An inhibitor of the production of interferon (“blocker”)

Isaacs, A.; Rotem, Z.; Fantes, K. H.

doi:10.1016/0042-6822(66)90031-6

Cited by 35 publications

(16 citation statements)

References 10 publications

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“…A conspicuous difference from enhancer ,blocker or depressor is that stimulon is sensitive to trypsin. Furthermore, stimulon is inactivated by viral antiserum, a property quite distinct from that of enhancer, blocker or depressor [24]. This would suggest that stimulon might be encoded in the viral genome.…”

Section: Anti-interferon Effects Of Helper Virus In End Phenomenonmentioning

confidence: 99%

“…This finding suggests that depressor and enhancer are one and the same factor which enhances viral replication by suppression of interferon production. However, it appears difficult for the hypothesis to explain the fact that the antiviral activity of exogenous interferon is negated by enhancer [24,44].…”

Section: Anti-interferon Effects Of Helper Virus In End Phenomenonmentioning

confidence: 99%

“…These properties are similar to those of depressor and blocker. Isaacs and associates [24], however, cited some differences between enhancer and blocker. Firstly, blocker did not show significant enhancement of virus growth in the chick chorioallantoic membrane.…”

Section: Anti-interferon Effects Of Helper Virus In End Phenomenonmentioning

confidence: 99%

“…Studies by Isaacs, Rotem and Fantes [24] and by Ohta [43] provide information of primary importance. Isaacs and associates [24] found some preparations of crude interferon which inhibited interferon production as well as virus growth. This inhibition of interferon production was shown to be due to an inhibitor for which the name "blocker" was proposed (Table 10).…”

Section: Anti-interferon Effects Of Helper Virus In End Phenomenonmentioning

confidence: 99%

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Enhanced Replication of Newcastle Disease Virus in Cell Culture Co-infected with Certain Other Viruses

Matumoto

1968

Japanese Journal of Microbiology

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Section: Anti-interferon Effects Of Helper Virus In End Phenomenonmentioning

confidence: 99%

Section: Anti-interferon Effects Of Helper Virus In End Phenomenonmentioning

confidence: 99%

Section: Anti-interferon Effects Of Helper Virus In End Phenomenonmentioning

confidence: 99%

Section: Anti-interferon Effects Of Helper Virus In End Phenomenonmentioning

confidence: 99%

See 2 more Smart Citations

Enhanced Replication of Newcastle Disease Virus in Cell Culture Co-infected with Certain Other Viruses

Matumoto

1968

Japanese Journal of Microbiology

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“…Our findings are somewhat reminiscent, perhaps [17], namely inhibition by infective virus of interferon production stimulated by inactivated virus, but the relationship between our findings and the inverse interference is not clear. Inhibitors of interferon production have been found in allantoic fluid of virus-infected eggs ("blocker" [14]; "interferon depressor" [15]). These apparently differ from non-inducer RNA in their action in inhibiting virus-induced interferon production.…”

Section: Rna Acting As An Inducer In One Kindmentioning

confidence: 99%

Antagonism of Non‐Inducer Ribonucleic Acid against Induction of Antiviral Cell Resistance and Interferon by Inducer Ribonucleic Acid

Kawade

Matsuyama

Yamamoto

et al. 1972

Japanese Journal of Microbiology

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Various single-stranded RNAs, which do not induce antiviral cell resistance in L and chick embryo cells, were found to antagonize the action of inducer RNAs such as poly(C)¥poly(I). The non-inducing RNA inhibited production of interferon stimulated by inducer RNA, but did not inhibit the action of exogenously added interferon. Two aspects were discerned in the antagonism of non-inducing RNA, namely intrinsic antagonism and anti-protamine effect. The intrinsic antagonism is the one observed in the absence of protamine. The anti-protamine effect is elimination of the potentiating action of protamine on inducing RNA [10] by non-inducing RNA in a large excess over protamine. The relative importance of the two effects will vary depending on the concentrations of protamine and non-inducing RNA used. Non-inducer RNA added to cells pretreated with inducer RNA for 1-3 hr effectively inhibited the development of antiviral cell resistance, but was not very effective when added prior to inducer RNA. RNA from MS2 phage virions was found to be an inducer in chick embryo cell but a non-inducer and antagonist in human embryo lung fibroblasts, indicating that a given RNA may possess both the inducer and the antagonist characters. The induction of interferon by viruses was not significantly inhibited by non-inducing RNA. The results obtained are consistent with an assumption that non-inducing RNA competitively inhibits the binding of inducer RNA to cellular receptor sites, although alternative interpretations are not excluded.

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Aspirin as a Risk Factor in Reye's Syndrome

Waldman¹

1982

JAMA

183

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An inhibitor of the production of interferon (“blocker”)

Cited by 35 publications

References 10 publications

Enhanced Replication of Newcastle Disease Virus in Cell Culture Co-infected with Certain Other Viruses

Enhanced Replication of Newcastle Disease Virus in Cell Culture Co-infected with Certain Other Viruses

Antagonism of Non‐Inducer Ribonucleic Acid against Induction of Antiviral Cell Resistance and Interferon by Inducer Ribonucleic Acid

Aspirin as a Risk Factor in Reye's Syndrome

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