An innovative approach for assessing coronary artery lesions: Fusion of wrist pulse and photoplethysmography using a multi-sensor pulse diagnostic device

Ma, Xiaotian; Guo, Rui; Zhang, Chunke; Yan, Jianjun; Zhu, Guangyao; Wu, Wenjie; Yan, Haixia; Hong, Leixin

doi:10.1016/j.heliyon.2024.e28652

Cited by 3 publications

References 19 publications

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Achieving low radiation dose and contrast agents dose in coronary CT angiography at 60-kVp ultra-low tube voltage

He,

Huang,

et al. 2024

Preprint

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Objectives To explore the feasibility of a one-beat protocol and ultra-low tube voltage of 60 kVp in coronary CT angiography (CCTA). Methods This prospective study enrolled 107 patients (body mass index ≤ 26 kg/m2) undergoing CCTA examinations. Specificially, the conventional group (n = 52) underwent 100 kVp scanning with 45 ml iodine contrast agent and 4 ml/s injection rate, and the low-dose group (n = 55) underwent 60 kVp scanning with 28 ml iodine contrast agent and 2.5 ml/s injection rate. The CT value, signal-noise-ratio (SNR), contrast-noise-ratio (CNR) and subjective image quality score of two groups in aorta (AO), right coronary artery (RCA), left anterior descending (LAD) and left circumflex (LCX) are analyzed in this study. Three types of radiation doses [i.e., volume CT dose index (CTDIvol), dose length product (DLP), effective dose (ED)] of two groups are also compared. Results The quantitative results indicated that the low-dose group achieved higher CT values, SNR and CNR results of the AO than the conventional group(P values < 0.001). Both groups had similar CT values, SNR and CNR results in RCA, LAD, and LCX (P values > 0.05). A good agreement is noted with respect to subjective image quality scores in both groups, while the Cohen's kappa value is 0.815 in the low-dose group and 0.825 in conventional group, respectively. In addition, the radiation dose of the low-dose group are significantly lower than the conventional group in terms of CTDIvol, DLP and ED values, and the contrast dose in the low-dose group is also significantly reduced compared to the conventional group(P values < 0.001). Conclusions One-beat protocol with a ultra-low tube voltage of 60 kVp could provide improved coronary image quality, reduced radiation dose and reduced iodine contrast dose.

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Achieving low radiation dose and contrast agents dose in coronary CT angiography at 60-kVp ultra-low tube voltage

He,

Huang,

et al. 2024

Preprint

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PPG and Bioimpedance-Based Wearable Applications in Heart Rate Monitoring—A Comprehensive Review

Lapsa,

Janeliukstis,

Metshein

et al. 2024

Applied Sciences

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The monitoring of hemodynamic parameters, such as heart rate and blood pressure, provides valuable indications of overall cardiovascular health. It is preferable that such monitoring is non-invasive and in real time via an affordable, compact and small-scale device for maximum convenience. Numerous literature sources have exploited derivations of these parameters from photoplethysmogram (PPG) and electrical bioimpedance (EBI) signal measurements through the use of calculation algorithms of varying complexity. Compared to electrocardiogram (ECG), these measurement techniques have a merit of well-established practices of designing a wearable device that could conveniently be put on a wrist. The current paper provides a comprehensive review on the use of PPG and EBI measurement techniques in the context of hemodynamic parameter monitoring using a wearable device. A special emphasis is placed on the most basic hemodynamic parameter—heart rate—describing different algorithms of heart rate detection and monitoring. The last section provides an overview of commercially available and in-home wearable device technologies based on PPG and EBI measurements, their design challenges, and future prospects.

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Construction of Immune-Related circRNA-miRNA-mRNA Network and Identification of circRNAs as Biomarkers in Coronary Atherosclerotic Heart Disease

Qian,

Chen,

Chai

et al. 2024

CIMB

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Circular RNAs (circRNAs) play crucial roles in the immune and inflammatory responses of many diseases by acting as competing endogenous RNAs (ceRNAs). However, the role of circRNAs as ceRNAs in the immune and inflammatory processes of coronary atherosclerosis heart disease (CHD) remains unclear. This study aimed to identify and validate the potential immune-related circRNAs as biomarkers for CHD. Firstly, we constructed a ceRNA regulatory network including 14 circRNAs, 24 miRNAs, and 15 genes through bioinformatics analysis. Four hub genes were identified and five candidate immune-related circRNAs were screened. Subsequently, the expression levels of these candidate circRNAs were detected by qRT-PCR. Notably, hsa_circRNA_101069 and hsa_circRNA_406053 showed significant up-regulation in CHD patients (p < 0.001). The value of these circRNAs as biomarkers for CHD was evaluated by the area under the ROC curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI) indexes. Adding circRNAs to a traditional CHD model significantly enhanced classification performance, with an IDI of 0.058 and an NRI of 0.280 for hsa_circRNA_101069 and an IDI of 0.051 and an NRI of 0.480 for hsa_circRNA_406053. Furthermore, hsa_circRNA_101069 was up-regulated in ox-LDL-induced THP-1 macrophages, and silencing hsa_circRNA_101069 significantly inhibited the apoptosis rates and the inflammatory cytokines levels. This study constructed an immune-related circRNA-miRNA-mRNA network and identified two circRNAs as biomarkers for CHD, with hsa_circRNA_101069 potentially contributing to the pathological basis of CHD.

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An innovative approach for assessing coronary artery lesions: Fusion of wrist pulse and photoplethysmography using a multi-sensor pulse diagnostic device

Cited by 3 publications

References 19 publications

Achieving low radiation dose and contrast agents dose in coronary CT angiography at 60-kVp ultra-low tube voltage

Achieving low radiation dose and contrast agents dose in coronary CT angiography at 60-kVp ultra-low tube voltage

PPG and Bioimpedance-Based Wearable Applications in Heart Rate Monitoring—A Comprehensive Review

Construction of Immune-Related circRNA-miRNA-mRNA Network and Identification of circRNAs as Biomarkers in Coronary Atherosclerotic Heart Disease

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