An inflammatory profile linked to increased suicide risk

Keaton, Sarah A.; Madaj, Zachary; Heilman, Patrick L.; Smart, LeAnn; Grit, Jamie; Gibbons, Robert D.; Postolache, Teodor T.; Roaten, Kimberly; Achtyes, Eric D.; Brundin, Lena

doi:10.1016/j.jad.2018.12.100

Cited by 78 publications

(66 citation statements)

References 70 publications

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“…Relevantly, the genetic overlap between IL-8 and risk for suicide attempts was significant in females but not males. According to Keaton et al [34], the biological profile of patients considered to be at increased risk of suicide differed from that of depressed individuals. Importantly, blood cell count and polymorphonuclear leukocyte count had a significant impact on suicide risk.…”

Section: Studies Analyzing Inflammatory Abnormalities In Suicidal Patmentioning

confidence: 99%

“…However, based on the selected studies and in line with a previously published paper of our research group upon the same topic [7], the existence of an association between inflammatory cytokines abnormalities and suicidal behavior does not necessarily reflect a specific causal link. Among the selected studies, eleven reports [8,9,12,[25][26][27][28][29][30][31][32] analyzed inflammatory cytokines abnormalities in suicidal patients, four [33][34][35][36] explored cytokines abnormalities in patients with both a positive history of suicide attempts and suicidal ideation, two [37,38] investigated the existence of inflammatory cytokines abnormalities levels in depressed patients with suicidal ideation vs. those abnormally without, seven [31,[40][41][42][43][44]50] examined the inflammatory cytokines abnormalities in patients with a history of suicide attempts vs. those without, three [45][46][47] analyzed patients died by suicide vs. those died for other causes, and two [48,49] focused on depressed suicidal patients with suicidality.…”

Section: Summary Of Main Findings and Review Of Study Designsmentioning

confidence: 99%

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A Specific Inflammatory Profile Underlying Suicide Risk? Systematic Review of the Main Literature Findings

Serafini

Parisi

Aguglia

et al. 2020

IJERPH

135

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Consistent evidence indicates the association between inflammatory markers and suicidal behavior. The burden related to immunological differences have been widely documented in both major affective disorders and suicidal behavior. Importantly, abnormally elevated pro-inflammatory cytokines levels have been reported to correlate with suicidal behavior but whether and to what extent specific inflammatory cytokines abnormalities may contribute to our understanding of the complex pathophysiology of suicide is unknown. The present manuscript aimed to systematically review the current literature about the role of pro-inflammatory cytokines in suicidal behavior. Most studies showed a link between abnormally higher interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β1, vascular endothelial growth factor (VEGF), kynurenic acid (KYN), and lower IL-2, IL-4, and interferon (IFN)-γ levels in specific brain regions and suicidal behavior. Unfortunately, most studies are not able to exclude the exact contribution of major depressive disorder (MDD) as a mediator/moderator of the link between inflammatory cytokines abnormalities and suicidal behavior. The association between suicidal patients (both suicide attempters or those with suicidal ideation) and the altered immune system was documented by most studies, but this does not reflect the existence of a specific causal link. Additional studies are needed to clarify the immune pathways underlying suicidal behavior.

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Section: Studies Analyzing Inflammatory Abnormalities In Suicidal Patmentioning

confidence: 99%

Section: Summary Of Main Findings and Review Of Study Designsmentioning

confidence: 99%

A Specific Inflammatory Profile Underlying Suicide Risk? Systematic Review of the Main Literature Findings

Serafini

Parisi

Aguglia

et al. 2020

IJERPH

135

View full text Add to dashboard Cite

show abstract

“…Previous studies have suggested an association between inflammation and increased suicide risk in people with a psychiatric illness [36], but whether the association between CMV infection and suicide exists is uncertain. Previous research in this area has found increased levels of inflammatory markers (e.g., interleukin-6) in patients with suicidal ideation and behaviour [37,38].…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus Seropositivity and Suicidal Behavior: A Mini-Review

et al. 2019

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Background and objectives: In recent years, a growing body of research has focused on identifying possible biological markers for suicidal behavior, including infective and immunological markers. In this paper, our aim was to review available evidence concerning the association between cytomegalovirus (CMV) infection and suicide. Materials and Methods: A systematic search according to the PRISMA statement was performed on Pubmed. After the screening procedure, we identified five relevant papers. Results: We found inconsistent evidence linking CMV infection and suicide, with some papers reporting an association between CMV seropositivity and suicidal behavior, and others not finding the association. Conclusions: With the evidence available presently, it is not possible to infer whether there is a correlation between suicide and CMV infection.

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“…Elevated pro-inflammatory cytokines have been found in blood and cerebrospinal fluid and postmortem brain samples from suicidal patients, 25 indicating that inflammation may contribute to the pathophysiology of suicide. 28,29 Several studies reviewed for this article show the existence of a high prevalence of lifetime suicidal ideation, suicidal behavior, attempted, and completed suicide in patients with psoriasis in comparison with not only normal subjects but with subjects suffering from other dermatological conditions as well. [30][31][32] As the association between psoriasis and psychiatric comorbidity, including suicide and risk of self-harm, has been vastly reported in the literature, a right and early psoriasis treatment improves the mental condition, particularly depression and anxiety.…”

Section: Psoriasis and Depressionmentioning

confidence: 98%

Could Suicide Be Fostered Through the Potential Antidepressant Mechanism of Biological Agents? A Psychodermatological Approach to Existing Bibliography

Malatesta¹,

Río²

2020

Journal of Psoriasis and Psoriatic Arthritis

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Background: Bipolar disorder (BD) is a biological condition that affects between 2% and 5% of the population. Despite this, it is often underdiagnosed as unipolar depression, which increases the possibility of prescribing errors. This could foster episodes of inverse polarity (“switching”) which, in turn, raises the risk of suicide. Objective: This work reviews the existing literature for evidence that while biological agents could improve the mood of patients with psoriasis treated with these drugs, this same favorable antidepressant effect on humor may trigger a switch into mania, favoring attempted and completed suicide in undiagnosed bipolar patients treated for psoriasis with the abovementioned agents. Method: A systematic review of the literature was performed for evidence. Based on their titles and abstracts, 48 relevant articles from 18 countries in English, Spanish, and French from 2004 to 2019 were selected for this review. Results: Inherently, all antidepressants can be associated with treatment-emergent affective switch (TEAS). Biological agents may modify the neurotransmitter levels either improving or worsening the mood. A plausible hypothesis arises on the double-edged nature of biological agents: they would have an antidepressant effect that would be beneficial to treat the psychiatric comorbidity of the patient with psoriasis. However, this same antidepressant effect, in a patient with genetic vulnerability for depression with a concomitant inflammatory disease, could trigger a mood alteration. Conclusion: Both BD and psoriasis should be considered as a multisystem entity with a common physiopathology. Consequently, it is vital to emphasize the importance of the initial psychiatric evaluation.

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An inflammatory profile linked to increased suicide risk

Cited by 78 publications

References 70 publications

A Specific Inflammatory Profile Underlying Suicide Risk? Systematic Review of the Main Literature Findings

A Specific Inflammatory Profile Underlying Suicide Risk? Systematic Review of the Main Literature Findings

Cytomegalovirus Seropositivity and Suicidal Behavior: A Mini-Review

Could Suicide Be Fostered Through the Potential Antidepressant Mechanism of Biological Agents? A Psychodermatological Approach to Existing Bibliography

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