An injectable supramolecular self-healing bio-hydrogel with high stretchability, extensibility and ductility, and a high swelling ratio

Zhu, Shukai; Wang, Jianxin; Yan, Haoran; Wang, Yingying; Zhao, Yuancong; Feng, Bo; Duan, Ke; Weng, Jie

doi:10.1039/c7tb01183k

Cited by 41 publications

(32 citation statements)

References 48 publications

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“…[4] Among them, in situ formed injectable hydrogel system has attracted much attention for wound healing application in recent years. [5][6][7] The injectable hydrogel can be easily applied on any irregular shape during hydrogel formation without using the complex mould, [8][9][10] and possess the advantages of easy administration, efficient cell encapsulation, minimal invasion, and enhanced patient compliance, [11] making them attractive for various biomedical applications. The components of injectable hydrogels range from natural (e.g.…”

Section: Introductionmentioning

confidence: 99%

A hybrid injectable hydrogel from hyperbranched PEG macromer as a stem cell delivery and retention platform for diabetic wound healing

et al. 2018

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Diabetic wounds, which are a severe type of diabetes, have become one of the most serious clinical problems. There is a great promise in the delivery of adipose stem cells into wound sites using injectable hydrogels that can improve diabetic wound healing. Due to the biocompatibility of poly(ethylene glycol) diacrylate (PEGDA), we developed an in situ RAFT polymerization approach using anti-alcoholic drug-Disulfiram (DS) as a RAFT agent precursor to achieve hyperbranched PEGDA (HP-PEG). HP-PEG can form an injectable hydrogel by crosslinking with thiolated hyaluronic acid (HA-SH). ADSCs can maintain their regenerative ability and be delivered into the wound sites. Hence, diabetic wound healing process was remarkably promoted, including inhibition of inflammation, enhanced angiogenesis and re-epithelialization. Taken together, the ADSCs-seeded injectable hydrogel may be a promising candidate for diabetic wound treatment.

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Section: Introductionmentioning

confidence: 99%

A hybrid injectable hydrogel from hyperbranched PEG macromer as a stem cell delivery and retention platform for diabetic wound healing

et al. 2018

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“…Self-healing hydrogels have received increasing attentions in biomedical applications, such as wound healing (Gaharwar et al, 2014 ; Han et al, 2016 ; Zhao et al, 2017 ; Zhu, S. K. et al, 2017 ; Li et al, 2018 ; Liu, B. et al, 2018 ), drug delivery (Huebsch et al, 2014 ; Liu et al, 2016 ; Wang et al, 2016 ; Xing et al, 2016 ; Wang J. Y. et al, 2017 ; Xia et al, 2017 ; Yavvari et al, 2017 ; Zhu, C. et al, 2017 ; Hong et al, 2018 ), tissue engineering (Dankers et al, 2012 ; Bastings et al, 2014 ; Gaffey et al, 2015 ; Rodell et al, 2015a , b ; Loebel et al, 2017 ), surface coating (Canadell et al, 2011 ; Yoon et al, 2011 ; Yang et al, 2015 ), 3D printing (Highley et al, 2015 ; Darabi et al, 2017 ; Loebel et al, 2017 ; Wang et al, 2018 ), and soft robot (Shi et al, 2015 ; Darabi et al, 2017 ; Han et al, 2017 ; Liu, B. et al, 2018 ; Liu et al, 2018 ). In these cases, dibenzaldehyde-based, UPy-based, catechol-based, and host–guest-based self-healing hydrogels are highlighted due to many evaluations of in vivo experiments.…”

