An induction heating device using planar coil with high amplitude alternating magnetic fields for magnetic hyperthermia

Abstract

Abstract. BACKGROUND: Induction heating devices using the induction coil and magnetic nanoparticles (MNPs) are the way that the magnetic hyperthermia is heading. OBJECTIVE: To facilitate the induction heating of in vivo magnetic nanoparticles in hyperthermia experiments on large animals. METHODS: An induction heating device using a planar coil was designed with a magnetic field frequency of 328 kHz. The coil's magnetic field distribution and the device's induction heating performance on different concentrations of magnetic nanoparticles were measured. RESULTS: The alternating magnetic field produced in the axis position 165 mm away from the coil center is 40 Gs in amplitude; magnetic nanoparticles with a concentration higher than 80 mg. mL −1 can be heated up rapidly. CONCLUSION: Our results demonstrate that the device can be applied not only to in vitro and in small animal experiments of magnetic hyperthermia using MNPs, but also in large animal experiments.

Study of the Dependency of the Specific Power Absorption Rate on Several Characteristics of the Excitation Magnetic Signal when Irradiating a SPION-containing Ferrofluid

“…Hyperthermia is a very commonly used technique in cancer treatment [1,2] for its primary therapeutic effects and because it can help the release and even activation of some anticancer drugs. When cancer cells are heated at a temperature ranging from 42 to 45°C, for a period of time of at least 30 minutes [3][4][5][6][7], they die due to the suffered hyperthermia.…”

“…Brownian relaxation is characterized by the parameter τ B (s) whilst Néel relaxation is characterized by τ N (s). When particles are suspended in water, both processes are combined to produce the net relaxation time (τ R ) as follows: (1) In the case of superparamagnetic particles, τ R is determined by τ N . [12,13,14].…”

Magnetic Active Water Filter Membrane for Induced Heating to Remove Biofoulants

“…Using a weaker AMF is also possible to induce heating on MNPs. For example, a recent report has demonstrated a home-built induction heater with an AMF of 40 G and 328 kHz capable of heating up a small volume of 10 nm MNPs suspended in water with a heating rate of ∼0.065 °C/s . Furthermore, the reported device has a compact design to perform a hyperthermia experiment on mid-size cattle specimens.…”

Nanopartículas de magnetita dopadas com zinco para fins teranósticos: magnetoacustografia e hipertermia magnética

“…In order to have a better idea of the magnetic field in this coil, in addition to the on-axis field (figure 4.5(c)), its whole center volume was scanned using the pickup coil and the results are shown in figure 4.5(d). Although solenoid coils are one of the most common formats to produce the field in magnetic hyperthermia studies [235], this format, due to its physical properties has a limitation to provide adequate space for in vivo or phantom experiments. Increasing the diameter of the coil not only changes its inductance significantly, but it also decreases the field amplitude providing that the same current can pass through the coil.…”

“…Moreover, approaching the animal or gel phantoms for temperature measurement can also be another challenge with this kind of coils. Therefore, other coil formats such as pancake coil has always been considered as an alternative for solenoid coils [235][236][237]. The P coil designed in this study, at resonant frequency of 105 kHz generated a relatively high magnetic field (∼ 16.4 kA/m) at the center of the parallel plane 1 millimeter from its surface.…”