An indolizine–rhodamine based FRET fluorescence sensor for highly sensitive and selective detection of Hg²⁺ in living cells

Abstract

An indolizine–rhodamine-based ratiometric fluorescent probe was designed and successfully synthesized.

Microwave-Assisted Synthesis of Fluorescent Pyrido[2,3-b]indolizines from Alkylpyridinium Salts and Enaminones

“…Indolizines, and in particular the annulated ones, are frequently found to exhibit useful biological [ 1 , 2 , 3 , 4 , 5 , 6 ] and optical properties [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. The synthesis of indolizines usually relies on the reactivity of pyridinium ylides, which can undergo cycloaddition reactions with alkenes [ 15 , 16 , 17 , 18 ] or alkynes [ 19 , 20 , 21 , 22 , 23 ].…”

Highly Fluorescent Pyrido[2,3‐b]indolizine‐10‐Carbonitriles through Pseudo Three‐Component Reactions of N‐(Cyanomethyl)pyridinium Salts

“…Domino and multicomponent reactions allow rapid and efficient construction of molecular complexity; they are widely used for the synthesis of natural products and analogues,, pharmaceutical substances, functional materials,, macrocyclizations, Employing these tools for the preparation of fluorophores and electrophores emerged as a useful technique, enabling fast creation of numerous scaffolds with diverse structure and needful properties. Indolizines are indeed sought‐for heterocycles,, which have various applications as biologically active compounds, dyes, molecular probes and sensors . They are also well‐known fluorophores, with some recent examples of multicomponent syntheses .…”

Deciphering of Ligand‐to‐Metal Charge‐Transfer Process: Synthesis, Spectroscopic and Theoretical Study

“…Recognition of transition metal ions has evolved as an important area of interdisciplinary research topic in biological, industrial and environmental fields because of fast and highly sensitive detection ability of synthesized ligand over other conventional techniques . A wide range of articles on Cu 2+ or any other metal ion sensing field was benchmarked against lower limit of detection values but there is no report on the reason for selecting a particular metal ion sensing among a series of metal ions . Here we have drawn attention to the reason of selecting a particular metal ion among a series of metal ions.…”

“…In this perspective, fluorescence technique is one of the most promising among various analytical tools. Because of its ease and high sensitivity, fluorescence is also essential to trace the recognition of different analytes ,. In recent times, research work is being carried out on synthesizing fluorescent probes for Cu 2+ detection .…”