An In Vitro Comparison of Microbial Ingress Into 8 Different Needleless IV Access Devices

Abstract

There are conflicting reports of the effect needleless intravenous access devices have on rates of catheter-related bloodstream infection. The aim of this study was to identify any differences between the rates of microbial ingress into 8 different devices following contamination. Each type of device was subjected to a 7-day clinical simulation that involved repeated microbial contamination of the injection site and decontamination followed by saline flushes. Significant differences in the number of microorganisms associated with each device were detected in the saline eluates. Three positive-displacement mechanical valves were associated with the ingress of significantly fewer microorganisms compared with other devices.

The risk of microbial contamination associated with six different needle-free connectors

“…In this study, differences in the number of S. aureus detected in the saline flushes collected after passing through the various decontaminated needle-free connectors were demonstrated. Two connectors included in the authors' previous study had similar results to those in this current study in that there was no significant difference in the number of S. aureus recovered from BN and MC following 7 days of use (employing any decontamination regimen) (Casey et al, 2015). This confirms reproducibility of the test system used in the current study.…”

“…In total, 216 needle-free connectors were evaluated. The method used to evaluate the needle-free connectors and simulate the clinical scenario was carried out as previously described (Casey et al, 2015). In brief, each connector was subjected to the same 7 days of clinical simulation as outlined in Box 1 and were evaluated to encompass all the defined manufacturers' instructions for use.…”

“…negative-, positive-or neutral-displacement), but is device-(i.e. brand-) specific (Casey et al, 2015).…”

Anästhesiebezogene Hygiene und Infektionsprävention bei Operationen

“…Aktuelle Daten aus den USA unterstreichen: Ein Prolongieren der PAP > 24-48 h ist mit einer signifikanten Steigerung der Clostridioidesdifficile-Infektionen sowie mit einer höheren Inzidenz einer akuten Nierenschädigung verbunden [16]. [19]. Auch durch unterschiedliche Druckverhältnisse, die bei der Diskonnektion am NFC auftreten, können Nachteile entstehen [20].…”

Outbreak column 19: needleless connectors (NCs) tales from nine outbreaks

“…This NC does not have the desired fluid pathway characteristics advocated by Jarvis (2010). A recent in vitro study which looked at microbial ingress of eight NCs challenged with S. aureus found that the three positive displacement NCs had significantly less microbial ingress than the other five devices (Casey et al, 2015). Some non-randomised uncontrolled studies make vast claims or hint at problems which can be persuasive to NC purchasing decision-makers.…”