An Insight into Nanosomes: Potential Nanopharmaceutical Delivery System

Bal, Trishna; Sandeep, Garg; Rajora, Aditya Dev; Sharma, S.; Hars, Harshita

doi:10.1002/9781119711698.ch12

Cited by 1 publication

(1 citation statement)

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“…They described that, lots of innovations are expected in the future for nanotechnology in biomedical sciences for various applications such as biosensors, drug delivery and gene delivery compounds, as well as molecular imaging. Trishna et al [13] introduced the concept of nanosomes as promising drug delivery sample. They reported the import/export of the nanosomes takes place via various cycles of endocytosis/exocytosis to a target site which depends on various parameters such as size, shape, and ligands existence.…”

Section: Introductionmentioning

confidence: 99%

Computational Study of Diol Camptothecin Drug Delivery Process Using MPEG-1 based Nanosome Structure: Molecular Dynamics Approach

Bahreini

Ghaffari

2023

Preprint

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Nanosomes are nano-scale vesicles of spherical shape that can be created from different self-assembled nanosize components. In current research, we introduced Macrophage-Expressed Gene (MPEG-1) protein based nanosome performance in diol camptothecin (CPT(OH)2) drug delivery process in aqueous environment for the first time. The molecular dynamics (MD) method used for this purpose. Technically, our simulations done in two phases. In the first phase, defined samples equilibrated at initial condition (T0 = 300 K and P0 = 1 bar). Then, drug delivery performance of equilibrated samples reported by various parameter calculations such as drug release ratio, root mean square displacement, charge density, and Zeta function. Computational outputs predicted atomic stability of samples in defined condition. This performance conducted from kinetic and potential energy convergence in equilibrium phase. Also, drug delivery process detected after 0.12 ns in aqueous environment. Numerically, drug delivery ratio reached to 64% at standard condition. From this output, we concluded MPEG-1 based nanosome can be used in actual cases for drug delivery process in clinical applications.

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Section: Introductionmentioning

confidence: 99%