An innovative study on the “on–off–on” detection of sulfur ions based on a TSPP–riboflavin fluorescent probe

Abstract

In this paper, 5,10,15,20-(4-sulphonatophenyl) porphyrin (TSPP) was synthesized by a facile route and used as a fluorescent probe to construct a sensor system based on the high water solubility and high quantum yield.

Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species

“…Using a related strategy but moving to the NIR, Liang, Li, and Li reported the lipophilic and cell membrane-targeting probe 791 (CMCu-H 2 S), which reacts with H 2 S to generate a fluorescent response at 790 nm. 801 This probe was used to image H 2 S near the membrane of live HepG2 cells using both exogenous and Cys-derived H 2 S and also used to investigate H 2 S levels during NFS1 inhibition or knockdown. Expanding to Ru-based luminescent systems, Ye and Yuan reported the Cu 2+ -cyclen Ru(bpy) 2 motif 792, which provided a fluorescence turn-on at 605 nm in response to H 2 S. 802 This probe showed good selectivity over different anion, amino acid, and thiol competing analytes.…”

“…This probe showed good selectivity over competing analytes and was used to image exogenous and Cys-derived H 2 S in HeLa and EMT6 cells. Using a related strategy but moving to the NIR, Liang, Li, and Li reported the lipophilic and cell membrane-targeting probe 791 (CMCu-H 2 S), which reacts with H 2 S to generate a fluorescent response at 790 nm . This probe was used to image H 2 S near the membrane of live HepG2 cells using both exogenous and Cys-derived H 2 S and also used to investigate H 2 S levels during NFS1 inhibition or knockdown.…”