An in Situ Procedure for The Biopsy of Pressure-Wrapped Hypertrophic Scars

Baur, P. S.; Larson, Duane L.; Sloan, David F.; Barratt, G F

doi:10.1111/1523-1747.ep12496949

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…In contrast, keloid scars exhibit large and very coarse collagen fibers arranged more haphazardly in the dermis (73). Curiously, α-smooth muscle actin positive myofibroblasts are only found in hypertrophic scars and not keloids (74).…”

Section: Histology Of Fibroproliferative Scarsmentioning

confidence: 99%

Adult and fetal wound healing

Zhao²,

Ja³

et al. 2008

Front Biosci

117

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Mammalian wound healing is an intricate process involving the coordinated interaction of a variety of tissue types and cellular lineages. This is governed by a complex array of physical, biological and chemical signals. In adult tissue, the successful completion of wound healing inevitably results in the formation of scar. However, animal studies of embryonic tissue have shown that early gestation fetal wounds heal with complete restoration of tissue structure and function. The exact mechanisms underlying scarless healing in the fetus remain to be elucidated.

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Section: Histology Of Fibroproliferative Scarsmentioning

confidence: 99%

Adult and fetal wound healing

Zhao²,

Ja³

et al. 2008

Front Biosci

117

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Ultrastructural study of tension and pressure zones in a rabbit flexor tendon

1980

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The flexor digitorum profundus tendon of the rabbit hind limb is subject to tensional forces throughout most of its length but, within a localised area which is in contact with the calcaneum and talus, it is subjected to additional compressive forces. This pressure-bearing area, in marked contrast to the tensional areas, has a fibrocartilage-like organization and a high concentration of glycosaminoglycans (GAG).Ultrastructural features of the cells, collagen and matrix in the tension and pressure zones are also markedly different, with a full spectrum of transitional characteristics in the junctional region between the two zones. These findings support the concept that the cells in the various regions are sensitive and responsive to changes in physical load.In the tensional zone, elongated cells have extensive cytoplasmic flanges, which may contact flanges of neighbouring cells, and a scalloped cell surface that intimately conforms to the adjacent positively charged and tightly packed collagen fibrils of long periodicity (63 nm) and varying diameters. In the pressure zone, round and clustered fibrocartilage-like cells, characterized by dense arrays of 11-nm-diameter microfilaments and numerous lipid droplets, are surrounded by loosely packed collagen fibrils of short periodicity (53 nm) and predominantly small diameters, and an extensive matrix rich in GAG.

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