An increasing incidence of type 1 diabetes mellitus in Romanian children aged 0 to 17 years

Şerban, Viorel; Brink, Stuart; Timar, Bogdan; Sima, Alexandra; Vlad, Mihaela; Timar, Romulus; Vlad, Adrian

doi:10.1515/jpem-2014-0364

Cited by 15 publications

(19 citation statements)

References 17 publications

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“…Alongside the inherited causes of HTG, the most important predisposing factors are high lipid and carbohydrate intake, lack of physical activity, and obesity 12. The negative impact that the metabolic syndrome (MS), dysglycemia, and abdominal obesity have on the level of TG is very well known 21–23.…”

Section: Discussionmentioning

confidence: 99%

“…Diabetes mellitus (DM) is a chronic, heterogeneous disease with a progressive evolution and multiple complications, its incidence being cited to have an important increase in the latest years 12. Besides the two main types of diabetes (type 1 and type 2), secondary types have been identified, among which one of the leading causes is represented by pancreatic diseases such as AP, chronic pancreatitis (CP), cystic fibrosis, or pancreatic cancer.…”

Section: Introductionmentioning

confidence: 99%

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Hypertriglyceridemia, an important and independent risk factor for acute pancreatitis in patients with type 2 diabetes mellitus

Albai¹,

Roman

Frandeș

2017

TCRM

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PurposeAcute pancreatitis (AP) is a frequent inflammatory disease of the pancreas with multiple causes, among which high triglyceride (TG) level is the most common. The main purpose of this study has been to research the prevalence of AP in patients with diabetes mellitus (DM) and to underline the importance of hypertriglyceridemia (HTG) as a risk factor in triggering AP. The possible link between AP and glycemic control has been studied also, alongside some cardiovascular risk factors and long-term diabetes complications.Patients and methodsThe patient cohort comprised 1,586 patients with DM, admitted to the Internal Medicine Clinic of Diabetes, Nutrition and Metabolic Disease within the Emergency Hospital in Timisoara between January and August 2016. Following a series of clinical and biological investigations, these patients were diagnosed with AP. The patients’ antidiabetic treatment and chronic diabetes-related complications have also been recorded.ResultsThe prevalence of pancreatitis in this group of patients was 3.7%. The presence of pancreatitis was associated with a higher HbA1c (8.5% vs 7.7%; P<0.001), fasting glycemia (167.5 vs 95 mg/dL; P<0.001), postprandial glycemia (244.5 vs 118 mg/dL; P<0.001), total cholesterol (256.5 vs 189.5 mg/dL; P<0.001), low-density lipoprotein cholesterol (LDLc) (208.7 vs 112.8 mg/dL; P<0.001), and TGs (495 vs 161 mg/dL; P<0.001). HDL cholesterol (HDLc) was found to be a significant protective factor against the risk of pancreatitis. On the contrary, high LDLc values were a significant risk factor for pancreatitis along with high non-HDLc and high TG values, respectively.ConclusionThe development of AP events in patients with DM is associated with unsatisfactory glycemic control, HTG, hypertension, and the presence and severity of DM chronic complications. In this study, the prevalence of AP events in patients with DM was 3.7%.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hypertriglyceridemia, an important and independent risk factor for acute pancreatitis in patients with type 2 diabetes mellitus

Albai¹,

Roman

Frandeș

2017

TCRM

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“…Diabetes mellitus (DM) is nowadays a major public health issue, with continuously increasing prevalence in both of its major two components: type 1 (T1DM) and T2DM 1,2. It is estimated that nowadays, 415 million adults are living with T2DM and that this number will increase to 642 million in 2040 1.…”

Section: Background and Aimsmentioning

confidence: 99%

Association between coping mechanisms and adherence to diabetes-related self-care activities: a cross-sectional study

