An In Vitro Study of Local Oxygen Therapy as Adjunctive Antimicrobial Therapeutic Option for Patients with Periodontitis

Müller-Heupt, Lena Katharina; Eckelt, Anja; Eckelt, John; Groß, Joachim; Opatz, Till; Kommerein, Nadine

doi:10.3390/antibiotics12060990

Cited by 3 publications

(1 citation statement)

References 67 publications

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“…The goal of periodontal treatment is to preserve the surface material and morphology of the affected tooth while removing plaque biofilms in a minimally invasive manner. Currently, chemical agents, such as probiotics, ozone, and oxygen, that can help maintain oral health are available, but their use is always related to mechanical plaque removal 5 , 24 .…”

Section: Introductionmentioning

confidence: 99%

Effects of a new magnetostrictive ultrasonic scaler and a traditional piezoelectric ultrasonic scaler on root surfaces and patient complaints

You,

Wu,

Chen

2024

Sci Rep

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Tooth wear and pain are the primary concerns of patients undergoing periodontal scaling. The aims of this study were to compare the effects of a new magnetostrictive ultrasonic scaler and a traditional piezoelectric ultrasonic scaler on tooth surface roughness and calculus removal and to determine their impacts on patient discomfort during supragingival cleaning. This article had two parts: an in vitro study and a clinical study. In the in vitro study, thirty teeth with subgingival calculus were randomly assigned to two scaling treatment groups: magnetostrictive scalers (n = 15) and piezoelectric scalers (n = 15). Surface roughness measurements were taken at baseline and after scaling, and the root samples were visualised by SEM after scaling. Additionally, a single-centre randomised split-mouth clinical trial was conducted. Eighty-five participants diagnosed with chronic gingivitis or periodontitis were randomly assigned to receive supragingival scaling. The magnetostrictive scaler was used in half of the mouths (n = 85), and the piezoelectric scaler was used in the other half of the mouths (n = 85). Data on pain, noise, and vibration were collected using a VAS questionnaire, and the operating time was recorded. In both in vitro and clinical studies, magnetostrictive scalers were reported to be more effective than piezoelectric scalers in removing dental deposits (P < 0.05). Additionally, the root surface after scaling with the magnetostrictive scaler was smoother than that after scaling with the piezoelectric scaler in the in vitro study (P = 0.02). SEM examination also revealed that fewer dental materials were lost after instrumentation with the magnetostrictive scaler than after instrumentation with the piezoelectric scaler. Piezoelectric scalers caused less discomfort to patients in terms of pain, noise, and vibration than magnetostrictive scalers (P < 0.05). According to this clinical study, the magnetostrictive scaler caused more discomfort during supragingival scaling than the piezoelectric scaler. Moreover, the magnetostrictive scaler was also more efficient and produced a smoother root surface with less material loss after scaling than the piezoelectric scaler, as demonstrated in the in vitro study.

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Section: Introductionmentioning

confidence: 99%

Effects of a new magnetostrictive ultrasonic scaler and a traditional piezoelectric ultrasonic scaler on root surfaces and patient complaints

You,

Wu,

Chen

2024

Sci Rep

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Antimicrobial and antibiotic-potentiating effect of calcium peroxide nanoparticles on oral bacterial biofilms

Bankar,

Latta,

Loretz

et al. 2024

npj Biofilms Microbiomes

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Bacterial biofilms represent a prominent biological barrier against physical and chemical attacks. Disturbing the anaerobic microenvironment within biofilms by co-delivery of oxygen appears as a promising strategy to enhance the activity of an antibiotic. Here, we report the effect of oxygen-producing calcium peroxide nanoparticles (CaO2 NP) in combination with tobramycin sulfate (Tob). On Pseudomonas aeruginosa PAO1 biofilms in vitro, the additive effect of CaO2 NP towards Tob activity enhanced biofilm eradication by 2 log compared to Tob alone. For natural biofilms grown in the oral cavity of human volunteers in situ, treatment by CaO2 NP alone slightly increased the fraction of dead bacteria from 44% in various controls, including Tob alone, to 57%. However, the combination of CaO2 NP with Tob further increased the fraction of dead bacteria to 69%. These data confirm the intrinsic antimicrobial and antibiotic-potentiating effect of CaO2 NP also in a clinically relevant setting.

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Detection of Oronasal Fistula Using a Fluorescent Water Passing Test

Ogawa,

Yamaki,

Yamashita

et al. 2024

J Vet Dent

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The confirmation of a connection between the oral and nasal cavities provides a definitive diagnosis for an oronasal fistula (ONF). However, visual detection is difficult in patients with small fistulas. This study examined whether fluorescein sodium could be used to detect small ONFs. The study included 25 dogs that underwent dental examination and had confirmed periodontal pockets at the Amica Pet Clinic, Japan, between 2020 and 2022. Saline containing fluorescein sodium was injected into the periodontal pocket, termed a fluorescent “water-passing test,” followed by detection of fluid discharge from the external naris using an examination light. Of the 25 dogs, 13 showed symptoms consistent with an ONF and of these, 12 were positive and one was negative on the fluorescent water-passing test. Of the 12 asymptomatic dogs, 3 tested positive and 9 tested negative on the fluorescent water-passing test. The fluorescent water-passing test enhanced visibility and facilitated the detection of small volumes of the discharged fluid. The results of this study confirmed the fluorescent water-passing test was useful for the detection of small ONFs.

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An In Vitro Study of Local Oxygen Therapy as Adjunctive Antimicrobial Therapeutic Option for Patients with Periodontitis

Cited by 3 publications

References 67 publications

Effects of a new magnetostrictive ultrasonic scaler and a traditional piezoelectric ultrasonic scaler on root surfaces and patient complaints

Effects of a new magnetostrictive ultrasonic scaler and a traditional piezoelectric ultrasonic scaler on root surfaces and patient complaints

Antimicrobial and antibiotic-potentiating effect of calcium peroxide nanoparticles on oral bacterial biofilms

Detection of Oronasal Fistula Using a Fluorescent Water Passing Test

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