An in-depth study of the associations between osteoarthritis- and osteoporosis-related phenotypes at different skeletal locations

Kasher, Melody; Williams, Frances; Freidin, Maxim B.; Cherny, Stacey S.; Livshits, Gregory

doi:10.1007/s00198-020-05504-y

Cited by 8 publications

(9 citation statements)

References 51 publications

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“…Simultaneous lower extremity varus malalignment and OP in postmenopausal women result in more rapid OA development [ 85 ]. Hand OA and low hand and arm bone mineral density are related and can increase the risk of wrist fracture [ 86 ]. Therefore, the combined use of RLX and GlcN clinically is likely because of the frequent comorbidity of OA and OP in postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

Raloxifene Ameliorates Glucosamine-Induced Insulin Resistance in Ovariectomized Rats

Cheng

Chang

et al. 2021

Biomedicines

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Osteoarthritis (OA) and osteoporosis (OP) are common among older women, especially postmenopausal women. Glucosamine (GlcN) is a common medication for OA, but it may induce insulin resistance and β-cell dysfunction, especially if ovarian hormones are lacking. Raloxifene (RLX) is a selective estrogen receptor modulator and also an OP drug. Previously, we found that estrogen could improve GlcN-induced insulin resistance in ovariectomized (OVX) rats. Here, we further hypothesized that RLX, similarly to estrogen, can ameliorate GlcN-induced insulin resistance in OVX rats. We used GlcN to induce insulin resistance in OVX rats as a model for evaluating the protective effects of RLX in vivo. We used a pancreatic β-cell line, MIN-6, to study the mechanisms underlying the effect of RLX in GlcN-induced β-cell dysfunction in vitro. Increases in fasting plasma glucose, insulin, and homeostasis model assessments of insulin resistance in OVX Sprague Dawley rats treated with GlcN were reversed by RLX treatment (n = 8 in each group). Skeletal muscle GLUT-4 increased, liver PEPCK decreased, pancreatic islet hypertrophy, and β-cell apoptosis in OVX rats treated with GlcN was ameliorated by RLX. The negative effects of GlcN on insulin secretion and cell viability in MIN-6 cells were related to the upregulation of reticulum (ER) stress-associated proteins (C/EBP homologous protein, phospho-extracellular signal-regulated kinase, phospho-c-JunN-terminal kinase), the expression of which was reduced by RLX. Pretreatment with estrogen receptor antagonists reversed the protective effects of RLX. GlcN can induce insulin resistance, β-cell dysfunction, and apoptosis in OVX rats and increase ER stress-related proteins in β-cells, whereas RLX can reverse these adverse effects. The effects of RLX act mainly through estrogen receptor α; therefore, RLX may be a candidate drug for postmenopausal women with OA and OP.

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Section: Discussionmentioning

confidence: 99%

Raloxifene Ameliorates Glucosamine-Induced Insulin Resistance in Ovariectomized Rats

Cheng

Chang

et al. 2021

Biomedicines

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“…Kasher et al. ( 7 ) confirmed that a higher hand OA score was significantly negatively correlated with arm and hand BMD measurements in males and females accompanied by a higher prevalence of wrist fracture, but the knee OA affection was positively associated with the elevated hip, spine, and total body BMD levels. A previous study also found the relationship between OA and OP was sexually different for the reason that femur neck and lumbar BMD and OA showed a positive tendency in women while BMD of the lumbar and pelvis in men was negatively correlated with OA ( 8 ).…”

Section: Introductionmentioning

confidence: 94%

“…A cross-sectional study which was aimed to reveal the relationship between radiographic features of OA and bone mineral density (BMD) found that hand osteophytes and sclerosis exhibited a positive relationship with the BMDs of the lumbar spine and femoral neck while the knee and hand joint space narrowing presented a negative tendency to the BMD of the lumbar spine and femoral neck (6). Kasher et al (7) confirmed that a higher hand OA score was significantly negatively correlated with arm and hand BMD measurements in males and females accompanied by a higher prevalence of wrist fracture, but the knee OA affection was positively associated with the elevated hip, spine, and total body BMD levels. A previous study also found the relationship between OA and OP was sexually different for the reason that femur neck and lumbar BMD and OA showed a positive tendency in women while BMD of the lumbar and pelvis in men was negatively correlated with OA (8).…”

Section: Introductionmentioning

confidence: 99%

Osteopontin, a bridge links osteoarthritis and osteoporosis

Bai

Li²,

Zhang³

2022

Front. Endocrinol.