Section: Biomedical Applications Of Self-healing Hydrogelsmentioning

confidence: 99%

Synthesis and Biomedical Applications of Self-healing Hydrogels

2018

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Hydrogels, which are crosslinked polymer networks with high water contents and rheological solid-like properties, are attractive materials for biomedical applications. Self-healing hydrogels are particularly interesting because of their abilities to repair the structural damages and recover the original functions, similar to the healing of organism tissues. In addition, self-healing hydrogels with shear-thinning properties can be potentially used as the vehicles for drug/cell delivery or the bioinks for 3D printing by reversible sol-gel transitions. Therefore, self-healing hydrogels as biomedical materials have received a rapidly growing attention in recent years. In this paper, synthesis methods and repair mechanisms of self-healing hydrogels are reviewed. The biomedical applications of self-healing hydrogels are also described, with a focus on the potential therapeutic applications verified through in vivo experiments. The trends indicate that self-healing hydrogels with automatically reversible crosslinks may be further designed and developed for more advanced biomedical applications in the future.

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“…Self-healing soft materials find applications in engineering and bio-medical fields. The major uses of self-healing materials so far are in surface coating (Canadell et al, 2011;Yoon et al, 2012;Yang et al, 2015a), drug delivery (Huebsch et al, 2014;Liu et al, 2016;Wang et al, 2016Wang et al, , 2017aXing et al, 2016;Xia et al, 2017;Yavvari et al, 2017;Hong et al, 2018), tissue engineering (Dankers et al, 2012;Bastings et al, 2014;Gaffey et al, 2015;Rodell et al, 2015;Loebel et al, 2017), wound healing (Gaharwar et al, 2014;Han et al, 2016;Zhao et al, 2017b;Zhu et al, 2017;Li et al, 2018c), and soft robotics (Shi et al, 2015;Darabi et al, 2017;Han et al, 2017b;Liu et al, 2018b). Herein, some applications of soft self-healing nanocomposites in biomedical fields including drug delivery tissue adhesive, as well as in industrial fields including actuators, sensors, and coatings are gathered ( Table 5).…”

Section: Applicationsmentioning

confidence: 99%

Soft Self-Healing Nanocomposites

et al. 2019

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This review article provides an overview of the research and applications of soft self-healing polymers and their nanocomposites. A number of concepts based on physical and chemical interactions have been explored to create dynamic and reversible gel and elastomer networks, each strategy presenting its own advantages and drawbacks. Physical interactions include supramolecular interactions, ionic bonding, hydrophobic interactions, and multiple intermolecular interactions. Such networks do not require external stimulus and are capable of multiple self-healing cycles. They are generally characterized by a rapid but limited healing efficiency. The addition of nanofillers enhances the mechanical strength of the soft networks as in conventional gels and elastomers, and do not compromise the network healing dynamics. In certain cases, nanofillers moreover trigger the healing process through e.g., multi-complexation processes between each component. Chemical interactions include Diels-Alder reactions and disulphide, imine, boronate ester, or acylhydrazones bonding, and are usually triggered with an external stimulus. The resulting healing is efficient, leading to good mechanical properties, but is generally slow at ambient temperatures, and dynamic chemical interactions are only reversible at higher temperatures. Conductive nanofillers were reported to speed up the healing process in such systems owing to their energy absorption properties. The challenges with nanofillers remain their functionalization and dispersion within the self-healing formulations. Soft self-healing gels and nanocomposites find applications in engineering such as coatings, sensors, actuators and soft robotics, and in the bio-medical field, including drug delivery, adhesives, tissue engineering and wound healing.

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An injectable supramolecular self-healing bio-hydrogel with high stretchability, extensibility and ductility, and a high swelling ratio

Abstract: Reversible networks are a key factor for designing self-healing hydrogels with high stretching properties.

Cited by 41 publications

References 48 publications

A hybrid injectable hydrogel from hyperbranched PEG macromer as a stem cell delivery and retention platform for diabetic wound healing

A hybrid injectable hydrogel from hyperbranched PEG macromer as a stem cell delivery and retention platform for diabetic wound healing

Synthesis and Biomedical Applications of Self-healing Hydrogels

Soft Self-Healing Nanocomposites

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