1993
DOI: 10.1097/00007890-199303000-00030
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An Increase in Cytosolic Protease Activity During Liver Preservation Inhibition by Glutathione and Glycine

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Cited by 48 publications
(23 citation statements)
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“…It might be different from the generally accepted major pathways demonstrated in studies using proinflammatory mediators (36,61). Many intracellular events (production of ROS, ATP depletion, intracellular Ca 2ϩ accumulation, and activation of proteases) occur during hepatic I/R (20,21,33,41,66), and all of them can correlate with NF-B activation through dif- Fig. 4.…”
Section: Discussionmentioning
confidence: 89%
See 1 more Smart Citation
“…It might be different from the generally accepted major pathways demonstrated in studies using proinflammatory mediators (36,61). Many intracellular events (production of ROS, ATP depletion, intracellular Ca 2ϩ accumulation, and activation of proteases) occur during hepatic I/R (20,21,33,41,66), and all of them can correlate with NF-B activation through dif- Fig. 4.…”
Section: Discussionmentioning
confidence: 89%
“…I/R injury facilitates the depletion of ATP, the deterioration of intracellular Ca 2ϩ homeostasis (4,21), the activation of cytotoxic enzymes (proteases, phospholipases, arachidonic acid, etc.) (20), and the generation of reactive oxygen species (ROS) (17). However, little is known about the mechanism with which HS preconditioning or HSP-72 provides protection against hepatic I/R injury.…”
mentioning
confidence: 99%
“…Proteases (2)(3)(4)(5) as well as alteration in intracellular calcium concentration (2,6,7) have been found to play an important role in hepatic P͞Rp injury. Recent evidence suggests that calpain proteases are involved in the pathogenesis of anoxia͞reoxygenation or ischemia͞reperfusion injury in several animal models, including the brain (8), myocardium (9), and renal tubular cells (10).…”
mentioning
confidence: 99%
“…9,10,[12][13][14][15][16][19][20][21][32][33][34][35] Infiltrating neutrophils have been implicated as key mediators of I-R injury associated with numerous organs, including the intestine, heart, brain, skeletal muscle, and liver. 21,[36][37][38][39] The neutrophil is thought to have a central role, given the evidence that neutrophil elimination with vinblastin or blocking of neutrophil activity with mAb appears to be cytoprotective in the setting of I-R. 20,21 Our central hypothesis therefore was that RES dysfunction after I-R also was neutrophil dependent, at least to some degree.…”
Section: Discussionmentioning
confidence: 99%