An in vivo study of the biodistribution of gold nanoparticles after intervaginal space injection in the tarsal tunnel

Shi, Xiaoli; Zhu, Yuting; Hua, Wenda; Ji, Yinglu; Ha, Qing; Han, Xinxiao; Gao, Jingwei; Zhang, Qiang; Han, Dong; Ren, Keli; Wu, Xiaochun; Li, Hongyi; Han, Dong

doi:10.1007/s12274-016-1100-3

Cited by 27 publications

(22 citation statements)

References 36 publications

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“… The relative distribution proportion of Au NPs in the spleen, kidneys, lungs, intestines, and heart of SD rats at 5, 15, 30 min, 1, 4, 12, and 24 h after IVI (A) , and after ISI in the tarsal tunnel (B) . Adapted from Shi et al (2016) and Jia et al (2017) with permission. …”

Section: Toxicity Of Common Metallic and Metal Oxide Npsmentioning

confidence: 99%

The Toxicity Phenomenon and the Related Occurrence in Metal and Metal Oxide Nanoparticles: A Brief Review From the Biomedical Perspective

Attarilar

Yang

Ebrahimi

et al. 2020

Front. Bioeng. Biotechnol.

170

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Thousands of different nanoparticles (NPs) involve in our daily life with various origins from food, cosmetics, drugs, etc. It is believed that decreasing the size of materials up to nanometer levels can facilitate their unfavorable absorption since they can pass the natural barriers of live tissues and organs even, they can go across the relatively impermeable membranes. The interaction of these NPs with the biological environment disturbs the natural functions of cells and its components and cause health issues. In the lack of the detailed and comprehensive standard protocols about the toxicity of NPs materials, their control, and effects, this review study focuses on the current research literature about the related factors in toxicity of NPs such as size, concentration, etc. with an emphasis on metal and metal oxide nanoparticles. The goal of the study is to highlight their potential hazard and the advancement of green non-cytotoxic nanomaterials with safe threshold dose levels to resolve the toxicity issues. This study supports the NPs design along with minimizing the adverse effects of nanoparticles especially those used in biological treatments.

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Section: Toxicity Of Common Metallic and Metal Oxide Npsmentioning

confidence: 99%

The Toxicity Phenomenon and the Related Occurrence in Metal and Metal Oxide Nanoparticles: A Brief Review From the Biomedical Perspective

Attarilar

Yang

Ebrahimi

et al. 2020

Front. Bioeng. Biotechnol.

170

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“…173 It was earlier reported that the distribution of AuNPs in vivo is closely related to toxicity. 175 These nanoparticles are distributed to various organs and tissues before elimination and is largely dependent on the physicochemical properties including size, shape, surface charge, surface modification, and route of administration. 38,[176][177][178] Different sized nanoparticles (10, 50, 100, and 250 nm) accumulate in the liver after 24 hours, which could be linked to the high perfusion of blood through it.…”

Section: Uptake Biodistribution and Accumulation Of Aunpsmentioning

confidence: 99%

“…38,103 This suggests that uptake, biodistribution, and bioaccumulation studies on AuNPs provide more information on the applications of AuNPs in diagnosis and therapy rather than toxicity, as AuNPs are distributed and accumulate in various tissues and body fluids for short or extended periods without inducing toxicity. 34,103,107,175,180 Due to the extended exposure of the liver and spleen to the nanoparticles, inflammation, connective tissue formation or the presence of a large number of phagosomes should be investigated in toxicity studies of chronic exposure to nanoparticles.…”

Section: Factors Influencing the Toxicity Of Aunpsmentioning

confidence: 99%

Toxicological Behavior of Gold Nanoparticles on Various Models: Influence of Physicochemical Properties and Other Factors

et al. 2019

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Potential applications of gold nanoparticles in biomedicine have increasingly been reported on account of the ease of synthesis, bioinert characteristics, optical properties, chemical stability, high biocompatibility, and specificity. The safety of these particles remains a great concern, as there are differences among toxicity study protocols used. This article focuses on integrating results of research on the toxicological behavior of gold nanoparticles. This can be influenced by the physicochemical properties, including size, shape, surface charge, and other factors, such as methods used in the synthesis of gold nanoparticles, models used, dose, in vivo route of administration, and interference of gold nanoparticles with in vitro toxicity assay systems. Several researchers have reported toxicological studies with regard to gold nanoparticles, using various in vitro, in vivo, and in ovo models. The conflicting results concerning the toxicity of gold nanoparticles should thus be addressed to justify the safe use of gold nanoparticles in biomedicine.

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“…In recent years, the biological utilisation of the intervaginal space in medical applications has been emerging. [17][18][19][20] In particular, a previous study on the flow behavior of LMs in the connected fascial space (FS) showed that the IS in the FS system is a potential pathway to deliver drugs targeting certain regions of the body. 19 In this study, we introduced an LM, a gallium-based alloy, as an obstruction to reduce the CW invasion of BC in breast tumor-bearing mice.…”

Section: Introductionmentioning

confidence: 99%

Intervaginal space injection of a liquid metal can prevent breast cancer invasion and better-sustain concomitant resistance

Cao

Zhang

et al. 2020

Mater. Chem. Front.

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An in vivo study of the biodistribution of gold nanoparticles after intervaginal space injection in the tarsal tunnel

Cited by 27 publications

References 36 publications

The Toxicity Phenomenon and the Related Occurrence in Metal and Metal Oxide Nanoparticles: A Brief Review From the Biomedical Perspective

The Toxicity Phenomenon and the Related Occurrence in Metal and Metal Oxide Nanoparticles: A Brief Review From the Biomedical Perspective

Toxicological Behavior of Gold Nanoparticles on Various Models: Influence of Physicochemical Properties and Other Factors

Intervaginal space injection of a liquid metal can prevent breast cancer invasion and better-sustain concomitant resistance

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