An Infant with Chediak-Higashi Syndrome and Lymphoma

Yamak, Behice; Hiçsönmez, G; Özsoylu, Şînasi; Imamoglu, Ilhan

doi:10.1177/000992287201100510

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Discussion1

Figures 2 and 3 Somatic Manifestations Of Patient1

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1993

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Cited by 7 publications

(2 citation statements)

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“…Previous reports have implied that CHS patients develop malignant lymphoma [15,23,24] or lymphoma-like [25,26] diseases in their terminal stages. The mononuclear infiltrates in the CHS children have been described as peculiar or atypical lymphoma [27].…”

Section: Discussionmentioning

confidence: 99%

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Chediak-Higashi Syndrome: Report on Five Saudi Arab Children and Review of the Literature

et al. 1993

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Section: Discussionmentioning

confidence: 99%

“…Patients with CHS have a tendency to develop a lymphoma-like accelerated phase. Yamak et al [23] described an infant with CHS in whom malignant lymphoma developed during infancy. Tan et al [24] described Hodgkin disease in an eight-year-and-nine-month-old female with CHS.…”

Section: Figures 2 and 3 Somatic Manifestations Of Patientmentioning

confidence: 99%

Chediak-Higashi Syndrome: Report on Five Saudi Arab Children and Review of the Literature

et al. 1993

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The accelerated phase of Chediak-Higashi syndrome. An expression of the virus-associated hemophagocytic syndrome?

Rubin

Burke

McKenna

et al. 1985

Cancer

109

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The clinical and pathologic findings of four patients with Chediak-Higashi syndrome in the accelerated phase were studied in order to clarify the nature of this enigmatic process. Fever, lymphadenopathy, hepatosplenomegaly, and cytopenias were present in every patient. All cases demonstrated extensive parenchymal infiltrates in many organs composed of benign-appearing histiocytes manifesting hemophagocytosis accompanied by lymphocytes and plasma cells. Studies in one patient suggested a viral etiology with the findings of a low blood lymphocyte OKT4 to OKT8 ratio, acquired loss of lymphocyte response to mitogens, the presence of Epstein-Barr virus genome in the mononuclear cells of lymph node, blood, and bone marrow, and possible clinical responses to acyclovir. It is concluded that the accelerated phase of Chediak-Higashi syndrome may be the clinicopathologic expression of the virus-associated hemophagocytic syndrome.

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Das Chédiak-Higashi-Syndrom

Belohradsky¹,

Laminger²

1992

Ergebnisse Der Inneren Medizin Und Kinderheilkunde/Advances in Internal Medicine and Pediatrics

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An Infant with Chediak-Higashi Syndrome and Lymphoma

Cited by 7 publications

References 7 publications

Chediak-Higashi Syndrome: Report on Five Saudi Arab Children and Review of the Literature

Chediak-Higashi Syndrome: Report on Five Saudi Arab Children and Review of the Literature

The accelerated phase of Chediak-Higashi syndrome. An expression of the virus-associated hemophagocytic syndrome?

Das Chédiak-Higashi-Syndrom

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