An increase in salivary interleukin-6 level following acute psychosocial stress and its biological correlates in healthy young adults

Izawa, Shuhei; Sugaya, Nagisa; Kimura, Kenta; Ogawa, Namiko; Yamada, Kosuke; Shirotsuki, Kentaro; Mikami, Ikuyo; Hirata, Kazuo; Nagano, Yuichiro; Nomura, Shinobu

doi:10.1016/j.biopsycho.2013.06.006

Cited by 65 publications

(58 citation statements)

References 38 publications

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“…Therefore, we expected that the children would have an increase in the plasma concentration of the stress hormone cortisol, regardless of the diurnal rhythm, such as occurs in healthy young individuals exposed to a psychosocial stressor (Levine 2000;Izawa et al 2013;McEwen 2007). However, differential cortisol responses were noted based on the place of residence.…”

Section: Discussionmentioning

confidence: 98%

“…All blood samples were only taken in the morning between 11:00 and 12:30, immediately following the interview by the pediatrician and a physical examination. Due to the stressful nature of the forensic examination, an increase in plasma cortisol concentration above the expected diurnal rhythm was to be expected (Izawa et al 2013;McEwen 2007). To ensure conformity, after venesection of every patient, only the principle investigator was involved in all of the final procedures, namely, transfer of the sample to the laboratory for centrifugation (1,000×g for 10 min at 4°C), aliquoting the plasma, and placement of the sample in the freezer (−70°C).…”

Section: Venesection and Blood Handlingmentioning

confidence: 99%

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Cortisol and IL-6 Responses to Stress in Female Children Presenting at a Sexual Abuse Clinic

Muller

Errington

Szabo

et al. 2014

Journ Child Adol Trauma

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Since adults with histories of sexual abuse as children experience both dysregulation of cortisol and increased inflammatory markers, we hypothesized that plasma cortisol dysregulation and increased plasma IL-6 would be detectable at the first presentation of pre-pubertal girls to a sexual abuse clinic. Following the stressful forensic examination, the 11 patients recruited to the study had significantly different cortisol concentrations (p<0.0075), depending on whether they resided with family (309±101 nmol/l) or in a children's home (157±38 nmol/l). IL-6 was detected in all patients residing in a children's home, with plasma cortisol and IL-6 being inversely correlated (r=−0.8875). Our study demonstrates an association between decreased cortisol secretion, inflammation, and place of residence in sexually abused girls.

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Section: Discussionmentioning

confidence: 98%

Section: Venesection and Blood Handlingmentioning

confidence: 99%

Cortisol and IL-6 Responses to Stress in Female Children Presenting at a Sexual Abuse Clinic

Muller

Errington

Szabo

et al. 2014

Journ Child Adol Trauma

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“…Salivary levels of IL6, normally secreted under acute stress situations (IZAWA et al, 2013b), were decreased and stable in sheltered compared to owned dogs. In shelters, dogs live in collective stalls and present a hierarchic and social behavior, which allows the maintenance of a balanced emotional state.…”

Section: Task Different Authors Consider Different Cortisol Values Amentioning

confidence: 86%

“…Is there any relationship between IL6 and sociability? IL6 has been pointed out as a real indicator of acute stress (IZAWA et al, 2013b), and as a differentiator between shyness and stress. This stress is normal among dogs, not just in a fight dominance, but also in establishing hierarchy for joining the group.…”

Section: Discussionmentioning

confidence: 99%

“…Two factors are related to stress: interleukin 6 (IL6) to acute stress (HEINRICH et al, 2003;KUNZ-EBRECHT et al, 2003;CARROLL et al, 2011;CAMPISI et al, 2012;IZAWA et al, 2013b), and cortisol to chronic stress (BEERDA et al, 1997;BEERDA et al, 1999b;BEERDA et al, 2000;ACCORSI, 2008;AGUILERA, 2011). It has been reported that cortisol influences learning in dogs under stress (HAUBENHOFER; KIRCHENGAST, 2007;HAVERBEKE et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Correlação dos parâmetros endócrinos e comportamentais em cadelas abandonadas em programa de ressocialização