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Osteoarthritis (OA) is the most prevalent joint disease characterized by degradation of articular cartilage, inflammation, and changes in periarticular and subchondral bone of joints. Osteoporosis (OP) is another systemic skeletal disease characterized by low bone mass and bone mineral density (BMD) accompanied by microarchitectural deterioration in bone tissue and increased bone fragility and fracture risk. Both OA and OP are mainly affected on the elderly people. Recent studies have shown that osteopontin (OPN) plays a vital role in bone metabolism and homeostasis. OPN involves these biological activities through participating in the proliferation, migration, differentiation, and adhesion of several bone-related cells, including chondrocytes, synoviocytes, osteoclasts, osteoblasts, and marrow mesenchymal stem cells (MSCs). OPN has been demonstrated to be closely related to the occurrence and development of many bone-related diseases, such as OA and OP. This review summarizes the role of OPN in regulating inflammation activity and bone metabolism in OA and OP. Furthermore, some drugs that targeted OPN to treat OA and OP are also summarized in the review. However, the complex mechanism of OPN in regulating OA and OP is not fully elucidated, which drives us to explore the depth effect of OPN on these two bone diseases.

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“…Several earlier studies have appraised the relationship between intervertebral disc disease and lumbar and/or multipoint BMD [ 21 , 22 , 23 , 24 ]. However, they did not focus on the association between LDH and lumbar BMD in both men and women.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have investigated lumbar vertebral BMD in patients with spinal disorders such as scoliosis [ 21 , 22 ], intervertebral disc degeneration [ 22 ] and osteoarthritis [ 23 , 24 ], and theories had been introduced to explain why the pathogenesis of LDH might be related to lumbar intervertebral disc degeneration (LDD) [ 25 , 26 , 27 , 28 ]. Although disc herniation is most commonly caused by mechanical injury and the consequent rupture of the fibrous annulus, some extent of initial degeneration is necessary to allow the pulpous nucleus to herniate through the fibrous bands of the annulus into the vertebral canal [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

The Association of Lumbar Disc Herniation with Lumbar Volumetric Bone Mineral Density in a Cross-Sectional Chinese Study

Geng

Wang

et al. 2021

Diagnostics

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Little is known about the effect of lumbar intervertebral disc herniation (LDH) on lumbar bone mineral density (BMD), and few previous studies have used quantitative computed tomography (QCT) to assess whether the staging of LDH correlates with lumbar vertebral trabecular volumetric bone mineral density (Trab.vBMD). To explore the relationship between lumbar Trab.vBMD and LDH, seven hundred and fifty-four healthy participants aged 20–60 years were enrolled in the study from an ongoing study on the degeneration of the spine and knee between June 2014 and 2017. QCT was used to measure L2–4 Trab.vBMD and lumbar spine magnetic resonance images (MRI) were performed to assess the incidence of disc herniation. After 9 exclusions, a total of 322 men and 423 women remained. The men and women were divided into younger (age 20–39 years) and older (age 40–60 years) groups and further into those without LDH, with a single LDH segment, and with ≥2 segments. Covariance analysis was used to adjust for the effects of age, BMI, waistline, and hipline on the relationship between Trab.vBMD and LDH. Forty-one younger men (25.0%) and 59 older men (37.3%) had at least one LDH segment. Amongst the women, the numbers were 46 (22.5%) and 80 (36.4%), respectively. Although there were differences in the characteristics data between men and women, the difference in Trab.vBMD between those without LDH and those with single and ≥2 segments was not statistically significant (p > 0.05). These results remained not statistically significant after further adjusting for covariates (p > 0.05). No associations between lumbar disc herniation and vertebral trabecular volumetric bone mineral density were observed in either men or women.

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An in-depth study of the associations between osteoarthritis- and osteoporosis-related phenotypes at different skeletal locations

Cited by 8 publications

References 51 publications

Raloxifene Ameliorates Glucosamine-Induced Insulin Resistance in Ovariectomized Rats

Raloxifene Ameliorates Glucosamine-Induced Insulin Resistance in Ovariectomized Rats

Osteopontin, a bridge links osteoarthritis and osteoporosis

The Association of Lumbar Disc Herniation with Lumbar Volumetric Bone Mineral Density in a Cross-Sectional Chinese Study

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