study also evaluates the interactions between PGM and TA at various pH values of the dispersion media through DLS. The corroborated results show that the neutral pH allows the best interactions between PGM and TA leading to the formation of a stable, less elastic coating when compared with that obtained using as dispersion media the other two investigated buffers. Moreover, the hydrophilicity and mechanical properties of the dried coatings were assessed through contact angle measurements and nanoindentation, respectively.

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An improvement in corrosion resistance of 316L AISI coated using PCL-gelatin composite by dip-coating method

Cited by 23 publications

References 31 publications

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

Fabrication of polycaprolactone scaffolds filled with cell‐compatible porous matrix for enhanced cell growth for biomedical applications

Coatings based on mucin‐tannic acid assembled multilayers. Influence of pH

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