An in-vitro evaluation of C-di-GMP mediated biofilm dispersal as a potential strategy to restore antimicrobial efficacy

Abstract

My time spent in graduate school was a memorable undertaking, full of adventure, excitement, ups and downs, and mainly, a tremendous learning experience. In that sense, first and foremost, I would like to thank my supervisor, Assoc. Prof. Yang Liang, for showing me the path to do great science, for his guidance and his encouragement. I would like to thank my mentor, Assoc. Prof. Scott Rice, for his important advice. I would also like to thank my co-supervisor Assoc. Prof. Tan Choon Hong for his assistance along the way. I am especially grateful to Dr. Céline Vidaillac. Words cannot express my sincere, heartfelt gratitude for all of her efforts to assist me in my scientific endeavor and my career. I would like to thank her for her guidance and inspiration, for being a beacon in stormy seas. I thank the director of SCELSE, Prof. Staffan Kjelleberg, for his vision, managing a unique and unusual interdisciplinary center, and for the opportunity to take part in cutting-edge science. Thanks to SCELSE graduate programme director, Assoc. Prof. Sanjay Swarup, for his continued support and confidence in me. I also thank my former supervisor, Prof. Yehuda Cohen, for providing me the opportunity to partake in this research experience. Thanks to all the people at IGS for supporting my research and me. I would like to thank all of Prof. Yang's group members, my fellow Ph.D. students and predecessors. A special thank you to Chin Joyce and Seng Zi Jing, for their continued assistance to my research. Thanks to my dear friends, II colleagues and former colleagues in SCELSE: To Dr. Damien Keogh, also for taking the time and proofreading my thesis. Asst. Prof. Enrico Marsili, Dr.