2009
DOI: 10.2353/ajpath.2009.090082
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An Induction in Hepatic HDL Secretion Associated with Reduced ATPase Expression

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Cited by 9 publications
(11 citation statements)
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“…F 1 -ATPase is inhibited by mitochondrial inhibitory factor 1 (IF1) [34] and serum IF1 levels have been shown to be positively correlated with HDL-cholesterol levels and negatively correlated with serum triglyceride levels in normolipidemic subjects [39]. This is consistent with other work, which suggested that therapeutic modulation of circulating HDL levels may be associated with the expression of F 1 -ATPase, ADP production and purinergic signaling [19,40,41]. …”
Section: Nucleotides and Diseasesupporting
confidence: 80%
See 1 more Smart Citation
“…F 1 -ATPase is inhibited by mitochondrial inhibitory factor 1 (IF1) [34] and serum IF1 levels have been shown to be positively correlated with HDL-cholesterol levels and negatively correlated with serum triglyceride levels in normolipidemic subjects [39]. This is consistent with other work, which suggested that therapeutic modulation of circulating HDL levels may be associated with the expression of F 1 -ATPase, ADP production and purinergic signaling [19,40,41]. …”
Section: Nucleotides and Diseasesupporting
confidence: 80%
“…Niacin reduces cell surface levels of F 1 -ATPase in hepatocytes and thereby blocks the production of extracellular ADP [40]. Linoleic acid phospholipids also block ADP production by inhibiting the cell surface expression of F 1 -ATPase and thereby stimulate HDL secretion from liver cells [41]. These phospholipids appear to mute purinergic signaling and cellular autophagy by stimulating Akt phosphorylation and blocking MAPK activation [19].…”
Section: Resultsmentioning
confidence: 99%
“…As in the circulation, HL in hepatocyte medium is primarily associated with larger HDL complexes containing both ApoA-I and ApoA-II. Phospholipid treatment increases the secretion of both ApoA-I and ApoA-II 43,45 and, as shown by Boucher et al, 31 the association of HL with ApoA-II-enriched HDL directly inhibits HL hydrolytic activity.…”
Section: Regulation Of Hl Secretion From the Livermentioning
confidence: 82%
“…43 Instead, PLs stimulate PPAR␣ expression 44 and inhibit membrane nucleotide signaling events on the cell surface to block retroendocytic degradative pathways. 45 The data suggest that PLs block membrane recycling pathways that promote the reuptake and degradation of cell surface proteins such as HL (Figure 2). Hepatic lipase degradation has been shown to be rate-limiting to HL secretion, and associated with the dimerization of the enzyme.…”
Section: Regulation Of Hl Secretion From the Livermentioning
confidence: 99%
“…Similarly, niacin appears to regulate the recycling/reuptake of newly secreted apo A-I (Pandey et al, 2009) through the effects of a novel G-protein coupled receptor, P2Y13. This pathway may be central to the HDL raising effects of niacin (Jacquet et al, 2005;Zhang et al, 2008).…”
Section: Introductionmentioning
confidence: 97%