An in situ extractive fermentation strategy for enhancing prodigiosin production from Serratia marcescens BWL1001 and its application to inhibiting the growth of Microcystis aeruginosa

Liu, Weijie; Yang, Jing; Tian, Yanning; Zhou, Xuge; Wang, Shiwei; Zhu, Jingrong; Sun, Di; Cong, Lin

doi:10.1016/j.bej.2020.107836

Cited by 30 publications

(14 citation statements)

References 50 publications

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“…The high price of reagent grade prodigiosin and its derivatives restricts its application research to a certain extent, which is not conducive to the large‐scale experiment and the development of clinical experimental drugs. Therefore, in the past few decades, many researchers have focused on increasing the yield of prodigiosin, and a lot of research has been done on its development and application [24]. A number of related reviews summarized the progress made over the decades.…”

Section: Introductionmentioning

confidence: 99%

High‐level production of microbial prodigiosin: A review

Han

Xiang

et al. 2021

J Basic Microbiol

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Prodigiosin is a natural red pigment derived primarily from secondary metabolites of microorganisms, especially Serratia marcescens. It can also be chemically synthesized. Prodigiosin has been proven to have antitumor, antibacterial, antimalaria, anti‐insect, antialgae, and immunosuppressive activities, and is gaining increasing important in the global market because of its great potential application value in clinical medicine development, environmental treatment, preparation of food additives, and so on. Due to the low efficiency of prodigiosin chemical synthesis, high‐level prodigiosin of production by microorganisms are necessary for prodigiosin applications. In this paper, the production of prodigiosin by microorganism in recent decades is reviewed. The methods and strategies for increasing the yield of prodigiosin are discussed from the aspects of medium composition, additives, factors affecting production conditions, strain modification, and fermentation methods.

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Section: Introductionmentioning

confidence: 99%

High‐level production of microbial prodigiosin: A review

Han

Xiang

et al. 2021

J Basic Microbiol

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“…with 1.50% squid pen powder/1.0% chitin plus 0.6% casein 103.3–192.5 2,480–4,620 mg L −1 /24 h 25°C – 6.15 Ranges of pH/temps [ 171 ] S. marcescens TKU011 Erlenmeyer (50 mL) Saline medium suppl with 0.5–2% powder of squid pen, shrimp head, crab shell, and shrimp shell 10.2 978 mg L −1 /96 h 30/25°C – 7.0 Ranges of temps [ 172 ] S. marcescens SS-1 SMΔR* Erlenmeyer (50 mL) 10 g L −1 tryptone, 5 g L −1 yeast extract, 2–6% vegetable oils 5.25–7.90 525–790 mg L −1 /10 h 30°C – ≈9.0 [ 173 ] S. marcescens MO-1 Erlenmeyer (50 mL) 1.00% mannitol, 0.40% yeast extract, and 0.40% ram horn peptone 5.8 278 mg L −1 /48 h 28°C – 7.0 [ 174 ] S. marcescens BWL1001 Erlenmeyer (25 mL) Saline suppl. with 100 g L −1 soybean oil, 10 g L −1 peptone, 768.1 27,650 mg L −1 /36 h 28°C – 5.0 [ 175 ] S. marcescens S389 Sakaguchi flask (100 mL) Saline medium suppl with 15% ethanol 41.7 3,000 mg L −1 /72 h 28°C – 6.8 [ 176 ] S. marcescens WT Erlenmeyer (20 mL) Proline, peptone plus Kitchen wastewater 20.7 870 mg L −1 /42 h 28°C – 8.0 [ …”

Section: Environmental Factors Influencing Prodigiosin Productionmentioning

confidence: 99%

Prodigiosin: a promising biomolecule with many potential biomedical applications

et al. 2022

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Pigments are among the most fascinating molecules found in nature and used by human civilizations since the prehistoric ages. Although most of the bio-dyes reported in the literature were discovered around the eighties, the necessity to explore novel compounds for new biological applications has made them resurface as potential alternatives. Prodigiosin (PG) is an alkaloid red bio-dye produced by diverse microorganisms and composed of a linear tripyrrole chemical structure. PG emerges as a really interesting tool since it shows a wide spectrum of biological activities, such as antibacterial, antifungal, algicidal, anti-Chagas, anti-amoebic, antimalarial, anticancer, antiparasitic, antiviral, and/or immunosuppressive. However, PG vehiculation into different delivery systems has been proposed since possesses low bioavailability because of its high hydrophobic character (XLogP3-AA = 4.5). In the present review, the general aspects of the PG correlated with synthesis, production process, and biological activities are reported. Besides, some of the most relevant PG delivery systems described in the literature, as well as novel unexplored applications to potentiate its biological activity in biomedical applications, are proposed.

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“…Algicidal bacteria can secrete various algicidal compounds [7,8,[19][20][21]. To investigate the algicides secreted by E. hormaechei F2, components from the cultivation medium of the strain were extracted using nine different volume ratios of chloroform and methanol, and the algicidal efficiency of each extract were further tested.…”

Section: Separation and Identification Of Algicidesmentioning

confidence: 99%

“…Due to the high bacterial diversity and difficulty in separating algicidal substances, many algicides are still unknown, and only a few algicides have been identified, which include peptides [9,10], alkaloids [11,12], and lipids [13,14]. One common algicide is prodigiosin, a red pigment belonging to the antibiotic family, and is an efficient algicide [15,16] against Phaeocystis globosa [17], red tide phytoplankton [18], and M. aeruginosa [19][20][21]. Several extracellular enzymes have also been identified as potent algicides.…”

Section: Introductionmentioning

confidence: 99%

Identifying Algicides of Enterobacter hormaechei F2 for Control of the Harmful Alga Microcystis aeruginosa

Zhang

Yang

Xie

et al. 2022

IJERPH

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Eutrophication has become an increasingly serious environmental issue and has contributed towards an explosion in harmful algal blooms (HABs) affecting local development. HABs can cause serious threats to ecosystems and human health. A newly isolated algicidal strain, Enterobacter hormaechei F2, showed high algicidal activity against the typical HAB species Microcystis aeruginosa. Potential algicides were detected through liquid chromatograph–mass spectrometer analysis, revealing that prodigiosin is an algicide and PQS is a quorum sensing molecule. RNA-seq was used to understand the algicidal mechanisms and the related pathways. We concluded that the metabolism of prodigiosin and PQS are active at the transcriptional level. The findings indicate that E. hormaechei F2 can be used as a potential biological agent to control harmful algal blooms to prevent the deterioration of the ecological and economic value of water bodies.

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An in situ extractive fermentation strategy for enhancing prodigiosin production from Serratia marcescens BWL1001 and its application to inhibiting the growth of Microcystis aeruginosa

Cited by 30 publications

References 50 publications

High‐level production of microbial prodigiosin: A review

High‐level production of microbial prodigiosin: A review

Prodigiosin: a promising biomolecule with many potential biomedical applications

Identifying Algicides of Enterobacter hormaechei F2 for Control of the Harmful Alga Microcystis aeruginosa

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