An in-situ combustion method is an effective method to enhance oil recovery with high economic recovery rate, low risk, fast promotion and application speed. Currently, in-situ combustion technique is regarded as the last feasible thermal recovery technology to replace steam injection in the exploitation of bitumen sands and heavy oil reservoirs. However, the oil-discharging mechanism during the in-situ combustion process is still not clearly understood. In this paper, the in-situ combustion process has been numerically simulated based on the Du 66 block. The effect of production parameters (huff and puff rounds, air injection speed, and air injection temperature) and geological parameters (bottom water thickness, stratigraphic layering, permeability ratio, and formation thickness) on the heavy oil recovery have been comprehensively analyzed. Results show that the flooding efficiency is positively correlated with the thickness of the bottom water, and negatively correlated with the formation heterogeneity. There exist optimum values for the oil layer thickness, huff and puff rounds, and air injection speed. And the effect of air injection temperature is not significant. The results of this paper can contribute to the understanding of mechanisms during in-situ combustion and the better production design for heavy oil reservoirs.