An increasing proportion of the population is not covered by the current RDA for vitamin C – interrogation of EPIC-Norfolk and NHANES 2017/2018 cohorts

Carr, Anitra C.; Myint, Phyo Kyaw; Vijewardane, Samantha C.; Johnstone, Alexandra M.; Crook, Jennifer; Lykkesfeldt, Jens

doi:10.1080/10408398.2024.2356760

Critical Reviews in Food Science and Nutrition

2024

DOI: 10.1080/10408398.2024.2356760

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An increasing proportion of the population is not covered by the current RDA for vitamin C – interrogation of EPIC-Norfolk and NHANES 2017/2018 cohorts

Anitra C. Carr,

Phyo Kyaw Myint,

Samantha C. Vijewardane

et al.

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Cited by 3 publications

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Understanding the additional impact of prediabetes and type 2 diabetes mellitus on vitamin C requirements in people living with obesity

Carr,

Vlasiuk,

Zawari

et al. 2024

Nutrition Research

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Understanding the additional impact of prediabetes and type 2 diabetes mellitus on vitamin C requirements in people living with obesity

Carr,

Vlasiuk,

Zawari

et al. 2024

Nutrition Research

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Molecular Pharmacology of Vitamin C and Relevance to Health and Obesity—A Narrative Review

Wilson,

Liang,

Kaushal

et al. 2024

IJMS

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The role of food constituents as pharmacological agents is an important consideration in health and obesity. Vitamin C acts as a small molecule antioxidant but is also a co-factor for numerous transition metal-dependent enzymes involved in healthy weight and energy metabolism. Vitamin C cannot be manufactured by humans and is mainly obtained from the dietary intake of fresh fruit and vegetables. There is great variability between different nutritional guidelines in the recommended daily allowance of vitamin C. Vitamin C deficiency results from an inadequate intake of vitamin C-containing foods and also increased utilization by oxidative and carbonyl stress. Risk factors for vitamin C deficiency include cigarette smoking, malnutrition, obesity, type 2 diabetes mellitus, age, race, sex, social isolation, major surgery, and Western-type diets. Despite the common belief that vitamin C deficiency is rare in affluent countries, surveys of large populations and specific patient groups suggest otherwise. Patients with obesity typically consume highly processed, energy-dense foods which contain inadequate micronutrients. As obesity increases, larger amounts of oral vitamin C are required to achieve adequate plasma and tissue concentrations, as compared to persons with a healthy weight. This is important in the control of oxidative stress and the maintenance of homeostasis and organ function. In this narrative review, the dosage, absorption, distribution, excretion, and catabolism of vitamin C are reviewed, together with the latest findings on vitamin C pharmacology in patients with obesity.

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Nutraceutical Supplementation as a Potential Non-Drug Treatment for Fibromyalgia: Effects on Lipid Profile, Oxidative Status, and Quality of Life

de la Cruz Cazorla,

Blanco,

Rus

et al. 2024

IJMS

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Fibromyalgia (FM) is a chronic syndrome of unknown etiology, although many studies point to inflammation, oxidative stress, and altered mitochondrial metabolism as some of the cornerstones of this disease. Despite its socioeconomic importance and due to the difficulties in diagnosis, there are no effective treatments. However, the use of non-drug treatments is increasingly becoming a recommended strategy. In this context, the effects of supplementation of FM patients with an olive (poly)phenol, vitamin C, and vitamin B preparation were investigated in this work, analyzing complete blood count, biochemical, lipid, and coagulation profiles, and inflammation and oxidation status in blood samples. To gain a better understanding of the molecular mechanisms and pathways involved in the etiology of FM, a proteomic study was also performed to investigate the mechanisms of action of the supplement. Our results show that the nutraceutical lowers the lipid profile, namely cholesterol, and improves the oxidative status of patients as well as their quality of life, suggesting that this product could be beneficial in the co-treatment of FM. ClinicalTrials.gov (ID: NCT06348537).

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An increasing proportion of the population is not covered by the current RDA for vitamin C – interrogation of EPIC-Norfolk and NHANES 2017/2018 cohorts

Cited by 3 publications

References 51 publications

Understanding the additional impact of prediabetes and type 2 diabetes mellitus on vitamin C requirements in people living with obesity

Understanding the additional impact of prediabetes and type 2 diabetes mellitus on vitamin C requirements in people living with obesity

Molecular Pharmacology of Vitamin C and Relevance to Health and Obesity—A Narrative Review

Nutraceutical Supplementation as a Potential Non-Drug Treatment for Fibromyalgia: Effects on Lipid Profile, Oxidative Status, and Quality of Life

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