An in-vivo experimental model for studying wound-healing after laser irradiation in the mouse foetus

Suzuki, Shigehiko; Itoh, Kouichi; Ohyama, Kimie

doi:10.1016/j.jcms.2004.02.001

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…Epithelial detachment and a relatively large tissue loss extending to the muscle tissue region were seen at 1 day PW as previously described (Suzuki et al , 2004) (data not shown), but re‐epithelialization of the skin was completed on the wounded side at d 2 PW. Subepithelial mesenchymal cells in the dermis started to migrate from the surrounding normal tissue but the wounded region was still identified.…”

Section: Resultssupporting

confidence: 78%

“…The wounds for two groups of ICR mice were studied. Postnatal wounds were created on day 5 after birth (d 5) (21 samples) and fetal wounds were created on embryonic day 14 (E 14) (12 samples) according to the results from a previous study (Suzuki et al , 2004): note, as preliminary experiments, we obtained high mortality in less than E 14 postoperatively, and scar tissue remained in fetuses operated in later period of pregnancy as well as postnatal, in addition, since mice d 5 are relatively young and easy to handle. After the operation, the postnatal and pregnant mice were individually caged and postoperatively fed a standard rodent chow and water ad libitum .…”

Section: Methodsmentioning

confidence: 99%

“…Suzuki et al (2004) established a fetal mouse wound healing model of the naso‐labial region using argon laser. This laser wounding model is different from other wound healing models such as incisions in thermal injury induced and in the larger area of tissue necrosis, but this model can easily make fetal wound without disrupting amniotic sacs and dynamic histological changes can be observed in severe injury rather than simple incision.…”

Section: Introductionmentioning

confidence: 99%

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Laser burn wound healing in naso‐labial region of fetal and neonatal mice

et al. 2007

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Section: Resultssupporting

confidence: 78%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Laser burn wound healing in naso‐labial region of fetal and neonatal mice

et al. 2007

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“…Various protocols are taken advantage of in other studies which have offered acceptable results. 20,21…”

Section: Discussionmentioning

confidence: 99%

Effect of Low-level Laser Therapy on Neurosensory Disorders Recovery following the Bilateral Sagittal Split Ramus Osteotomy

Kiani¹,

Derakhshan²,

Abasi³

et al. 2015

International Journal of Laser Dentistry

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Introduction: Bilateral sagittal split osteotomy (BSSO) is a technique commonly used to correct mandibular disproportions, while neurosensory disorders are common following this technique. Low-level laser irradiation has shown promising results to relieve the neurosensory disorders of BSSO technique. Objective:The aim of this study was to compare the effects of low-level laser irradiation on the neurosensory complications related to the BSSO technique. Materials and methods:In this prospective, double-blinded clinical trial, 13 patients candidate for BSSO surgery were selected and went under complete clinical neurosensory tests (CNTs) including brush stroke discrimination; two-point discrimination; and contact, thermal, and pinprick discrimination, as well as visual analog scale (VAS) assessments. The laser GaAlAs (820-830 µm wavelength) irradiation was done for total six sessions after surgery for the patients at one side accidentally, and the opposite site was a control by irradiation of placebo. The values of CNT assessments between the experimental and control sites were analyzed employing Wilcoxon signed-rank test.Results: Higher values of VAS and brush stroke discrimination test were observed in the laser-irradiated sites than in the control sites, although without any significant differences (p > 0.05). Moreover, significantly higher values of pinprick discrimination test were noted in the experimental sites on days 1, 2, 3, 4, 7, 14, 28, and 60 (p < 0.05). The thermal test results were higher in the study sides, and the differences of both sides were significant on days 2, 3, 4, 7, 14, and 28 (p < 0.05). Conclusion:In total, GaAlAs low-level laser irradiation after the BSSO surgery results in both subjective and objective improvements regarding the time and magnitude of return of function; however, in some tests no significant differences were found between laser-irradiated and control areas.

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