An in vivo model to assess factors that may stimulate the generation of an immune reaction to erythropoietin

Ryan, Mary H.; Heavner, George A.; Brigham-Burke, Michael; McMahon, Frank J.; Shanahan, Mary F.; Gunturi, Srinivas R.; Sharma, Basant; Farrell, Francis X.

doi:10.1016/j.intimp.2005.10.001

Cited by 37 publications

(22 citation statements)

References 16 publications

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“…Immunogenicity is a significant problem associated with protein therapeutics [60,61]. Due to artificial production processes, recombinant therapeutics are often not completely identical to their human native counterparts.…”

Section: Monitoring Antigenicity Of Therapeutic Drugsmentioning

confidence: 99%

Immunoproteomics: From biomarker discovery to diagnostic applications

Tjalsma

Schaeps

Swinkels

2008

Proteomics Clinical Apps

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Circulating antibodies reflect a molecular imprint of antigens that are related to autoimmune diseases, cancer or infection. Importantly, serum antibodies are useful clinical markers as they carry diagnostic information from all around the human body. Moreover, the amplification cascade governed by the humoral immune system causes a surplus of circulating antibodies after appearance of the corresponding (low abundance) antigen. In combination with the fact that antibodies are highly stable compared to many other serum proteins, they seem ideal to be implemented in clinical diagnostic assays for the detection of antigen-associated diseases. This review summarises advances in immunoproteomics with respect to technologies for biomarker discovery, with special emphasis on recently developed gel-free MS-based approaches, and looks forward to potential immunoproteomic applications in diagnostic medicine.

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Section: Monitoring Antigenicity Of Therapeutic Drugsmentioning

confidence: 99%

Immunoproteomics: From biomarker discovery to diagnostic applications

Tjalsma

Schaeps

Swinkels

2008

Proteomics Clinical Apps

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“…Between 1998 and 2000, nearly 200 cases of epoetin-associated PRCA cases were reported (21). Most cases occurred outside the United States and were attributed to the substitution of Tween in place of human serum albumin as a stabilizer for epoetin (22)(23)(24). The interaction of Tween with the uncoated rubber in prefilled syringes seems to cause leachates.…”

Section: Esa-induced Prcamentioning

confidence: 99%

Anemia of Chronic Kidney Disease

Singh¹

2008

Clinical Journal of the American Society of Nephrology

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“…1 Intensive analytical characterization of HSA-free batches of Epo was performed to understand this increase in immunogenicity. Association of Epo with polysorbate micelles, 2 formation of aggregates, 3 and the presence of leachates originating from the uncoated rubber plunger 4 were proposed as the main causes of immunogenicity. After introduction of a coated rubber plunger, contraindication of subcutaneous injection, and improvement of storage conditions, the rate of pure red-cell aplasia rapidly reached the initial background level.…”

Section: Introductionmentioning

confidence: 99%