Purpose:The purpose of this study was to perform an in vitro evaluation of digital impressions using a mobile device and monoscopic photogrammetry in cases of orbital defects with undercuts. Methods: Three 10-mm-square cubes were attached to a diagnostic cast of a patient with a right orbital defect. Still images acquired with a mobile device were used to generate facial three-dimensional (3D) data. Two types of still images were used: one was a whole face image, and the other was a defect site-focused image. For comparison, an extraoral scanner was used to obtain facial 3D data. Five dental technicians fabricated 3D printed models using additive manufacturing and measured the distances between the measurement points using a digital caliper. The discrepancy between the distances measured on the diagnostic cast of the patient and the 3D printed model was calculated. Friedman test was used to analyze the discrepancy, and the Bonferroni test was used to verify the differences between the pairs. Results: Statistical significance was found with respect to the type of 3D model fabrication method. Conclusion: Within the limitations of this in vitro study, the results suggested that the workflow can be applied to digital impressions of the maxillofacial region.