An InDel Polymorphism in Exon 6 of IGF2 Associated with the Breeding Value of Polish Holstein-Friesian Bulls

Flisikowski, Krzysztof; Adamowicz, Tatiana; Strabel, T.; Jankowski, Tomasz; Świtoński, M.; Zwierzchowski, L.

doi:10.1007/s10528-006-9071-9

Cited by 11 publications

(11 citation statements)

References 22 publications

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“…Differential expression of IGF2 already was known to be prevalent in the pathogenesis of the developmental disease BWS (Waterland et al 2006), and this study revealed epigenetic changes at the gene locus as a causative factor. As discussed earlier, this gene has been associated with several important traits in cattle, such as oocyte competency and milk yield (Flisikowski et al 2007;Fagundes et al 2011;Berkowicz et al 2012). Epigenetic changes in this gene could therefore have important implications for regulation of fertility and production traits in cattle.…”

Section: Epigenetics and Nutritionmentioning

confidence: 93%

“…Imprinting of murine Igf2 was lost in animals fed a synthetic diet deficient in methyl donors including vitamin B 12 (Waterland et al 2006) The IGF2 gene is associated with milk production and carcass traits in cattle (Flisikowski et al 2007;Berkowicz et al 2012) and therefore dietary strategies could be used to influence the epigenetic regulation of this gene and enhance capture of valuable phenotypes Behaviour Glucocorticoid receptor (GR-A) also known as nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1)…”

Section: Final Remarksmentioning

confidence: 99%

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Comparative epigenetics: relevance to the regulation of production and health traits in cattle

2014

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With the development of genomic, transcriptomic and bioinformatic tools, recent advances in molecular technologies have significantly impacted bovine bioscience research and are revolutionising animal selection and breeding. Integration of epigenetic information represents yet another challenging molecular frontier. Epigenetics is the study of biochemical modifications to DNA and to histones, the proteins that provide stability to DNA. These epigenetic changes are induced by environmental stimuli; they alter gene expression and are potentially heritable. Epigenetics research holds the key to understanding how environmental factors contribute to phenotypic variation in traits of economic importance in cattle including development, nutrition, behaviour and health. In this review, we discuss the potential applications of epigenetics in bovine research, using breakthroughs in human and murine research to signpost the way.

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Section: Epigenetics and Nutritionmentioning

confidence: 93%

Section: Final Remarksmentioning

confidence: 99%

Comparative epigenetics: relevance to the regulation of production and health traits in cattle

2014

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“…whether the allele is derived from the maternal or paternal line). The insulin-like growth factor 2 gene (IGF2) encodes an essential growth factor which is associated with both beef and milk production traits in cattle (Goodall and Schmutz, 2007;Flisikowski et al, 2007;Bagnicka et al, 2010). This gene is imprinted in a tissue specific manner (Gebert et al, 2006), indicating that epigenetic processes regulate the capture of these traits in any animal.…”

Section: Challenges and Future Researchmentioning

confidence: 99%

The integration of ‘omic’ disciplines and systems biology in cattle breeding

Berry

Meade

Mullen

et al. 2011

Animal

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Enormous progress has been made in the selection of animals, including cattle, for specific traits using traditional quantitative genetics approaches. Nevertheless, considerable variation in phenotypes remains unexplained, and therefore represents potential additional gain for animal production. In addition, the paradigm shift in new disciplines now being applied to animal breeding represents a powerful opportunity to prise open the 'black box' underlying the response to selection and fully understand the genetic architecture controlling the traits of interest. A move away from traditional approaches of animal breeding toward systems approaches using integrative analysis of data from the 'omic' disciplines represents a multitude of exciting opportunities for animal breeding going forward as well as providing alternatives for overcoming some of the limitations of traditional approaches such as the expressed phenotype being an imperfect predictor of the individual's true genetic merit, or the phenotype being only expressed in one gender or late in the lifetime of an animal. This review aims to discuss these opportunities from the perspective of their potential application and contribution to cattle breeding. Harnessing the potential of this paradigm shift also poses some new challenges for animal scientists -and they will also be discussed.

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“…Insulin-like growth factor 2 (IGF2) and insulin (INS) are localized within the milk production QTL on the chromosome 29 in cattle, and several studies have showed a statistical association between IGF2 polymorphisms and milk production traits [1][2][3][4]. Pivotal role in the control of milk synthesis plays somatotropic axis with its major component-the growth hormone (GH) which acts via IGF to increase milk synthesis in the mammary gland.…”

Section: Introductionmentioning

confidence: 99%

Hypermethylation of INS Promoter in the Developing Liver of Cattle

2013

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Insulin (INS) and insulin-like growth factor 2 (IGF2) are both important for the milk synthesis in human and dairy cattle. Liver is a source of growth factors that play an important role in the regulation of milk synthesis in the mammary gland in influence its composition. Occurrence of common INS-IGF transcript and imprinting regulation in some human tissues suggests close interaction between both genes. Here, we analyzed the DNA methylation pattern of the INS promoter and IGF2 expression at six different pre-and postnatal developmental stages of bovine liver. We found stage-independent DNA hypermethylation (93%) of the INS promoter. In contrast, we observed a 4-fold decrease of the IGF2 expression in 12-month-old adult animals compared to 2-month-old fetuses. We therefore suggest that DNA methylation at the INS promoter does not directly regulate the IGF2 expression in the bovine liver.

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An InDel Polymorphism in Exon 6 of IGF2 Associated with the Breeding Value of Polish Holstein-Friesian Bulls

Cited by 11 publications

References 22 publications

Comparative epigenetics: relevance to the regulation of production and health traits in cattle

Comparative epigenetics: relevance to the regulation of production and health traits in cattle

The integration of ‘omic’ disciplines and systems biology in cattle breeding

Hypermethylation of INS Promoter in the Developing Liver of Cattle

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