An In Vitro Study of Different Types of Greek Honey as Potential Natural Antimicrobials against Dental Caries and Other Oral Pathogenic Microorganisms. Case Study Simulation of Oral Cavity Conditions

Voidarou, C.; Αντωνιάδου, Μαρία; Rozos, Georgios; Alexopoulos, Athanasios; Giorgi, Elpida; Tzora, Athina; Skoufos, Ioannis; Varzakas, Theodoros; Bezirtzoglou, Eugenia

doi:10.3390/app11146318

Cited by 13 publications

(18 citation statements)

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“…The results indicated that the Saturja spp. and the oregano and sage honeys exhibited a greater antibacterial activity against the tested bacteria than Manuka honey [60].…”

Section: Honeymentioning

confidence: 86%

“…Strong activity of honey is also observed against A. viscous, A. actinomycetemcomi The graph shows mean MIC values ± SEM for honey and royal jelly expressed in % for the bacterial strains causing oral cavity infections. Only experiments in which the MIC value was determined in % were included in the analysis [5,41,43,44,46,48,49,52,54,56,[58][59][60]. (B) The graph shows mean MIC values ± SEM for honey, royal jelly, and bee venom expressed in µg/mL for the bacterial strains causing oral cavity infections.…”

Section: Bee Venommentioning

confidence: 99%

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Bee Venom, Honey, and Royal Jelly in the Treatment of Bacterial Infections of the Oral Cavity: A Review

Otręba

Marek

Tyczyńska

et al. 2021

Life

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Oral diseases affect a very large number of people, and the applied pharmacological methods of treatment and/or prevention have serious side effects. Therefore, it is necessary to search for new, safer methods of treatment. Natural bee products, such as honey, royal jelly, and bee venom, can be a promising alternative in the treatment of oral cavity bacterial infections. Thus, we performed an extensive literature search to find and summarize all articles about the antibacterial activity of honey, royal jelly, and bee venom. Our analysis showed that these bee products have strong activity against the bacterial strains causing caries, periodontitis, gingivitis, pharyngitis, recurrent aphthous ulcers, supragingival, and subgingival plaque. An analysis of average MIC values showed that honey and royal jelly have the highest antimicrobial activity against Porphyromonas gingivalis and Fusobacterium nucleatum. In turn, bee venom has an antibacterial effect against Streptococcus mutans. Streptococcus sobrinus and Streptoccus pyogenes were the most resistant species to different types of honey, and royal jelly, respectively. Moreover, these products are safer in comparison to the chemical compounds used in the treatment of oral cavity bacterial infections. Since the antimicrobial activity of bee products depends on their chemical composition, more research is needed to standardize the composition of these compounds before they could be used in the treatment of oral cavity bacterial infections.

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“…The results indicated that the Saturja spp. and the oregano and sage honeys exhibited a greater antibacterial activity against the tested bacteria than Manuka honey [60].…”

Section: Honeymentioning

confidence: 86%

Section: Bee Venommentioning

confidence: 99%

Bee Venom, Honey, and Royal Jelly in the Treatment of Bacterial Infections of the Oral Cavity: A Review

Otręba

Marek

Tyczyńska

et al. 2021

Life

View full text Add to dashboard Cite

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“…Although the studies performed have suggested the limited efficacy of honey against S. mutans , a very recent laboratory observation with different Greek honey types and manuka honey revealed that all tested honey samples were highly effective against S. mutans [ 53 ]. The average MIC values of citrus (n = 20), Satureja spp.…”

Section: Honey—its Composition and Antibacterial/antibiofilm Propertiesmentioning

confidence: 99%

Antibacterial and Antibiofilm Effect of Honey in the Prevention of Dental Caries: A Recent Perspective

Deglovic

Majtánová

Majtán

2022

Foods

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The successful application of honey in wound care management has been achieved due to honey’s potent antibacterial effects, characterised by its multifactorial action. Impressive clinical efficacy has ignited its further use in diverse clinical disciplines, including stomatology. Indeed, there is increasing usage of honey in dental medicine as a preventive or therapeutic remedy for some periodontal diseases mainly associated with bacteria, such as dental caries, gingivitis and mucositides. Dental caries is undoubtedly a major oral health problem worldwide, with an increasing tendency of incidence. The purpose of this perspective review is to describe the recent progress in the laboratory and clinical use of honey in the prevention of dental caries, with emphasis on the antibacterial and antibiofilm effects of honey. The role of honey in the cariogenic process is also discussed. In addition, the quality of honey and the urgent in vitro evaluation of its antibacterial/antibiofilm properties before clinical use are highlighted. Findings based on data extracted from laboratory studies demonstrate the pronounced antibacterial effect of different honeys against a number of periodontal pathogens, including Streptococcus mutans. Although the promising antibiofilm effects of honey have been reported mainly against S. mutans, these results are limited to very few studies. From a clinical point of view, honey significantly reduces dental plaque; however, it is not superior to the conventional agent. Despite the positive in vitro results, the clinical effectiveness of honey in the prevention of dental caries remains inconclusive since further robust clinical studies are needed.

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“…), oregano and sage honeys, originated from Epirus Greece, were significantly antimicrobial towards S. aureus ATCC 12600, S. mutans and F. nucleatum . (Voidarou et al., 2021a). Greek pine honey (pH 3.4) was also highly antibacterial against S. marcescens and E. coli comparing to other European (Spanish, British, New Zealand), Cuban, Chilean and Australian honeys (Alnaimat et al., 2012; Serin et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

The antimicrobial mechanism of Greek thyme honeys against methicillin‐resistant Staphylococcus aureus clinical isolates: a case study of comparison with Manuka honey

Masoura

Gkatzionis

2022

Int J of Food Sci Tech

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Summary The antibacterial potential of honey has been of great scientific interest. Understanding the underlying mechanism is essential to explore its potential as therapeutic alternative against a range of (non)pathogenic microorganisms. The floral origin of honey is critical for its antibacterial activity and Greek thyme honeys have been of increasing interest due to their chemical composition and bioactivity. In this study, the antimicrobial effect of six Greek honeys, with different percentages of thyme pollen grains and two Manuka honeys were tested against four MRSA clinical isolates (ATCC 43300, 0791, 28965, 01322). Agar‐well diffusion assay and total viable counts were used to examine the antimicrobial strength of honeys, while the effect thereof on cellular redox state and cell membrane was tested by flow cytometry. Thyme honeys had superior or equal antimicrobial strength compared to this of Manuka, while thermal processing did not significantly affect this activity. Acidity and the high H2O2 content, common features for all thyme honeys, caused cellular oxidative damage and cell death unlike observed in Manuka‐treated populations. The activity of the monofloral thyme honey (74% thyme pollen) was higher than the other indigenous polyfloral samples, which confirms the medicinal importance of this medicinal plant.

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An In Vitro Study of Different Types of Greek Honey as Potential Natural Antimicrobials against Dental Caries and Other Oral Pathogenic Microorganisms. Case Study Simulation of Oral Cavity Conditions

Cited by 13 publications

References 94 publications

Bee Venom, Honey, and Royal Jelly in the Treatment of Bacterial Infections of the Oral Cavity: A Review

Bee Venom, Honey, and Royal Jelly in the Treatment of Bacterial Infections of the Oral Cavity: A Review

Antibacterial and Antibiofilm Effect of Honey in the Prevention of Dental Caries: A Recent Perspective

The antimicrobial mechanism of Greek thyme honeys against methicillin‐resistant Staphylococcus aureus clinical isolates: a case study of comparison with Manuka honey

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