An Indicator for Evaluating the Risk of Cancerous Transformations of Human Induced Pluripotent Stem Cells

Abstract

copper alone, but with a large amount of copper incorporated into the not entirely characterized lysosomal complex of metallothionein polymers with a glycoprotein component, as supported by periodic acid-Schiff staining. We realized that copper-metallothionein autofluorescence was well-known in earlier literature, and wondered about its possible practical use and the potential role of autofluorescence in liver pathology as quoted in an excellent review on the subject. 2 We thought it was worth sharing this matter in the Image of the Month forum and remain glad to have generated some academic debate. ALBERTO

The generation of human induced pluripotent stem (iPS) cells from liver progenitor cells by only small molecules and the risk for malignant transformations of the cells

“…Moreover, though we previously found the induction of p21 was necessary to avoid malignant transformations of human iPS cells (8), the result was also true of the case of ChiPS cells in the present study.…”

Generation of Human Induced Pluripotent Stem (iPS) Cells from Liver Progenitor Cells by Two Chemicals and the Clinical Application

“…Therefore, the efficiency was improved more than previous reports (3) (5) (6) (7). Moreover, though we previously found the induction of p21 was necessary to avoid malignant transformations of human iPS cells (8), the result was also true of the case of ChiPS cells in the present study.…”