An inner confidence

Holley, Chris; Holley,; Mayne, Liz

doi:10.7748/ns.22.52.64.s36

Cited by 3 publications

(3 citation statements)

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“…arginine, lysine) that stabilizes their structures. [71][72][73][74] For the PM peptide, all the three Glu mutations have Arg residues nearby. Specifically, Glu23, positioned at the hinge random coil joining the two helices, can control the relative motion of the two helical arms by interacting with the nearby Arg12 and Arg29, thereby modulating conformational rigidity.…”

Section: Variation Of Salt Concentrationmentioning

confidence: 99%

Phosphorylation Induces Conformational Rigidity at the C-Terminal Domain of AMPA Receptors

et al. 2018

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The intracellular C-terminal domain (CTD) of AMPA (α-amino-3-hydroxy-5-methyl-4isoxazolepropionic acid) receptor undergoes phosphorylation at specific locations during longterm potentiation (LTP). This modification enhances conductance through the AMPA receptor ion channel and thus potentially plays a crucial role in modulating receptor trafficking and signaling. However, because the CTD structure is largely unresolved, it is difficult to establish if phosphorylation induces conformational changes that might play a role in enhancing channel conductance. Herein, we utilize single molecule Fӧrster Resonance Energy Transfer (smFRET) spectroscopy to probe the conformational changes of a section of the AMPA receptor CTD, under the conditions of point-mutated phosphomimicry. Multiple analysis algorithms fail to identify stable conformational states within the smFRET distributions, consistent with a lack of welldefined secondary structure. Instead, our results show that phosphomimicry induces conformational rigidity to the CTD and such rigidity is electrostatically tunable.

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Section: Variation Of Salt Concentrationmentioning

confidence: 99%

Phosphorylation Induces Conformational Rigidity at the C-Terminal Domain of AMPA Receptors

et al. 2018

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“…W prasie amerykańskiej odwoływano się do opinii chińskich intelektualistów, którzy widzieli trzy przyczyny zainteresowania Chińczyków wojną w Zatoce: "znudzenie codziennym życiem, niezadowolenie z chińskiego dyktatorskiego przywództwa i szacunek dla amerykańskiej wolności politycznej oraz technicznego wyrafinowania". Wiele postronnych osób na chińskiej ulicy sympatyzując ze Stanami Zjednoczonymi opowiadało się nawet za chińskim udziałem w interwencji przeciwko Irakowi 51 . Dziennikarze amerykańscy powoływali się też na liczne listy Chińczyków do ambasady amerykańskiej z wyrazami poparcia oraz przesyłkami pieniężnymi mającymi wesprzeć Amerykanów 52 .…”

Section: Tabela 1 Porównanie Tonażu Bomb Zrzuconych Przez Lotnictwo unclassified

Chiny (ChRL) i ZSRR wobec wojny w Zatoce Perskiej (1991 r.)

Dmochowski¹

2012

npw

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“…26 31 He goes on to assert that "Clausewitz wrote after the Industrial Revolution was well under way, but his writings show an utter lack of appreciation of the implications for the development of weapons in the new mechanization." 32 It can be argued that he is correct, for in World War II, we finally created the ultimate weapon. The atomic bomb promised massive destruction while enabling, especially when combined with intercontinental ballistic missiles, huge standoff ranges.…”

Section: War Some Definitionsmentioning

confidence: 99%

Functional Geonic Analysis of Breast Cancer Cell Tumorigenicity Using a Noval Gene Silencing Resource

Conklin¹

2007

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Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. Technology offers the promise of easy victory. Humans are perceived as messy and difficult to control, while technology is perceived as clean and easy to control. This paper explores both human and technology impacts on warfare in the past, present, and future. The challenge for military strategists is to understand the correct emphasis to put on technology while pursuing a human outcome.v Chapter 1

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An inner confidence

Cited by 3 publications

References 0 publications

Phosphorylation Induces Conformational Rigidity at the C-Terminal Domain of AMPA Receptors

Phosphorylation Induces Conformational Rigidity at the C-Terminal Domain of AMPA Receptors

Chiny (ChRL) i ZSRR wobec wojny w Zatoce Perskiej (1991 r.)

Functional Geonic Analysis of Breast Cancer Cell Tumorigenicity Using a Noval Gene Silencing Resource

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