An Inexpensive Protocol for Biginelli Reaction.

Abstract

A one-pot synthesis of the pyrimidine derivatives (IV) catalyzed by a cupric chloride-lithium chloride combination catalyst is reported as a simple and elegant protocol for the title reaction. -(MANJULA, A.; RAO*, B. V.; NEELAKANTAN, P.; Synth.

Synthesis of Novel Oxo Pyrimido Pyrimidine and Their Derivatives

“…In the view of this observation and extension of earlier work, we have synthesized 2-(4-methoxyphenyl)-8-(methylthio)-6-oxo-4phenyl-1,6,9,9a-tetrahydro-2H-pyrimido[1,2-a] pyrimidine-7-carbonitrile (3) by using6-(4-methoxyphenyl)-4-phenyl-1,6dihydropyrimidin-2-amine (2)[27][28] and ethyl 2-cyano-3, 3-bis(methylthio)acrylate. 6-(4-methoxyphenyl)-4-phenyl-1,6dihydropyrimidin-2-amine (2) is prepared by the reaction of 3-(4-methoxyphenyl)-1-phenyl prop-2-en-1-one (1)chalcone[29][30] with guanidine nitrate in the presence of alcoholic potassium hydroxide under reflux condition.II.METHODS Melting points were determined in open capillary tubes and are uncorrected.…”

Synthesis and comparing the antibacterial activities of pyrimidine derivatives

“…All additional information pertaining to characterization of the compounds using FT-IR spectra (Figures S1 to S10 and S31 to S40), 1 H NMR spectra (Figures S11 to S20 and S41 to S50), 13 C NMR spectra ( Figures S21 to S30 and S51 to S60), antibacterial screening data (Tables S1, S2) and antibacterial activities comparative diagram ( Figure S1, S2 and S3) are given in the supporting information available at www.ias.ac. in/chemsci.…”

Untitled

“…p-toluenesulfonic acid 7 , potassium hydrogen sulphate 8 , chloroacetic acid 9 , titanium(IV)chloride 10 , ruthenium(III)chloride 11 , scandium(III)triflate 12 ,Iodine-alumina 13 ,Cobalt(II) acetate 14 , sulphated zirconia 15 , ferric chloride hexahydrate 16 , MgBr 2 17 , nbcl 5 18 , Lewis acids 19,20 viz. Yb (OTf) 3 21 , InCl 3 22 , CuCl 2 23 , SnCl 2 24 , BF 3 .OEt 2 25 , ZrCl 4 26 , L-proline 19 , L-proline methylester hydrochloride 27 , ZnCl 2 28, 29 , Zinc sulphamate 30 , combination catalytic system such as tin chloride-lithium chloride 31 , cupric chloridelithium chloride 32 , ferric chloride/tetraethyl orthosilicates 33 , Trimethylsilyl triflate 34 , strontium(II)triflate 35 , cadmium chloride 36 , methanesulfonic acid 37 , Iron(III) 38 , (AlCl 3 +KI) 39 , bimetal system , Cupy 2 Cl 2 40 , Samariumdiiodide 41 . Besides these catalysts, recently Pb(NO 3 ) 3, 42 , alkaline phosphates 43,44,45 and sulphates 46 have been also employed.…”