An Innovative Bioceramic Bone Graft with Platelet-Rich Plasma for Rapid Bone Healing and Regeneration in a Rabbit Model

Syam, Syamsiah; Chang, Chun Wei; Lan, Wen Chien; Ou, Keng Liang; Huang, Bai Hung; Lin, Yu Yeong; Saito, Takashi; Tsai, Hsin Yu; Chuo, Yen Chun; Yang, Tzu Sen; Liu, Chung Ming; Hou, Ping Jen

doi:10.3390/app11115271

Cited by 7 publications

(5 citation statements)

References 54 publications

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“…Therefore, in the radiographic appearance, there was no wound closure in all treatments in the second week. In the biological process of bone repair, the final phase, namely the remodeling phase, begins with the formation of granulation tissue [42]. Histological analysis in this study showed that the bone healing process had been seen in the second week.…”

Section: Discussionmentioning

confidence: 58%

Suckermouth catfish bone extract as bone graft raw material for bone-healing promotes bone growth in bone loss

DJAMALUDDIN,

HAMRUN,

NATSIR

et al. 2023

Braz. Dent. Sci.

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Objective: This study aimed to evaluate the properties of suckermouth catfish bone extract, which allows it to be adopted as a raw material for bone graft following its graft in an artificial defect of a rat model. Material and Methods: Hydroxyapatite (HA) from suckermouth catfish bone extract was characterized using Fourier-transform infrared spectroscopy (FTIR), and its toxicity was evaluated by Brine Shrimp Lethality Test (BSLT). This material was grafted on artificial defects in rats' femoral bones, which were observed immunologically by Enzyme-linked immunosorbent assay (ELISA) after one week and four weeks, and radiographically in the second week, and histologically in the second and fourth weeks. Results: FTIR shows that this material consists of phosphate, hydroxyl, and carbonate groups, while the BSLT results show that this material is not toxic. Observations by ELISA showed an increase in the expression of Tumor necrosis factor alpha (TNF-α) in defects with HA in the fourth week. Radiographically the defect did not show closure in the second week. In contrast, histological analysis showed a better bone healing process in the defect, which was applied with the HA of the suckermouth catfish bone. Conclusion:The HA extracted from the suckermouth catfish bone has beneficial properties as an alternative to bone graft raw material and, more investigated needed to support this biomaterial to be used in the treatment of bone loss.

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Section: Discussionmentioning

confidence: 58%

Suckermouth catfish bone extract as bone graft raw material for bone-healing promotes bone growth in bone loss

DJAMALUDDIN,

HAMRUN,

NATSIR

et al. 2023

Braz. Dent. Sci.

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“…The α-CSH, a substance with remarkable characteristics such as high self-setting strength, excellent osteoinductive properties, biocompatibility, and angiogenesis capabilities, has emerged as a popular alternative to traditional bone grafts [ 29 - 31 ]. Previous in vitro and in vivo studies conducted by our team have demonstrated the ability of α-CSH to promote angiogenesis and enhance osteogenesis [ 14 , 17 , 29 ]. Given the strategic development of α-CSH as a potential biomaterial for bone regeneration, it holds promise as a unique biocomposite bone graft material to be investigated in this study [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Feasibility and Preliminary Efficacy of α–Calcium Sulfate Hemihydrate in Socket Preservation: Protocol for a Pilot Randomized Controlled Trial

Ruslin,

Hamrun,

Tajrin

et al. 2024

JMIR Res Protoc

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Background Tooth extraction procedures often lead to bone resorption, which can have adverse effects on the dimensions of the alveolar ridge. Research has shown that socket preservation techniques using bone graft substitutes can effectively minimize early bone loss in such cases. α–calcium sulfate hemihydrate (α-CSH) has garnered significant attention as a potential bone graft material due to its favorable properties, including osteoconductivity, angiogenic potential, and biocompatibility. Considering these facts, we developed a preliminary protocol for applying α-CSH in addressing alveolar bone loss following tooth extraction. Objective This research’s general objective is to evaluate the feasibility and initial effectiveness of α-CSH as bone-inducing graft material for socket preservation after tooth extraction. Methods This preliminary clinical trial will involve 30 fresh extraction sockets from individuals aged 18-35 years. The participants will be divided into 2 groups: one group will receive α-CSH graft material after tooth extraction for socket preservation, while the other group will not receive any graft material. Throughout the study, the participants will be closely monitored for safety measures, which will include clinical examinations, radiographic imaging, and blood tests. Radiographic imaging will be used extensively to assist the progress of bone formation. Results The study commenced enrollment in August 2022 and is scheduled to conclude post assessments and analyses by the end of 2023. The results of the study are anticipated to be accessible in late 2024. Conclusions This clinical study represents the initial investigation in humans to assess the feasibility and efficacy of α-CSH in alveolar bone regeneration. We hypothesize that the inclusion of α-CSH can greatly expedite the process of bone formation within fresh sockets, resulting in a swift restoration of bone height without the disadvantages associated with harvesting autogenous bone graft. Trial Registration Indonesia Registry Center INA-D02FAHP; https://tinyurl.com/2jnf6n3s International Registered Report Identifier (IRRID) DERR1-10.2196/49922

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“…In this study, the mRNA expression and the protein expression in P3 were higher than that in P0 at both time points, confirming that the addition of PRP had a clear osteogenic-inducing activity. Several past studies showed that the addition of PRP in human clinical trials increases BMD in maxillary sinus defects, reduces defect volume, and increases granulation, osteoblast, and angiogenesis [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…CSH bone graft combined with autologous platelet gel was more effective than CSH alone in treating maxillary sinus defect. CSH bone graft with PRP showed an increase in bone mineral density (BMD), granulation tissue, and angiogenesis at two weeks after implantation [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Platelet-Rich Plasma Addition on the Chemical Properties and Biological Activity of Calcium Sulfate Hemihydrate Bone Cement

et al. 2023

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Currently, platelet-rich plasma (PRP) is an attractive additive for bone repair materials. PRP could enhance the osteoconductive and osteoinductive of bone cement, as well as modulate the degradation rate of calcium sulfate hemihydrate (CSH). The focus of this study was to investigate the effect of different PRP ratios (P1: 20 vol%, P2: 40 vol%, and P3: 60 vol%) on the chemical properties and biological activity of bone cement. The injectability and compressive strength of the experimental group were significantly higher than those of the control. On the other hand, the addition of PRP decreased the crystal size of CSH and prolonged the degradation time. More importantly, the cell proliferation of L929 and MC3T3-E1 cells was promoted. Furthermore, qRT-PCR, alizarin red staining, and western blot analyses showed that the expressions of osteocalcin (OCN) and Runt-related transcription factor 2 (Runx2) genes and β-catenin protein were up-regulated, and mineralization of extracellular matrix was enhanced. Overall, this study provided insight into how to improve the biological activity of bone cement through PRP incorporation.

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An Innovative Bioceramic Bone Graft with Platelet-Rich Plasma for Rapid Bone Healing and Regeneration in a Rabbit Model

Cited by 7 publications

References 54 publications

Suckermouth catfish bone extract as bone graft raw material for bone-healing promotes bone growth in bone loss

Suckermouth catfish bone extract as bone graft raw material for bone-healing promotes bone growth in bone loss

Feasibility and Preliminary Efficacy of α–Calcium Sulfate Hemihydrate in Socket Preservation: Protocol for a Pilot Randomized Controlled Trial

Effect of Platelet-Rich Plasma Addition on the Chemical Properties and Biological Activity of Calcium Sulfate Hemihydrate Bone Cement

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