Albai¹,

Sima²,

Papavă³

et al. 2017

PPA

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In the overall management of the most chronic diseases, including diabetes mellitus (DM), adherence to recommended disease-related self-care activities is of paramount importance. The diagnosis and presence of a chronic disease may be considered a difficult and stressful situation in life, a situation in which coping mechanisms are psychological processes developed at a conscious level to manage these situations. This study aimed to explore the possible relationship between the dominance of one of the four major coping styles and adherence to diabetes-related self-care activities (DRSCAs) in the population of patients with type 2 DM (T2DM). In a cross-sectional consecutive-case population-based study design, 126 patients previously diagnosed with T2DM were enrolled. Coping mechanisms were evaluated using the Cope scale inventory, which identifies the dominant coping mechanism: problem-, emotion-, social support-, or avoidance-focused. The quality of DRSCA was evaluated using the summary of diabetes self-care activities questionnaire, in which a higher score was associated with improved adherence. In the study cohort, 45 patients (35.7%) had problem-focused coping, 37 (29.4%) had emotion-focused coping, 32 (25.4%) social support-focused coping, and 12 (9.5%) had avoidance-focused coping. Patients with emotion-focused coping had the highest level (P=0.02) of DRSCA (median 44 points), followed by patients with social support-focused coping (median 40 points) and problem-focused coping (median 36 points), while patients with avoidance-focused coping had the lowest SDSCA total score (33 points). The type of dominant coping mechanism has a significant impact on the quality of the DRSCA measures implemented by the patient to manage their diabetes. Patients with emotion-focused and social support-focused coping styles tend to have significantly increased adherence to DRSCA scores, while patients with other dominant coping styles are less interested in managing their disease.

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“…Tao et al [12] proved that the prevalence of type 1 diabetes has been increased by 2-5% worldwide and its prevalence is approximately one in 300 in the USA by 18 years of age. Similarly, Serban et al [13] found the mean incidence being highest in the age group 10-14 years and the raise in incidence was noticed in all age groups except for 15-17 years.…”

Section: Discussionmentioning

confidence: 67%

Etiology, risk factors, clinical features, and pitfalls in the management of newly diagnosed diabetic children and adolescents

Hassan

Hafez

Koura³

et al. 2015

Medical Research Journal

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Objective The aim of this study was to identify the etiology, risk factors, and the most common clinical features of newly diagnosed diabetes in children and adolescents, in addition to the factors related to delayed diagnosis or mismanagement in these children.Materials and methods Ninety-nine children and adolescents aged from one month to 13 years with newly diagnosed type 1 diabetes (T1DM) were recruited from the inpatient department of the Diabetic, Endocrine, and Metabolic Pediatric Unit (DEMPU), New Children Hospital, Cairo University.Results Classic symptoms (polyuria and polydipsia, and weight loss) were the most common symptoms (the first two symptoms in 95.9 and the last one in 90.7%) preceding the diagnosis, and diabetic ketoacidosis was present in 51.5% of cases. Delayed and missed diagnosis was recorded in 49.5% of patients, with no significant relation with age, district of accommodation, or family history of diabetes. Cow's milk feeding was more frequent, being recorded in 75.2% vs. 19.6% with exclusive breast feeding, and positive family history of diabetes was recorded in 77.3%. Severity at presentation showed no significant relation with age, type of feeding, family history of diabetes, or C-peptide level.Conclusion Increased public awareness of early symptoms of diabetes is needed to reduce the frequency and severity of ketoacidosis. In addition, greater medical alertness to the possibility of T1DM in a young child should be stressed. Breastfeeding and avoidance of early cow milk introduction should be encouraged to decrease the risk for T1DM during infancy with its early complications and morbidity.

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An increasing incidence of type 1 diabetes mellitus in Romanian children aged 0 to 17 years

Abstract: Romania is a country with an intermediate incidence of type 1 diabetes mellitus in children, which is slightly higher in boys than in girls. The incidence of type 1 diabetes mellitus increased continuously during the 10-year survey, with the exception of the oldest teens.

Cited by 15 publications

References 17 publications

Hypertriglyceridemia, an important and independent risk factor for acute pancreatitis in patients with type 2 diabetes mellitus

Hypertriglyceridemia, an important and independent risk factor for acute pancreatitis in patients with type 2 diabetes mellitus

Association between coping mechanisms and adherence to diabetes-related self-care activities: a cross-sectional study

Etiology, risk factors, clinical features, and pitfalls in the management of newly diagnosed diabetic children and adolescents

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