An injectable drug-loaded hydrogel based on a supramolecular polymeric prodrug

Xiong, Lu; Luo, Qiaojie; Wang, Ying; Li, Xiaodong; Shen, Zhiquan; Zhu, Weipu

doi:10.1039/c5cc06025g

Cited by 81 publications

(55 citation statements)

References 42 publications

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“…Finally,t he drug efficacyw as studied in vivo.A ni njectable drug-loaded hydrogel was described by Zhu and co-workers. [152] Thed rug loading was achieved through the supramolecular interaction of b-CD and adamantyl-functionalized DOX. Jiang and co-workers presented aPVP-b-poly(aspartic acid) diblock copolymer based on b-CD.…”

Section: Angewandte Chemiementioning

confidence: 99%

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

2017

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Dynamic and adaptive materials are powerful constructs in macromolecular and polymer chemistry with a wide array of applications in drug delivery, bioactive systems, and self‐healing materials. Very often, dynamic materials are based on carefully tailored cyclodextrin host–guest interactions. The precise incorporation of these host and guest moieties into macromolecular building blocks allows the formation of complex macromolecular structures with predefined functions. Thus, dynamic materials with extraordinary adaptive property profiles—responsive to thermal, chemical, and photonic fields—become accessible. This Review explores the hierarchical formation of dynamic materials and complex macromolecular structures from the molecular via the macromolecular to the colloidal and macroscopic level, with a specific emphasis on the functionality and responsiveness of the assemblies, specifically in biological contexts.

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Section: Angewandte Chemiementioning

confidence: 99%

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

2017

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“…Dextran (3.00 g) was dissolved in deionized water (100 mL) at 50°C. After cooling to the room temperature, sodium periodate (3.96 g, 18.52 m M ) was added to the solution . The reaction was conducted at 25°C for 2 h. Then ethylene glycol (1.15 g, 18.52 m M ) was added to the solution proceeding for 2 h. The solution was dialyzed against water for 48 h by using a dialysis bag MD44 (MWCO: 8000‐14,000, America) to remove the by‐products and then freeze‐dried (yield: 2.79 g, 93%).…”

Section: Methodsmentioning

confidence: 99%

“…The concentration of aldehyde groups on PAD was determined according to the established procedure described in the literature . In brief, PAD (0.15 g) was dissolved in hydroxylamine hydrochloride solution (25 mL, 0.25 M ), where two drops of methyl orange reagent (0.05%) was added.…”

Section: Methodsmentioning

confidence: 99%

“…In this work, a polysaccharide hydrogel was synthetized via Schiff base reaction between carboxymethyl chitosan (CMCTS) and glucan. In addition, Schiff base itself has antibacterial, sterilization, antitumor, and antiviral bioactive . Water‐insoluble VCZ was loaded through the inclusion into the β‐cyclodextrin (β‐CD) cavity on the linear poly β‐CD chain, which was in situ twined in the cross‐linked structure formed by polyaldehyde dextran (PAD) and CMCTS in the physiological solution .…”

Section: Introductionmentioning

confidence: 99%

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Injectable Schiff base polysaccharide hydrogels for intraocular drug loading and release

Yang

Gao

Liu³

et al. 2019

J Biomedical Materials Res

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A novel voriconazole (VCZ)‐loaded injectable hydrogel was in situ synthetized via a Schiff base reaction between polyaldehyde dextran (PAD) and carboxymethyl chitosan (CMCTS) for intraocular drug loading and release. Water‐insoluble VCZ, which is an effective agent in clinic treating fungal endophthalmitis, was loaded through the inclusion into the β‐cyclodextrin (β‐CD) cavity based on host‐guest interaction on the linear poly β‐CD chain, which was in situ twined in the cross‐linked hydrogel structure. The gelation time, degradation, and drug release process were investigated by studying three kinds of hydrogels with different volume ratio of PAD to CMCTS resolving in phosphate buffered saline (PBS) solution (3:7, 6:7, 9:7), respectively. The property of VCZ‐loaded injectable hydrogel should be adjusted through changing the cross‐linked density of the hydrogel, the molecular weight or concentration of the linear poly β‐CD to meet the treating requirement, and a multistage drug controlled‐release mechanism was proposed. In conclusion, the VCZ‐loaded in situ injectable hydrogel should be offered as a promising strategy for intraocular drug delivery in vitreous cavity for the treatment of fungal endophthalmitis. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1909–1916, 2019.

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“…Thanks to the emerging “click” chemistry, chemically cross‐linked injectable hydrogels with relatively high mechanical strength have made significant progress. “Click” reactions, such as metal‐catalyzed/free azide–alkyne cycloaddition, thiol‐ene/yne addition, epoxy–amine reaction, Diels–Alder reaction, Schiff base reaction, and hydrazone reaction, have provided great advantages, including ambient reaction conditions and high efficiency to in situ form hydrogels. Multi‐arm PEG (MA‐PEG) is a good precursor for in situ forming chemically cross‐linked PEG hydrogels after chemical modification of the end groups.…”

Section: Introductionmentioning

confidence: 99%

Injectable poly(ethylene glycol) hydrogels for sustained doxorubicin release

Gao

Sun

Wang

et al. 2016

Polymers for Advanced Techs

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Water‐soluble poly(ethylene glycol) derivatives with multiple “clickable” mercapto groups or double bonds were facilely synthesized in a large scale by direct polycondensation of oligo(ethylene glycol) diol with mercaptosuccinic acid or maleic acid catalyzed by scandium trifluoromethanesulfonate under mild conditions. Injectable hydrogels containing doxorubicin hydrochloride (DOX · HCl) could be rapidly formed using these poly(ethylene glycol) derivatives as precursors via in situ thiol‐ene “click” reaction under physiological conditions without light, initiator, or metal catalyst. DOX · HCl could be sustained released from the hydrogels as a result of the hindrance of the three dimensional hydrogel network on the drug molecules, which makes this kind of DOX‐loaded hydrogels a promising candidate for localized tumor chemotherapy. Copyright © 2016 John Wiley & Sons, Ltd.

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An injectable drug-loaded hydrogel based on a supramolecular polymeric prodrug

Cited by 81 publications

References 42 publications

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

Injectable Schiff base polysaccharide hydrogels for intraocular drug loading and release

Injectable poly(ethylene glycol) hydrogels for sustained doxorubicin release

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