An In Vivo Analysis of Reverse Ultrafiltration During High-Flux and High-Efficiency Dialysis

Hyver, Scott W.; Petersen, Jeffrey; Cajias, Jorge

doi:10.1016/s0272-6386(12)80951-6

Cited by 8 publications

(1 citation statement)

References 15 publications

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“…In these treatments (high-efficiency, high-flux hemodialysis and hemodiafiltration) the pressure profile along the dialysate path favors the movement of fluid from the dialysate to the blood. This process, called reverse ultrafiltration or backfiltration, is a reality and can easily be demonstrated to a lesser or greater extent in all of these treatments (3). Therefore, a potential path for patient contamination from the dialysate is more important -c-than it was in 1985.…”

Section: Water Quality?mentioning

confidence: 99%

Should Hemodialysis Fluid Be Sterile?

Bosch

1993

Seminars in Dialysis

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Section: Water Quality?mentioning

confidence: 99%

Should Hemodialysis Fluid Be Sterile?

Bosch

1993

Seminars in Dialysis

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Artificial Kidney, Modeling of Transport Phenomena in

Eloot

Verdonck

2006

Wiley Encyclopedia of Biomedical Engineering

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Patients suffering from renal failure can be treated with a renal replacement therapy. Although a possible transplantation is determined by the availability of kidney donors, peritoneal dialysis is only adequate for patients with sufficient remaining renal function. As a third alternative, hemodialysis therapy can be used in which the patient's blood is purified extracorporeally in a hemodialyzer. To have better insight in this blood purification modality, dialyzer geometry, membrane properties, fluid characteristics, and the basic transport phenomena are described. Focused on a hollow fiber dialyzer, an overview is given of models and experiments describing blood and dialysate flow on a macroscopic basis. Also, the physical models handling of microscopic phenomena like concentration polarization and mass transport are described. Finally, in‐house developed CFD (computational fluid dynamics) and experimental models are presented, which aim at optimizing dialyzer geometry by looking more in detail at transport processes and fluid properties inside the dialyzer. First, a macroscopic CFD model to visualize blood and dialysate flow distributions was developed and validated using SPECT (single‐photon emission‐computed tomography) medical imaging. Second, a microscopic numerical model was developed to describe flow and mass transport in a single dialyzer fiber. After model calibration and validation, the impact on solute removal of a variable fiber length and diameter was assessed for small and middle molecules. Also, the model was used to examine the effect of flow maldistribution by implementing the experimental SPECT results.

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Pros and Cons of Short, High Efficiency, and High Flux Dialysis

Barth

Replacement of Renal Function by Dialysis

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An In Vivo Analysis of Reverse Ultrafiltration During High-Flux and High-Efficiency Dialysis

Cited by 8 publications

References 15 publications

Should Hemodialysis Fluid Be Sterile?

Should Hemodialysis Fluid Be Sterile?

Artificial Kidney, Modeling of Transport Phenomena in

Pros and Cons of Short, High Efficiency, and High Flux Dialysis

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