An In Vitro Assessment of Wear Particulate Generated From NUBAC

Brown, Timothy S.; Bao, Qi Bin; Agrawal, C. Mauli; Hallab, Nadim J.

doi:10.1097/brs.0b013e31821ac8a0

Cited by 10 publications

(1 citation statement)

References 58 publications

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“…There is also concern that failure diagnosis will be delayed as clear signs do not present until failure has reached an advanced stage especially when the patient is not feeling any pain [25]. One effect of such a delay is the migration of wear debris into the blood stream of the patient leading to medical complications [20,26]. As mentioned in Section 1.1, biotribological studies have also been used to assess the condition of retrieved implants to identify the cause of failure.…”

Section: Relevance Of Ae In Biotribological Diagnosismentioning

confidence: 99%

A review of acoustic emission as a biotribological diagnostic tool

Olorunlambe

Shepherd

Dearn

2019

Tribology - Materials, Surfaces & Interfaces

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Acoustic emission (AE) testing has been used in the detection of the onset and progression of mechanical flaws. It has also proven advantageous in the tribological assessment of mechanical systems and human joints as well as for implant condition monitoring. Current modes of diagnosing implant failures are becoming less effective and time consuming calling for the development of a more effective and dynamic diagnostic method. This review aims to provide an overview of the current tribological applications of AE and to highlight how this can be instrumental in the development of a more effective failure diagnosis method. It can be concluded that AE has potential capabilities as a tool for monitoring the tribological phenomenon of artificial joints which would not only allow for a more effective way of diagnosing implant failures but also for diagnosing natural joint diseases such as back pain and arthritis.

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Section: Relevance Of Ae In Biotribological Diagnosismentioning

confidence: 99%

A review of acoustic emission as a biotribological diagnostic tool

Olorunlambe

Shepherd

Dearn

2019

Tribology - Materials, Surfaces & Interfaces

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Orthopedic implant cobalt‐alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and zirconium alloy‐based particlesin vitro, in human osteoblasts, fibroblasts, and macrophages

Dalal

Pawar

McAllister

et al. 2012

J Biomedical Materials Res

109

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The performance of total joint arthroplasty (TJA) depends on the size/shape, material, and amounts of implant debris. Much remains unknown in terms of which types of debris are most reactive. We compared the responses of human periimplant cells, osteoblasts, fibroblasts, and macrophages, exposed to particles of different metal-based particles (i.e., cobalt-chromium-molybdenum (CoCrMo) alloy, titanium (Ti) alloy, zirconium (Zr) oxide, and Zr alloy. CoCrMo-alloy particles were by far the most toxic (p < 0.05) and decreased viability and proliferation of human osteoblasts, fibroblasts, and macrophages by >50% at a dose of only 50 particles per cell. All particle types induced the production of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-8 by osteoblasts, fibroblasts, and monocytes/macrophages. However, the greatest cytokine responses of macrophages were to CoCrMo alloy (TNF-α and IL-8) and Ti alloy (IL-1β). Likewise, the greatest responses of fibroblasts and osteoblasts were to CoCrMo alloy (IL-6 and TNF-α) (i.e., IL-6 300 pg/mL; 30-fold max, TNF-α 150 pg/mL; 15-fold max) versus controls. For macrophages, CoCrMo particles induced IL-8 (> 2000 pg/mL; approx 100-fold max) above controls and were also significantly elevated above levels produced by Zr-based particles. Submicron sized (0.2-0.9 μm) Zr-based particles (originally presumed to be more reactive) induced less toxicity and inflammatory responses when compared with larger (approx 1 μm) CoCrMo-alloy and Ti-alloy particles.

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Stainless steel wear debris of a scoliotic growth guidance system has little local and systemic effect in an animal model

Singh

Rawlinson

Hallab

2018

Journal Orthopaedic Research

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Options to treat early-onset scoliosis include guided-growth systems with sliding action between rods and pedicle screws. The wear was previously measured in an in vitro test, and in this in vivo rabbit model, we evaluated the local and systemic biological response to the stainless steel debris. Compared to the previous study, a relatively higher volume of representative wear particles with a median particle size of 0.84 μm were generated. Bolus dosages were injected into the epidural space at L4-L5 for a minimum of 36 rabbits across three treatment groups (negative control, 1.5 mg, and 4.0 mg) and two timepoints (12 and 24 weeks). Gross pathology evaluated distant organs and the injection site with a dorsal laminectomy to examine the epidural space and dosing site. Peri-implanted particle tissues were stained for immunohistochemical and quantitatively analyzed for IL-6 and TNF-α cytokines. Based on ISO 10993-6:2007 scoring, particles in the high-dose group were primarily non-irritant (12 weeks) with one slightly irritant. At 24 weeks, inflammatory cell infiltration was non-existent to minimal with all groups considered non-irritant at the injection site. Material characterization confirmed that particles detected in distant organs were stainless steel or contaminants. At 12 weeks, stainless steel groups demonstrated statistically increased amounts of cytokine levels compared to control but there was a statistical decrease for both at 24 weeks. These findings indicate that stainless steel wear debris, comparable to the expected usage from a simulated growth guidance system, had no discernible untoward biological effects locally and systemically in an animal model. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1980-1990, 2018.

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An In Vitro Assessment of Wear Particulate Generated From NUBAC

Cited by 10 publications

References 58 publications

A review of acoustic emission as a biotribological diagnostic tool

A review of acoustic emission as a biotribological diagnostic tool

Orthopedic implant cobalt‐alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and zirconium alloy‐based particlesin vitro, in human osteoblasts, fibroblasts, and macrophages

Stainless steel wear debris of a scoliotic growth guidance system has little local and systemic effect in an animal model

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