An in vitro study on reproductive toxicity of aluminium chloride on rabbit sperm: The protective role of some antioxidants

Yousef, Mokhtar I.; Kamel, Kamel I.; El-Guendi, Marwa I.; El‐Demerdash, Fatma M.

doi:10.1016/j.tox.2007.07.011

Cited by 81 publications

(48 citation statements)

References 43 publications

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“…Our data support this hypothesis; both TBARS and HP levels were found to be elevated in AlCl 3 -treated rats while GSH, SOD and CAT activity were decreased in the liver and kidney. These observations are similar to previously published findings demonstrating that aluminum intake promoted oxidative stress [57][58][59][60] . Although aluminum is not a transition metal, and therefore, cannot initiate peroxidation, many studies have searched for a correlation between aluminum accumulation and oxidative damage in tissues [60][61][62] .…”

Section: Discussionsupporting

confidence: 93%

Camel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino Rats

Al‐Hashem¹

2009

American Journal of Biochemistry and Biotechnology

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Problem statement: Aluminum chloride (AlCl 3 ) is commonly used in daily life but it can be potentially toxic. Therefore, the present study was carried out to investigate the protective effects of camel's milk against aluminum-induced biochemical alterations and oxidative stress in the liver and kidney of white albino rats. Approach: White albino male rats (230-250 g) were divided into three groups of 10 rats: a control group treated with normal saline, the AlCl 3 -treated group and the camel's milk-AlCl 3 -treated group. The AlCl 3 treated group received 0.5 mg kg −1 of AlCl 3 orally. The camel's milk-AlCl 3 -treated group was fed 1 mL of fresh camel's milk 10 minutes prior to the administration of oral AlCl 3 . All rats were treated every day for 30 days. Liver and kidney biochemical serum parameters were analyzed. Lipid peroxidation, as determined by the tissue concentrations of thiobarbituric acid reactive substances (TBARS) and hydrogen peroxide (HP), and the oxidative stress status, as measured by glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) activity, were evaluated in the kidney and liver of treated rats. Results: Data showed that the oral administration of AlCl 3 resulted in statistically significant increases in the serum levels of urea, creatinine, bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), cholesterol and triglycerides; the total amount of protein and albumin were also significantly decreased. However, these parameters were within normal levels in the rats given camel's milk prior to AlCl 3 . Additionally, oral administration of AlCl 3 induced lipid peroxidation in the liver and kidney, which was indicated by a significant increase in lipid peroxidation biomarkers (TBARS and HP) and a significant decrease in the activities of GSH, SOD and CAT. In all rats treated with camel's milk before being given AlCl 3 , lipid peroxidation and oxidative stress parameters were within normal levels. Conclusion: Treatment with camel's milk prior to AlCl 3 exposure alleviates AlCl 3 -associated hazards and protects the kidney and liver from AlCl 3 toxicity.

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Section: Discussionsupporting

confidence: 93%

Camel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino Rats

Al‐Hashem¹

2009

American Journal of Biochemistry and Biotechnology

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“…AlCl 3 also decreases antioxidant parameters such as GSH, SOD, and CAT in the liver of rats. These observations are similar to those of previous studies demonstrating that aluminum intake promoted oxidative stress (Nehru and Anand 2005;Yousef et al, 2007) . Another study reported that exposure to aluminum disrupted the mineral balance, resulting in aluminum ions replacing iron and magnesium and leading to reduced Fe 2+ binding to ferritin (Ward et al, 2001).…”

Section: Journal Of Biology and Life Sciencesupporting

confidence: 92%

Protective Effects of Açai in Combination with Vitamin C against Aluminum-Induced Toxicity in Rat Liver