Lesnau¹

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Á DEUS, que no silêncio das madrugadas, permitiu-me conhecê-Lo, entendê-Lo e me ensinou a conversar com Ele. Volto para casa com minha fé descoberta e com uma experiência íntima muito forte estabelecendo esta aliança. Graças dou! À minha mãe Otilia Wisniewski Lesnau pelas vezes em que cruzou o Brasil para socorrer minha família na minha ausência e o apoio que sempre ofereceu. A todos vocês, muito obrigado! Epígrafe "Dizem que a oportunidade é uma deusa que tem cabelo na testa, portanto você tem de apanhá-la quando ela vem de frente porque depois que ela passa, a única coisa a fazer é se lamentar". The mechanism of stress is already known and can be divided in two stages: acute stress, which releases thermogenic factors and inflammatory -mediated interleukin 6 (IL6) and chronic stress, which suppresses the inflammatory response and is mediated by the presence of cortisol. When stray dogs are housed in shelters, they undergo a period of adaptation; however, until now there is not a ressocialization program at the governmental level aiming to improve their welfare along with their new owners. The ressocialization program beginning when dogs arrive to the shelter and the correlation of dogs´ behavior with physiological and endocrine parameters related to stress have not yet been described , which raises the hypothesis that it can decrease the traumatic impact of abandonment. Twenty seven healthy bitches were divided into 3 groups: with owners, abandoned not trained and abandoned trained.The trained and abandoned dogs were later adopted. The training lasted 15 min / day for 21 days. The behavioral assessment (ethogram and ethotest) was performed every 7 days and physiological parameters assessment (heart rate, respiratory rate, blood oxygenation rate, pulse) as well as saliva collection, daily. After the adoption, the bitches were evaluated for 7 additional days. Data were analyzed by ANOVA, after testing the results for normality. The correlation between parameters was analyzed using the Pearson correlation test. Values were considered different at p < 0.05. The most surprisingly result was the maintenance of low levels of IL6 in trained dogs after neutering, whereas the other two groups showed a significant increase of IL6. The consequences of training were evident in ethograms after adoption: there was an improvement of the interaction of dogs with the new family, attitudes of playing were more numerous, and dogs showed a greater receptivity to the new owners. The tail wagging, as communication behavior, appeared much more frequently in trained dogs after adoption. Abandoned dogs after adoption manifested more idleness, discouragement and depression behaviors and reduced alertness.These results suggest that the training reassures bitches in the stressful shelter environment, improves their physiological parameters, controls fear behaviors making them more able to adapt to the new environment after adoption. There were no differences in cortisol among the groups (p > 0.05). However, IL-6 concentration was lower in ...

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Interpersonal life stress, inflammation, and depression in adolescence: Testing Social Signal Transduction Theory of Depression

et al. 2020

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Background: Depression rates increase markedly for girls across the adolescent transition, but the social-environmental and biological processes underlying this phenomenon remain unclear. To address this issue, we tested a key hypothesis from Social Signal Transduction Theory of Depression, which posits that individuals who mount stronger inflammatory responses to social stress should exhibit greater increases in depressive symptoms following interpersonal life stress exposure than those who mount weaker inflammatory responses to such stress.Method: Participants were 116 adolescent girls (M age = 14.71) at risk for psychopathology, defined as having a history of mental health concerns (e.g., psychiatric treatment, significant symptoms) over the past 2 years. At baseline, we characterized their inflammatory reactivity to social stress by quantifying their salivary proinflammatory cytokine responses to a laboratory-based social stressor.Then, 9 months later, we assessed the interpersonal and noninterpersonal stressful life events that they experienced over the prior 9 months using an interview-based measure of life stress.Results: As hypothesized, greater interpersonal life stress exposure was associated with significant increases in depression over time, but only for girls exhibiting stronger salivary tumor necrosis factor-α and interleukin-1β reactivity to social stress. In contrast, noninterpersonal stress exposure was unrelated to changes in depression longitudinally, both alone and when combined with youths' cytokine reactivity scores.

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An increase in salivary interleukin-6 level following acute psychosocial stress and its biological correlates in healthy young adults

Cited by 65 publications

References 38 publications

Cortisol and IL-6 Responses to Stress in Female Children Presenting at a Sexual Abuse Clinic

Cortisol and IL-6 Responses to Stress in Female Children Presenting at a Sexual Abuse Clinic

Correlação dos parâmetros endócrinos e comportamentais em cadelas abandonadas em programa de ressocialização

Interpersonal life stress, inflammation, and depression in adolescence: Testing Social Signal Transduction Theory of Depression

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