An incremental dosing protocol for women with severe vaginal trichomoniasis and adverse reactions to metronidazole

Pearlman, Mark D.; Yashar, Catheryn M.; Ernst, Susan; Solomon, William B.

doi:10.1016/s0002-9378(96)70329-0

Cited by 46 publications

(18 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Occasionally patients are allergic to metronidazole. Since there is no effective alternative, desensitization is the only option (18,85). Another therapeutic dilemma involves metronidazole resistance in T. vaginalis.…”

Section: Treatmentmentioning

confidence: 99%

Trichomoniasis

2004

View full text Add to dashboard Cite

Trichomoniasis is perhaps the most common curable sexually transmitted disease worldwide, yet few resources are devoted to its control. It is associated with potentially serious complications such as preterm birth and human immunodeficiency virus acquisition and transmission. The immunology of a related organism, Tritrichomonas foetus, which causes disease in cattle, has been investigated to some extent, but more work is needed for the human strain, Trichomonas vaginalis. In addition, although trichomoniasis is easily treated with oral metronidazole, there is concern that the number of strains resistant to this antibiotic are increasing, and currently no alternative is licensed in the United States. As more is appreciated concerning the important public health implications of this common infection, more work will need to be done in understanding the diagnosis, treatment, and immunology of this organism

show abstract

Section: Treatmentmentioning

confidence: 99%

Trichomoniasis

2004

View full text Add to dashboard Cite

show abstract

“…28 Metronidazole-resistant TV has reduced intracellular ferredoxin compared with susceptible strains. 29 A number of alternatives to oral metronidazole have been reported over the last three decades, a summary of the evidence for each shall be discussed: Increased dose/duration metronidazole: Intravenous metronidazole has been used to good effect, 30 but is probably unnecessary if oral treatment is possible. Vaginal metronidazole reduces symptoms but does not increase cure rates when used alone, 31 so is often combined with oral treatment.…”

Section: Discussionmentioning

confidence: 99%

Recalcitrant Trichomonas vaginalis infection – a case series

et al. 2005

View full text Add to dashboard Cite

The objective of this study was (1) to estimate the prevalence of recalcitrant Trichomonas vaginalis (TV) infection in a UK genitourinary medicine clinic; (2) to use a case series and literature review to suggest an algorithm for management of recalcitrant TV (rTV). A retrospective review of laboratory records, case-notes and literature review was conducted. Fifteen patients were studied, representing 1.16% of the cases presenting during the study period. A wide variety of therapeutic agents was used, the treatment regimen differed for each patient. No treatment was universally effective in achieving cure, but the use of acetarsol pessaries vaginally appeared to be the most frequently successful strategy. Based on these results, an algorithm for treatment of rTV is presented, although clinical trials will be needed to elucidate the best clinical approaches to this problem.

show abstract

“…In cases of true allergy, desensitization to metronidazole has been described in case reports and could be considered 66,67 (see Appendix 1 68 ). Recently, Helms et al 69 reported data collected from clinicians who consulted the CDC on 59 patients with suspected hypersensitivity to metronidazole.…”

Section: Allergymentioning

confidence: 99%