An individual differences analysis of the neurocognitive architecture of the semantic system at rest

Mollo, Giovanna; Karapanagiotidis, Theodoros; Bernhardt, Boris C.; Murphy, Charlotte; Smallwood, Jonathan; Jefferies, Elizabeth

doi:10.1016/j.bandc.2016.07.003

Cited by 16 publications

(13 citation statements)

References 92 publications

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“…Enhanced activity of frontal regions is associated with language comprehension and semantic knowledge, i.e. controlled retrieval of semantic information ( Devlin et al, 2003 , Gough, 2005 , Mollo et al, 2016 ). Activation in the dorsal ACC observed in healthy controls may be considered to be the executive center of the error detection and conflict monitoring system ( Gauvin et al, 2016 , Swick and Turken, 2002 ).…”

Section: Discussionmentioning

confidence: 99%

Neural circuit of verbal humor comprehension in schizophrenia - an fMRI study

Adamczyk

Wyczesany

Domagalik

et al. 2017

NeuroImage: Clinical

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Individuals with schizophrenia exhibit problems with understanding the figurative meaning of language. This study evaluates neural correlates of diminished humor comprehension observed in schizophrenia. The study included chronic schizophrenia (SCH) outpatients (n = 20), and sex, age and education level matched healthy controls (n = 20). The fMRI punchline based humor comprehension task consisted of 60 stories of which 20 had funny, 20 nonsensical and 20 neutral (not funny) punchlines. After the punchlines were presented, the participants were asked to indicate whether the story was comprehensible and how funny it was. Three contrasts were analyzed in both groups reflecting stages of humor processing: abstract vs neutral stories - incongruity detection; funny vs abstract - incongruity resolution and elaboration; and funny vs neutral – complete humor processing. Additionally, parametric modulation analysis was performed using both subjective ratings separately. Between-group comparisons revealed that the SCH subjects had attenuated activation in the right posterior superior temporal gyrus (BA 41) in case of irresolvable incongruity processing of nonsensical puns; in the left dorsomedial middle and superior frontal gyri (BA 8/9) in case of incongruity resolution and elaboration processing of funny puns; and in the interhemispheric dorsal anterior cingulate cortex (BA 24) in case of complete processing of funny puns. Additionally, during comprehensibility ratings the SCH group showed a suppressed activity in the left dorsomedial middle and superior frontal gyri (BA 8/9) and revealed weaker activation during funniness ratings in the left dorsal anterior cingulate cortex (BA 24). Interestingly, these differences in the SCH group were accompanied behaviorally by a protraction of time in both types of rating responses and by indicating funny punchlines less comprehensible. Summarizing, our results indicate neural substrates of humor comprehension processing impairments in schizophrenia, which is accompanied by fronto-temporal hypoactivation.

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Section: Discussionmentioning

confidence: 99%

Neural circuit of verbal humor comprehension in schizophrenia - an fMRI study

Adamczyk

Wyczesany

Domagalik

et al. 2017

NeuroImage: Clinical

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“…A potential motor involvement could thus more confidently be attributed to emotion-specific processes rather than to task-related motor demands, as the task is conducted offline. The degree of covariance in spontaneous fluctuations of the BOLD signal, measured as the strength of intrinsic connectivity between two or more brain regions, has been shown to be associated with behavioural outcomes in adults and children (e.g., Angelides et al, 2017;Koyama et al, 2011;Mollo et al, 2016;Supekar et al, 2013), but no studies so far have examined emotional prosody. Using a hypothesis-driven seed-based correlational approach, we hypothesized that a stronger intrinsic connectivity between the motor system (target) and regions established to play a role for vocal emotional processing -AC, STC and IFG (seeds) -relates to a better ability to recognize prosodic emotions.…”

Section: A N U S C R I P Tmentioning

confidence: 99%

Resting-state connectivity reveals a role for sensorimotor systems in vocal emotional processing in children

et al. 2019

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Voices are a primary source of emotional information in everyday interactions. Being able to process non-verbal vocal emotional cues, namely those embedded in speech prosody, impacts on our behavior and communication. Extant research has delineated the role of temporal and inferior frontal brain regions for vocal emotional processing. A growing number of studies also suggest the involvement of the motor system, but little is known about such potential involvement. Using resting-state fMRI, we ask if the patterns of motor system intrinsic connectivity play a role in emotional prosody recognition in children. Fifty-five 8-year-old children completed an emotional prosody recognition task and a resting-state scan. Better performance in emotion recognition was predicted by a stronger connectivity between the inferior frontal gyrus (IFG) and motor regions including primary motor, lateral premotor and supplementary motor sites. This is mostly driven by the IFG pars triangularis and cannot be explained by differences in domain-general cognitive abilities. These findings indicate that individual differences in the engagement of sensorimotor systems, and in its coupling with inferior frontal regions, underpin variation in children's emotional speech perception skills. They suggest that sensorimotor and higher-order evaluative processes interact to aid emotion recognition, and have implications for models of vocal emotional communication.

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“…specific-level concepts). Studies show that individual differences between participants in the strength of intrinsic connectivity, defined according to time-series correlations in resting-state fMRI, are associated with variation in cognitive performance (Cole et al, 2014;Smith et al, 2009;Van Dijk et al, 2010), including semantic cognition (Evans et al, 2020;Gonzalez Alam et al, 2018;Mollo et al, 2016;Poerio et al, 2017;Vatansever et al, 2017;Zhang et al, 2019). Hemispheric differences in intrinsic connectivity across individuals have already been linked to semantic and spatial tasks (Gonzalez Alam et al, 2019;Sormaz et al, 2017; although these prior studies did not find associations with ATL connectivity).…”

Section: Introductionmentioning

confidence: 99%

“…Hemispheric differences in intrinsic connectivity across individuals have already been linked to semantic and spatial tasks (Gonzalez Alam et al, 2019;Sormaz et al, 2017; although these prior studies did not find associations with ATL connectivity). Individual differences in the connectivity of ATL have also been associated with semantic processing, although these studies did not examine hemispheric differences (Mollo et al, 2016;Vatansever et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Intrinsic connectivity of anterior temporal lobe relates to individual differences in semantic retrieval for landmarks

Alam

Krieger-Redwood

Evans

et al. 2021

Cortex

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An individual differences analysis of the neurocognitive architecture of the semantic system at rest

Abstract: HighlightsVariations in semantic performance are reflected in resting-state networks.Inferior frontal connectivity predicts verbal fluency performance.Connectivity between visual and anterior temporal areas predicts synonym judgement.

Cited by 16 publications

References 92 publications

Neural circuit of verbal humor comprehension in schizophrenia - an fMRI study

Neural circuit of verbal humor comprehension in schizophrenia - an fMRI study

Resting-state connectivity reveals a role for sensorimotor systems in vocal emotional processing in children

Intrinsic connectivity of anterior temporal lobe relates to individual differences in semantic retrieval for landmarks

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