An independent effect of parental lipids on the offspring lipid levels in a cohort of adolescents with type 1 diabetes

Abstract

In the present study, parental lipid levels were independently associated with the same traits in the offspring, suggesting a role of genetic influences and/or shared environmental factors in modulating the metabolic profile of adolescents with T1D. In contrast, there was no significant association between parental lipid levels and the offspring's albumin excretion.

Clustering of cardio-metabolic risk factors in parents of adolescents with type 1 diabetes and microalbuminuria

“…A similar association between parental history of hypertension and MA in the offspring was reported in other 2 previous studies . In contrast, we were not able to show any effect of parental lipid levels on the risk of MA in the offspring …”

“…Previous family studies in adults with T1D have reported an association between parental CVD risk factors, such as hypertension, insulin resistance and type 2 diabetes, as well as their clustering, and presence of nephropathy in the offspring . Limited data are available for young people with childhood‐onset T1D . In 2 previous studies, we showed an independent effect of parental blood pressure, assessed by 24‐hour ambulatory blood pressure monitoring, on urinary albumin excretion in young offspring with T1D .…”

“…18,19 In contrast, we were not able to show any effect of parental lipid levels on the risk of MA in the offspring. 20 The aim of this study was to investigate the association between an aggregation of cardio-metabolic risk factors in parents of young people with T1D and the occurrence of MA during adolescence in the offspring.…”

Maternal Phytosterol Supplementation during Pregnancy and Lactation Modulates Lipid and Lipoprotein Response in Offspring of apoE-Deficient Mice

“…Both animal (11,12) and human studies (13,14) have demonstrated the influential effect of maternal hyperlipidemia during pregnancy on lipid concentrations in offspring. Furthermore, cholesterol concentrations in newborns have been shown to be predictive of cardiovascular disease (CVD) 6 risk in adulthood (15)(16)(17).…”

Malprogramming of Hepatic Lipid Metabolism due to Excessive Early Cholesterol Exposure in Adult Progeny

“…Furthermore, although there is a normal physiological increase in maternal cholesterol (+25–50%) during pregnancy which is vital for embryogenesis and early organ development, an excessive increase in maternal serum cholesterol can manifest during pregnancy, particularly in women with elevated cholesterol prior to conception . Such an exaggerated rise in early cholesterol exposure has been associated with pre‐term delivery and low birth weight, increased childhood body mass index and adiposity, increased blood lipids in the neonatal, adolescent, and adult periods, and fetal fatty streaks that develop faster in childhood . It has been estimated that 10–25% of US women of childbearing years are hypercholesterolemic, having blood total cholesterol (TC) concentrations >240 mg dL −1 .…”