Ahmed

Hamaad²

2017

JBLS

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Aluminum is associated with the pathogenesis of several diseases. Aç ai has recently emerged as a natural source of antioxidants. The present study was conducted to evaluate the protective effect of Aç ai in combination with vitamin C against the aluminum chloride induced toxicity. Seventy rats were divided into 7 groups:-Group (GP) 1: control group, GP 2: treated with AlCl3, GP 3: treated with Aç ai, GP 4: treated with vitamin C, GP 5: treated with AlCl3 and Aç ai , GP 6: treated with AlCl3 and vitamin C, GP 7: treated with AlCl3, Aç ai and vitamin C. After 4 weeks, blood and liver specimens were collected to evaluate biochemical alterations and hepatic antioxidant and inflammatory parameters. AlCl3 treatment decreased liver enzymes (alanine aminotransferase, aspartate amino transferase, alkaline phosphatase), tumor necrosis factor-α and IL-6 while hepatic malondialdehyde was elevated. In contrast, hepatic glutathione, super oxide dismutase, catalase were decreased. Aç ai and vitamin C treatment improved the adverse effects induced by AlCl3, while co-administration with vitamin C promoted the action of aç ai on hepatic damage and antioxidant parameters. Aç ai showed a protective effect against AlCl3 induced toxicity, particularly in combination with vitamin C.

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“…It has been reported that there is a strong correlation between high aluminum contents in human testes, Leydig cells, spermatozoa, seminal plasma, blood and urine with impaired sperm quality and viability [21][22][23] . Suppressed testosterone production, sexual behavior and fertility were also observed in animals exposed to aluminum [24][25][26] . Necrosis of spermatocytes and a significant decrease in fertility were demonstrated in male mice treated intraperitoneally with aluminumnitrate [27] .…”

Section: Introductionmentioning

confidence: 92%

“…A significant decrease in ejaculate volume, sperm concentration, total sperm output, sperm motility, total motile sperm per ejaculate, packed sperm volume, total functional sperm fraction, normal and live sperm and an increase in dead and abnormal sperm were all demonstrated in a study of Yousef et al evaluating rabbits orally administered AlCl 3 [25] . Furthermore, AlCl 3 exposure can lead to testicular injuries, especially as a result of increased oxidative stress [25][26][27][28] . Exley [29] and Yousef et al [25] have reported that aluminum exerts a pro-oxidant activity and promotes oxidation both in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 99%

Camel’s Milk Alleviates Oxidative Stress and Lipid Peroxidation Induced by Chronic Aluminum Chloride Exposure in Rat’s Testes

Al‐Hashem¹

2009

American J. of Applied Sciences

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Problem statement: The present study was carried out to examine the effectiveness of Camel's milk in alleviating aluminum chloride (AlCl 3 )-induced oxidative stress and lipid peroxidation in rat testes. Approach: White albino male rats (230-250 g) were divided into three groups of 10 rats: A control group, treated with normal saline and two experimental groups, the AlCl 3 treated group and the Camel's milk-AlCl 3 treated group. The first experimental group, the AlCl 3 treated group, received 0.5 mg kg −1 of AlCl 3 orally. The second experimental group was fed 1 mL of fresh Camel's milk 10 min prior to the administration of oral AlCl 3 . All rats were treated every day for 30 days. Lipid peroxidation, as determined by testicular concentration of Thiobarbituric Acid Reactive Substances (TBARS) and Hydroperoxide (HP) levels and the oxidative stress status, as measured by glutathione (GSH) levels, Superoxide Dismutase (SOD) and Catalase (CAT) activity, were evaluated in the rat testes. Results: Oral administration of AlCl 3 induced lipid peroxidation and oxidative stress in rat testes, which was indicated by a significant increase in lipid peroxidation biomarkers (TBARS and HP) and a significant decrease in the GSH content and SOD and CAT activities. When rats received Camel's milk before being given AlCl 3 , lipid peroxidation and oxidative stress parameters were restored to normal levels. In the testes from rats fed Camel's milk TBARS and HP levels were significantly reduced and, conversely, GSH content, SOD and CAT activities were significantly increased compared to rats that received only AlCl 3 . Conclusion: Treatment with Camel's milk prior to AlCl 3 alleviates AlCl 3 -associated hazards and protects testicular tissue from AlCl 3 toxicity.

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An in vitro study on reproductive toxicity of aluminium chloride on rabbit sperm: The protective role of some antioxidants

Cited by 81 publications

References 43 publications

Camel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino Rats

Camel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino Rats

Protective Effects of Açai in Combination with Vitamin C against Aluminum-Induced Toxicity in Rat Liver

Camel’s Milk Alleviates Oxidative Stress and Lipid Peroxidation Induced by Chronic Aluminum Chloride Exposure in Rat’s Testes

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