An in vivo biocompatibility study of surgical meshes made from bacterial cellulose modified with chitosan

Piasecka-Zelga, Joanna; Zelga, Piotr; Szulc, Joanna; Wietecha, Justyna; Ciechańska, D.

doi:10.1016/j.ijbiomac.2018.05.123

Cited by 46 publications

(34 citation statements)

References 35 publications

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“…No inflammation at the implant site was observed through histopathological analysis neither acute irritation nor allergic reactions. On the contrary, a higher degree of fibroplasia (the growth of fibrous tissue) was observed (Piasecka‐Zelga et al ., ).…”

Section: Biocompatibility Of Bacterial Cellulosementioning

confidence: 97%

Bacterial cellulose: a versatile biopolymer for wound dressing applications

Portela

Leal

Almeida

et al. 2019

Microbial Biotechnology

435

271

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Summary Although several therapeutic approaches are available for wound and burn treatment and much progress has been made in this area, room for improvement still exists, driven by the urgent need of better strategies to accelerate wound healing and recovery, mostly for cases of severe burned patients. Bacterial cellulose (BC) is a biopolymer produced by bacteria with several advantages over vegetal cellulose, such as purity, high porosity, permeability to liquid and gases, elevated water uptake capacity and mechanical robustness. Besides its biocompatibility, BC can be modified in order to acquire antibacterial response and possible local drug delivery features. Due to its intrinsic versatility, BC is the perfect example of a biotechnological response to a clinical problem. In this review, we assess the BC main features and emphasis is given to a specific biomedical application: wound dressings. The production process and the physical–chemical properties that entitle this material to be used as wound dressing namely for burn healing are highlighted. An overview of the most common BC composites and their enhanced properties, in particular physical and biological, is provided, including the different production processes. A particular focus is given to the biochemistry and genetic manipulation of BC. A summary of the current marketed BC‐based wound dressing products is presented, and finally, future perspectives for the usage of BC as wound dressing are foreseen.

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Section: Biocompatibility Of Bacterial Cellulosementioning

confidence: 97%

Bacterial cellulose: a versatile biopolymer for wound dressing applications

Portela

Leal

Almeida

et al. 2019

Microbial Biotechnology

435

271

View full text Add to dashboard Cite

show abstract

“…Further incorporation of inorganic (Ag [114], ZnO [114], CuO [115] and TiO 2 particles [116]) and organic antimicrobial agents (lysozyme [117], ε-poly lysine [53], nisin [118] garlics’ allicin [119]), evoke their effectiveness against several bacterial strains ( Staphylococcus aureus and Escherichia coli ), as well as fungal strains ( Aspergilus niger and Candida albicans ). Abdominal hernia treatment is another application of BC as a dressing material, where better absorption in native tissue with less risk of mesh-related infections, impact and hypersensitivity at the implant site were reported [120].…”

Section: Bc In Regenerative Medicinementioning

confidence: 99%

Bacterial Cellulose: Production, Modification and Perspectives in Biomedical Applications

2019

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Bacterial cellulose (BC) is ultrafine, nanofibrillar material with an exclusive combination of properties such as high crystallinity (84%–89%) and polymerization degree, high surface area (high aspect ratio of fibers with diameter 20–100 nm), high flexibility and tensile strength (Young modulus of 15–18 GPa), high water-holding capacity (over 100 times of its own weight), etc. Due to high purity, i.e., absence of lignin and hemicellulose, BC is considered as a non-cytotoxic, non-genotoxic and highly biocompatible material, attracting interest in diverse areas with hallmarks in medicine. The presented review summarizes the microbial aspects of BC production (bacterial strains, carbon sources and media) and versatile in situ and ex situ methods applied in BC modification, especially towards bionic design for applications in regenerative medicine, from wound healing and artificial skin, blood vessels, coverings in nerve surgery, dura mater prosthesis, arterial stent coating, cartilage and bone repair implants, etc. The paper concludes with challenges and perspectives in light of further translation in highly valuable medical products.

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“… Applicable items including but not limited to cleaning process and impurity removal process, and weaving process. Biocompatibility [ 110 ] Toxicological response caused by poor biocompatibility. Evaluation without performing biological tests: toxicological equivalence analysis with similar products on the Chinese market, toxicological analysis of leachable substances.…”

Section: Current Statusmentioning

confidence: 99%

Regulatory science for hernia mesh: Current status and future perspectives

Liu

Xie

Zheng

et al. 2021

Bioactive Materials

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Regulatory science for medical devices aims to develop new tools, standards and approaches to assess the safety, effectiveness, quality and performance of medical devices. In the field of biomaterials, hernia mesh is a class of implants that have been successfully translated to clinical applications. With a focus on hernia mesh and its regulatory science system, this paper collected and reviewed information on hernia mesh products and biomaterials in both Chinese and American markets. The current development of regulatory science for hernia mesh, including its regulations, standards, guidance documents and classification, and the scientific evaluation of its safety and effectiveness was first reported. Then the research prospect of regulatory science for hernia mesh was discussed. New methods for the preclinical animal study and new tools for the evaluation of the safety and effectiveness of hernia mesh, such as computational modeling, big data platform and evidence-based research, were assessed. By taking the regulatory science of hernia mesh as a case study, this review provided a research basis for developing a regulatory science system of implantable medical devices, furthering the systematic evaluation of the safety and effectiveness of medical devices for better regulatory decision-making. This was the first article reviewing the regulatory science of hernia mesh and biomaterial-based implants. It also proposed and explained the concepts of evidence-based regulatory science and technical review for the first time.

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An in vivo biocompatibility study of surgical meshes made from bacterial cellulose modified with chitosan

Cited by 46 publications

References 35 publications

Bacterial cellulose: a versatile biopolymer for wound dressing applications

Bacterial cellulose: a versatile biopolymer for wound dressing applications

Bacterial Cellulose: Production, Modification and Perspectives in Biomedical Applications

Regulatory science for hernia mesh: Current status and future perspectives

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