Background and Aim: This study aimed to assess the effect of G-Bond and Z-Prime Plus on fracture resistance of prefabricated zirconia posts bonded to root canal walls. Materials and Methods: This in-vitro experimental study evaluated 22 mandibular premolars with equal diameter and length. The teeth were cut at the cementoenamel junction (CEJ), underwent root canal treatment, and were randomly divided into two groups (n=11). One tooth from each group served as a control. Post space was prepared in the remaining teeth with a 10-mm length. Intracanal dentin was then etched, rinsed, and dried. Panavia F2 resin cement was applied to the canal. Z-Prime Plus and G-Bond were applied to the surfaces of zirconia posts in groups 1 and 2, respectively, and the posts were then cemented into the canals. The cores were built-up using Photo Core resin composite. The teeth underwent a compressive force applied to the central fossa of the core along their longitudinal axes at a crosshead speed of 0.5 mm/minute. The load at fracture was recorded. Data were analyzed using t-test considering their normal distribution. Result: The mean fracture resistance was 1094.2±328.0 N with G-Bond and 912.6±373.0 N with Z-Prime Plus; the difference was not significant (P=0.4). Conclusion: G-Bond and Z-Prime Plus were not significantly different in fracture resistance of zirconia posts bonded to root canal walls. However, G-Bond is recommended for this purpose since it had a lower coefficient of variation (CV) and slightly higher fracture resistance.